Biological interpretation of genome-wide association studies using predicted gene functions

T.H. Pers; J.M. Karjalainen; Y. Chan; H.J. Westra; A.R. Wood; J. Yang; J.C. Lui; S. Vedantam; S. Gustafsson; T. Esko; T. Frayling; E.K. Speliotes; M. Boehnke; S. Raychaudhuri; R.S.N. Fehrmann; J.N. Hirschhorn; L. Franke; AR Wood; T Esko; J Yang; S Vedantam; TH Pers; S Gustafsson; AY Chu; K Estrada; J Luan; Z Kutalik; N Amin; ML Buchkovich; D C Croteau-Chonka; FR Day; Y Duan; T Fall; R Fehrmann; T Ferreira; AU Jackson; J Karjalainen; KS Lo; AE Locke; R Magi; E Mihailov; E Porcu; JC Randall; A Seherag; A AE Vinkhuyzen; HJ Westra; TW Winkler; T Workalemahu; JH Zhao; D Absher; E. Albrecht; D Anderson; J Baron; M Beekman; A Demirkan; G Ehret; B Feensta; MF Feitosa; K Fischer; RM Fraser; A Goel; J Gong; AE Justice; S Kanoni; ME Kleber; k Kristiansson; U Lim; V Lotay; JC Lui; M Mangino; IM Leach; M Medina-Gomez; MA Nalls; DR Nyholt; CD Palmer; D Pasko; S Pechlivanis; I Prokopenko; JS Reid; S Ripke; D Shungin; A Stancakova; RJ Strawbridge; YJ Sung; T Tanaka; A Tuemer; S Trompet; S Van Der Laan; J Van Setten; JV Van Vliet-Ostaptchouk; Z Wang; L Yengo; W Zhang; U Afzal; J Arnlov; GM Arscott; S Bandinelli; A Barrett; C Bellis; AJ Bennett; C Berne; M Bluher; JL Bolton; Y Bottcher; H Boyd; M Bruineberg; BM Buckley; S Buyske; IH Caspersen; PS Chines; R Clarke; S Claudi-Boehm; M Cooper; E Warwick Daw; PA De Jong; D Deelen; G Delgado; JC Denny; R Dhonukshe-Rutten; M Dimitriou; A SF Doney; M Dorr; N Eklund; E Eury; L Folkersen; M E Garcia; F Geller; V Giedraitis; A S Go; H Grallert; TB Grammer; J Grassler; H Gronberg; L C.P.G.M De Groot; CJ Groves; J Haessler; P Hall; T Haller; G Hallmans; A Hannemann; CA Hartman; M Hassinen; C Hayward; N Heard-Costa; Q Helmer; G Hemani; A K Henders; HL Hillege; MA Hlatky; W Hoffmann; P Hoffmann; O Holmen; JJ Houwing-Duistermaat; T Illig; A Isaacs; AL James; J Jeff; B Johansen; A Johannson; J Jolley; T Juliusdottir; J Junttila; AN Kho; L Kinnunen; N Klopp; T Kocher; W Kratzer; P Lichtner; L Lind; J Lindstrom; S Lobbens; M Lorentzon; Y Lu; V Lyssenko; PKE Magnusson; A Mahajan; M Maillard; W Mcardle; CA Mckenzie; S Mclachlan; PJ Mclaren; G Menni; S Merger; L Milani; A Moayyeri; KL Monda; MA Morken; G Muller; M Muller-Nurasyid; AW Musk; N Narisu; M Nauck; I M Nolte; MM Nothen; L Oozageer; S Pilz; NW Rayner; F Renstrom; NR Robertson; R Roussel; S Sanna; H Scharnagl; S Scholtens; FR Schumacher; H Schunkert; J Sehmi; T Seufferlein; J Shi; K Silventoinen; JH Smit; AV Smith; J Smolonska; AV Stanton; K Stirrups; DJ Stott; HJ Stringham; J Sundstrom; MA Swertz; AC Syvanen; B O Tayo; G Thorleifsson; JP Tyrer; S Van Dijk; N Van Schoor; N Van Der Velde; D Van Heemst; F VA Van Oort; SH Vermeulen; N Verweij; JM Vonk; LM