Biological underpinnings, mental health and gender-affirming medical interventions: An examination of urgent research priorities in transgender and gender non-conforming children and adolescents

Simone Mahfouda

doi:10.26182/hek3-8690

Biological underpinnings, mental health and gender-affirming medical interventions: An examination of urgent research priorities in transgender and gender non-conforming children and adolescents

Simone Mahfouda

School of Psychological Science

Research output: Thesis › Doctoral Thesis

583 Downloads (Pure)

Abstract

The aim of this multidisciplinary dissertation was to improve understanding of transgender and gender non-conforming populations, particularly children and adolescents. First, biological underpinnings were explored through longitudinal associations between androgen exposure in late gestation and gender nonconformity (GNC) in childhood and adolescence. Next, mental health outcomes of GNC were investigated for childhood, adolescence and adulthood. An additional study examined psychopathology and quality of life in transgender young people with autism, relative to transgender young people without autism. Finally, two systematic reviews investigated mental health outcomes and cognitive and physical effects for puberty suppression regimens and gender-affirming hormones and surgery.

Original language	English
Qualification	Doctor of Philosophy
Awarding Institution	The University of Western Australia
Supervisors/Advisors	Lin, Ashleigh, Supervisor Maybery, Murray, Supervisor Zepf, Florian, Supervisor
Thesis sponsors	Australian Government Research Training Program
Award date	22 Mar 2023
DOIs	https://doi.org/10.26182/hek3-8690
Publication status	Unpublished - 2023

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10.26182/hek3-8690

THESIS - DOCTOR OF PHILOSOPHY - MAHFOUDA Simone - 2023
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Gender-affirming hormones and surgery in transgender children and adolescents
Mahfouda, S., Moore, J. K., Siafarikas, A., Hewitt, T., Ganti, U., Lin, A. & Zepf, F. D., 1 Jun 2019, In: The Lancet Diabetes and Endocrinology. 7, 6, p. 484-498 15 p.
Research output: Contribution to journal › Review article › peer-review
136 Citations (Scopus)
Mental Health Correlates of Autism Spectrum Disorder in Gender Diverse Young People: Evidence from a Specialised Child and Adolescent Gender Clinic in Australia
Mahfouda, S., Panos, C., Whitehouse, A. J. O., Thomas, C. S., Maybery, M., Strauss, P., Zepf, F. D., O'Donovan, A., van Hall, H.-W., Saunders, L. A., Moore, J. K. & Lin, A., Oct 2019, In: Journal of Clinical Medicine. 8, 10, 14 p., 1503.
Research output: Contribution to journal › Article › peer-review

Open Access
55 Citations (Scopus)
Puberty suppression in transgender children and adolescents
Mahfouda, S., Moore, J. K., Siafarikas, A., Zepf, F. D. & Lin, A., Oct 2017, In: The Lancet Diabetes and Endocrinology. 5, 10, p. 816-826 11 p.
Research output: Contribution to journal › Review article › peer-review
110 Citations (Scopus)

Cite this

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title = "Biological underpinnings, mental health and gender-affirming medical interventions: An examination of urgent research priorities in transgender and gender non-conforming children and adolescents",

abstract = "The aim of this multidisciplinary dissertation was to improve understanding of transgender and gender non-conforming populations, particularly children and adolescents. First, biological underpinnings were explored through longitudinal associations between androgen exposure in late gestation and gender nonconformity (GNC) in childhood and adolescence. Next, mental health outcomes of GNC were investigated for childhood, adolescence and adulthood. An additional study examined psychopathology and quality of life in transgender young people with autism, relative to transgender young people without autism. Finally, two systematic reviews investigated mental health outcomes and cognitive and physical effects for puberty suppression regimens and gender-affirming hormones and surgery.",

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AB - The aim of this multidisciplinary dissertation was to improve understanding of transgender and gender non-conforming populations, particularly children and adolescents. First, biological underpinnings were explored through longitudinal associations between androgen exposure in late gestation and gender nonconformity (GNC) in childhood and adolescence. Next, mental health outcomes of GNC were investigated for childhood, adolescence and adulthood. An additional study examined psychopathology and quality of life in transgender young people with autism, relative to transgender young people without autism. Finally, two systematic reviews investigated mental health outcomes and cognitive and physical effects for puberty suppression regimens and gender-affirming hormones and surgery.

KW - transgender

KW - gender non-conforming

KW - hormones

KW - mental health

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KW - gender-affirming

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M3 - Doctoral Thesis

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Biological underpinnings, mental health and gender-affirming medical interventions: An examination of urgent research priorities in transgender and gender non-conforming children and adolescents

Abstract

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Research output

Gender-affirming hormones and surgery in transgender children and adolescents

Mental Health Correlates of Autism Spectrum Disorder in Gender Diverse Young People: Evidence from a Specialised Child and Adolescent Gender Clinic in Australia

Puberty suppression in transgender children and adolescents

Cite this