Traditional prostate radiotherapy involves conformal delivery of a spatially-uniform radiation dose to the whole prostate gland. While applying a focal dose escalation to macroscopic tumour identified on imaging is becoming popular, the dose prescription does not account for tumour biology heterogeneity. Biofocused radiotherapy (BiRT) has been proposed to optimise radiotherapy treatment planning using a tumour control probability (TCP) model and image-derived, patient-specific tumour biology maps to inform the model. This thesis aimed to apply the BiRT principles to prostate intensity-modulated radiotherapy (IMRT) and investigate the potential dosimetric benefits of biological optimisation using patient-specific, image-derived tumour biology distributions.
|Qualification||Doctor of Philosophy|
|Award date||9 Dec 2020|
|Publication status||Unpublished - 2020|
- Embargoed from 16/12/2020 to 01/01/2023. Made publicly available on 01/01/2023.