Biosynthesis of bioactive natural products from Basidiomycota

Hsiao-Ching Lin, Ranuka T. Hewage, Yuan-Chun Lu, Yit-Heng Chooi

Research output: Contribution to journalReview articlepeer-review

32 Citations (Scopus)


The Basidiomycota, also called club fungi, comprise a diverse group of fungi. Basidiomycota are strongly related to ecosystem functioning along with human life. These fungi display a wide range of bioactivities, and some are known to produce of deadly toxins or hallucinogens. Some Basidiomycota have be used as medicinal mushrooms for thousands of years. Recently, the biosyntheses of several classes of natural products from Basidiomycota have been reported. Here, we review recent studies on the biosynthetic pathways and enzymes of bioactive natural products from Basidiomycota fungi, with a focus on terpenoids, alkaloids, ribosomally synthesized and post- translationally modified peptides (RiPPs), and polyketides.

Original languageEnglish
Pages (from-to)1027-1036
Number of pages10
JournalOrganic & Biomolecular Chemistry
Issue number5
Publication statusPublished - 7 Feb 2019


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