Waite; M Waldenberger; R Wennauer; LR Wilkens; C Willenborg; T Wilsgaard; MK Wojczynski; A Wong; A Wright; Q Zhang; D Arveiler; S JL Bakker; John Beilby; RN Bergman; S Bergmann; R Biffar; J Blangero; DI Boomsma; SR Bornstein; P Bovet; P Brambilla; H Campbell; MJ Caulfield; A Chakravarti; R Collins; FS Collins; Dana C. Crawford; LA Cupples; J Danesh; U De Faire; HM Den Ruijter; R Erbel; J Erdmann; JG Eriksson; M Farrall; E Ferrannini; J Ferrieres; I Ford; NG Forouhi; T Forrrester; RT Gansevoort; PV Gejman; C Gieger; A Golay; O Gottesman; V Gudnason; U Gyllensten; DW Haas; AS Hall; TB Harris; AT Hattersley; AC Heath; C Hengstenberg; AA Hicks; LA Hindorff; AD Hingorani; A Hofman; GK Hovingh; SE Humphries; SC Hunt; A Hypponen; KB Jacobs; MR Jarvelin; P Jousilahti; AM Jula; J Kaprio; J JP Kastelein; M Kayser; F Kee; SM Keinanen-Kuikaanniemi; LA Kiemeny; JS Kooner; C Kooperberg; S Koskinen; P Kovacs; AT Kraja; M Kumari; J Kuusisto; TA Lakka; C Langenberg; L Le Marchand; T Lehtimaki; S Lupoli; P AF Madden; S Mannisto; P Manunta; A Marette; TC Matise; B Mcknight; T Meitinger; FL Moll; GW Montgomery; AD Morris; AP Morris; AC Murray; M Nelis; C Ohlsson; AJ Oldehinkel; KK Ong; WH Ouwehand; G Pasterkamp; A Peters; PP Pramstaller; l Qi; OT Raitakari; T Rankinen; DC Rao; TK Rice; M Ritchie; I Rudan; V Salomaa; NJ Samani; J Saramies; MA Sarzynski; P EH Schwarz; S Sebert; P Sever; AR Schuldiner; J Sinisalo; V Steinthorsdittor; RP Stolk; J-C Tardif; A Tonjes; A Tremblay; E Tremoli; J Virtamo; M-C Vohl; P Amouyel; FW Asselbergs; TL Assimes; M Bochud; BO Boehm; E Boerwinkle; E P Bottinger; C Bouchard; S Cauchi; JC Chambers; SJ Chanock; RS Cooper; P IW De Bakker; G Dedoussis; L Ferrucci; PW Franks; P Frougel; LC Groop; CA Haimann; A Hamsten; M Geoffrey Hayes; Jennie Hui; DJ Hunter; K Hveem; J W Jukema; RC Kaplan; M Kivimaki; D Kuh; M Laakso; Y Liu; NG Martin; W Marz; M Melbye; S Moebus; PB Munroe; I Njolstad; BA Oostra; C NA Palmer; NL Pedersen; M Perola; L Perusse; U Peters; JE Powell; C Power; T Quatermous; R Rauramaa; E Reinmaa; PM Ridker; F Rivadeneira; PE Slagboom; H Snieder; TD Spector; K Strauch; M Stumvoll; J Tuomilehto; M Uusitupa; P Van Der Harst; H Volzke; M Walker; NJ Wareham; H Watkins; H-E Wichmann; JF Wilson; P Zanen; P Deloukas; I M Heid; C M Lindgren; KL Mohlke; EK Speilotes; U Thjorsteinsdottir; I Barroso; C S Fox; K E North; DP Strachan; J S Beckman; SI Berndt; M Boehnke; IB Borecki; M I Mccarthy; A Metspalu; K Stefansson; A G Uitterlinden; CM Van Duijn; L Franke; CJ Willer; A L Price; G Lettre; R JF Loos; MN Weedon; J O'Connell; GR Abecasis; DI Chasman; ME Goddard; PM Visscher; JN Hirschhorn; TM Frayling

doi:10.1038/ncomms6890

Biological interpretation of genome-wide association studies using predicted gene functions

