Biomaterial-assisted delivery of immunotherapy: a novel approach to prevent cancer recurrence

Francois Rwandamuriye

doi:10.26182/89kg-wx08

Biomaterial-assisted delivery of immunotherapy: a novel approach to prevent cancer recurrence

Francois Rwandamuriye

School of Biomedical Sciences

Research output: Thesis › Doctoral Thesis

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Abstract

I aimed to tackle a clinical challenge of post-surgery cancer recurrence by developing a surgically
optimised hydrogel that could be applied in the wound after surgery to release immunotherapy and kill remaining cancer cells. I demonstrated that the immunotherapy hydrogel prevents cancer
recurrence in multiple preclinical models of surgery. I showed the safety and feasibility of the
immunotherapy hydrogel in a real-world oncological setting in a canine veterinary trial in pet dogs with sarcoma undergoing surgery. These data demonstrate a surgically optimised intraoperative immunotherapy gel that can be applied in the context of surgery to prevent cancer recurrence.

Original language	English
Qualification	Doctor of Philosophy
Awarding Institution	The University of Western Australia
Supervisors/Advisors	Swaminatha Iyer, Iyer, Supervisor Lesterhuis, Willem, Supervisor Wylie, Ben, Supervisor Zemek, Rachael, Supervisor
Thesis sponsors	Australian Government Research Training Program
Award date	29 May 2023
DOIs	https://doi.org/10.26182/89kg-wx08
Publication status	Unpublished - 2023

Embargo information

Embargoed from 29/05/2023 to 17/05/2024. Made publicly available on 17/05/2024.

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.26182/89kg-wx08

THESIS - DOCTOR OF PHILOSOPHY - RWANDAMURIYE Francois - 2023
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1 Finished

Interoperative immunotherapy to prevent relapse in soft tissue sarcoma
Lesterhuis, W. (Investigator 01), Swaminatha Iyer, I. (Investigator 02) & Wyatt, K. (Investigator 03)
Cancer Australia
1/01/20 → 31/03/22
Project: Research

1 Article

A mouse model of incompletely resected soft tissue sarcoma for testing (Neo)adjuvant therapies
Rwandamuriye, F. X., Weston, B. J., Johns, T. G., Lesterhuis, W. J. & Zemek, R. M., Jul 2020, In: Journal of Visualized Experiments. 161, p. 1-11 11 p., e60882.
Research output: Contribution to journal › Article › peer-review
7 Citations (Scopus)

Cite this

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title = "Biomaterial-assisted delivery of immunotherapy: a novel approach to prevent cancer recurrence",

abstract = "I aimed to tackle a clinical challenge of post-surgery cancer recurrence by developing a surgicallyoptimised hydrogel that could be applied in the wound after surgery to release immunotherapy and kill remaining cancer cells. I demonstrated that the immunotherapy hydrogel prevents cancerrecurrence in multiple preclinical models of surgery. I showed the safety and feasibility of theimmunotherapy hydrogel in a real-world oncological setting in a canine veterinary trial in pet dogs with sarcoma undergoing surgery. These data demonstrate a surgically optimised intraoperative immunotherapy gel that can be applied in the context of surgery to prevent cancer recurrence.",

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AB - I aimed to tackle a clinical challenge of post-surgery cancer recurrence by developing a surgicallyoptimised hydrogel that could be applied in the wound after surgery to release immunotherapy and kill remaining cancer cells. I demonstrated that the immunotherapy hydrogel prevents cancerrecurrence in multiple preclinical models of surgery. I showed the safety and feasibility of theimmunotherapy hydrogel in a real-world oncological setting in a canine veterinary trial in pet dogs with sarcoma undergoing surgery. These data demonstrate a surgically optimised intraoperative immunotherapy gel that can be applied in the context of surgery to prevent cancer recurrence.

KW - cancer

KW - surgery

KW - recurrence

KW - immunotherapy

KW - drug delivery

KW - hydrogel

KW - poly(I:C)

KW - Toll like receptor agonists

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DO - 10.26182/89kg-wx08

M3 - Doctoral Thesis

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Biomaterial-assisted delivery of immunotherapy: a novel approach to prevent cancer recurrence

Abstract

Embargo information

UN SDGs

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Projects

Interoperative immunotherapy to prevent relapse in soft tissue sarcoma

Research output

A mouse model of incompletely resected soft tissue sarcoma for testing (Neo)adjuvant therapies

Cite this