Biomaterial templates for the culture and transplantation of retinal pigment epithelial cells: A critical review

A. M.A. Shadforth, Traian V. Chirila, Damien G. Harkin, A. S.L. Kwan, F. K. Chen

Research output: Chapter in Book/Conference paperChapter

1 Citation (Scopus)

Abstract

The idea of retinal cell transplantation as a potential treatment for age-related retinal degeneration, a leading cause of blindness in the Western world, has been around for a number of decades. To date, however, it has not been entirely successful; one of the main reasons for this is the lack of an ideal substratum for the retinal cells, specifically for the growth of retinal pigment epithelial cells prior to transplantation. This chapter reviews the reasoning behind this potential treatment, the development of animal transplantation models for human trials, the prerequisites of an ideal substratum, the past and current research on substratum materials, and the potential for future developments in this area.

Original languageEnglish
Title of host publicationBiomaterials and Regenerative Medicine in Ophthalmology
EditorsT V Chirilia, D Harkin
PublisherElsevier
Pages263-289
Number of pages27
Volume112
Edition2nd
ISBN (Electronic)9780081001844
ISBN (Print)9780081001479
DOIs
Publication statusPublished - 21 Apr 2016

Publication series

NameWoodhead Publishing Series in Biomaterials

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