Projects per year
Abstract
I aimed to tackle a clinical challenge of post-surgery cancer recurrence by developing a surgically
optimised hydrogel that could be applied in the wound after surgery to release immunotherapy and kill remaining cancer cells. I demonstrated that the immunotherapy hydrogel prevents cancer
recurrence in multiple preclinical models of surgery. I showed the safety and feasibility of the
immunotherapy hydrogel in a real-world oncological setting in a canine veterinary trial in pet dogs with sarcoma undergoing surgery. These data demonstrate a surgically optimised intraoperative immunotherapy gel that can be applied in the context of surgery to prevent cancer recurrence.
optimised hydrogel that could be applied in the wound after surgery to release immunotherapy and kill remaining cancer cells. I demonstrated that the immunotherapy hydrogel prevents cancer
recurrence in multiple preclinical models of surgery. I showed the safety and feasibility of the
immunotherapy hydrogel in a real-world oncological setting in a canine veterinary trial in pet dogs with sarcoma undergoing surgery. These data demonstrate a surgically optimised intraoperative immunotherapy gel that can be applied in the context of surgery to prevent cancer recurrence.
Original language | English |
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Qualification | Doctor of Philosophy |
Awarding Institution |
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Supervisors/Advisors |
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Thesis sponsors | |
Award date | 29 May 2023 |
DOIs | |
Publication status | Unpublished - 2023 |
Embargo information
- Embargoed from 29/05/2023 to 17/05/2024. Made publicly available on 17/05/2024.
Fingerprint
Dive into the research topics of 'Biomaterial-assisted delivery of immunotherapy: a novel approach to prevent cancer recurrence'. Together they form a unique fingerprint.Projects
- 1 Finished
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Interoperative immunotherapy to prevent relapse in soft tissue sarcoma
Lesterhuis, W. (Investigator 01), Swaminatha Iyer, I. (Investigator 02) & Wyatt, K. (Investigator 03)
1/01/20 → 31/03/22
Project: Research
Research output
- 1 Article
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A mouse model of incompletely resected soft tissue sarcoma for testing (Neo)adjuvant therapies
Rwandamuriye, F. X., Weston, B. J., Johns, T. G., Lesterhuis, W. J. & Zemek, R. M., Jul 2020, In: Journal of Visualized Experiments. 161, p. 1-11 11 p., e60882.Research output: Contribution to journal › Article › peer-review
7 Citations (Scopus)