Biomaterial-assisted delivery of immunotherapy: a novel approach to prevent cancer recurrence

Research output: ThesisDoctoral Thesis

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Abstract

I aimed to tackle a clinical challenge of post-surgery cancer recurrence by developing a surgically
optimised hydrogel that could be applied in the wound after surgery to release immunotherapy and kill remaining cancer cells. I demonstrated that the immunotherapy hydrogel prevents cancer
recurrence in multiple preclinical models of surgery. I showed the safety and feasibility of the
immunotherapy hydrogel in a real-world oncological setting in a canine veterinary trial in pet dogs with sarcoma undergoing surgery. These data demonstrate a surgically optimised intraoperative immunotherapy gel that can be applied in the context of surgery to prevent cancer recurrence.
Original languageEnglish
QualificationDoctor of Philosophy
Awarding Institution
  • The University of Western Australia
Supervisors/Advisors
  • Swaminatha Iyer, Killugudi, Supervisor
  • Lesterhuis, Willem, Supervisor
  • Wylie, Ben, Supervisor
  • Zemek, Rachael, Supervisor
Thesis sponsors
Award date29 May 2023
DOIs
Publication statusUnpublished - 2023

Embargo information

  • Embargoed from 29/05/2023 to 17/05/2024. Made publicly available on 17/05/2024.

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