T.H. Pers, J.M. Karjalainen, Y. Chan, H.J. Westra, A.R. Wood, J. Yang, J.C. Lui, S. Vedantam, S. Gustafsson, T. Esko, T. Frayling, E.K. Speliotes, M. Boehnke, S. Raychaudhuri, R.S.N. Fehrmann, J.N. Hirschhorn, L. Franke, AR Wood, T Esko, J YangS Vedantam, TH Pers, S Gustafsson, AY Chu, K Estrada, J Luan, Z Kutalik, N Amin, ML Buchkovich, D C Croteau-Chonka, FR Day, Y Duan, T Fall, R Fehrmann, T Ferreira, AU Jackson, J Karjalainen, KS Lo, AE Locke, R Magi, E Mihailov, E Porcu, JC Randall, A Seherag, A AE Vinkhuyzen, HJ Westra, TW Winkler, T Workalemahu, JH Zhao, D Absher, E. Albrecht, D Anderson, J Baron, M Beekman, A Demirkan, G Ehret, B Feensta, MF Feitosa, K Fischer, RM Fraser, A Goel, J Gong, AE Justice, S Kanoni, ME Kleber, k Kristiansson, U Lim, V Lotay, JC Lui, M Mangino, IM Leach, M Medina-Gomez, MA Nalls, DR Nyholt, CD Palmer, D Pasko, S Pechlivanis, I Prokopenko, JS Reid, S Ripke, D Shungin, A Stancakova, RJ Strawbridge, YJ Sung, T Tanaka, A Tuemer, S Trompet, S Van Der Laan, J Van Setten, JV Van Vliet-Ostaptchouk, Z Wang, L Yengo, W Zhang, U Afzal, J Arnlov, GM Arscott, S Bandinelli, A Barrett, C Bellis, AJ Bennett, C Berne, M Bluher, JL Bolton, Y Bottcher, H Boyd, M Bruineberg, BM Buckley, S Buyske, IH Caspersen, PS Chines, R Clarke, S Claudi-Boehm, M Cooper, E Warwick Daw, PA De Jong, D Deelen, G Delgado, JC Denny, R Dhonukshe-Rutten, M Dimitriou, A SF Doney, M Dorr, N Eklund, E Eury, L Folkersen, M E Garcia, F Geller, V Giedraitis, A S Go, H Grallert, TB Grammer, J Grassler, H Gronberg, L C.P.G.M De Groot, CJ Groves, J Haessler, P Hall, T Haller, G Hallmans, A Hannemann, CA Hartman, M Hassinen, C Hayward, N Heard-Costa, Q Helmer, G Hemani, A K Henders, HL Hillege, MA Hlatky, W Hoffmann, P Hoffmann, O Holmen, JJ Houwing-Duistermaat, T Illig, A Isaacs, AL James, J Jeff, B Johansen, A Johannson, J Jolley, T Juliusdottir, J Junttila, AN Kho, L Kinnunen, N Klopp, T Kocher, W Kratzer, P Lichtner, L Lind, J Lindstrom, S Lobbens, M Lorentzon, Y Lu, V Lyssenko, PKE Magnusson, A Mahajan, M Maillard, W Mcardle, CA Mckenzie, S Mclachlan, PJ Mclaren, G Menni, S Merger, L Milani, A Moayyeri, KL Monda, MA Morken, G Muller, M Muller-Nurasyid, AW Musk, N Narisu, M Nauck, I M Nolte, MM Nothen, L Oozageer, S Pilz, NW Rayner, F Renstrom, NR Robertson, R Roussel, S Sanna, H Scharnagl, S Scholtens, FR Schumacher, H Schunkert, J Sehmi, T Seufferlein, J Shi, K Silventoinen, JH Smit, AV Smith, J Smolonska, AV Stanton, K Stirrups, DJ Stott, HJ Stringham, J Sundstrom, MA Swertz, AC Syvanen, B O Tayo, G Thorleifsson, JP Tyrer, S Van Dijk, N Van Schoor, N Van Der Velde, D Van Heemst, F VA Van Oort, SH Vermeulen, N Verweij, JM Vonk, LM Waite, M Waldenberger, R Wennauer, LR Wilkens, C Willenborg, T Wilsgaard, MK Wojczynski, A Wong, A Wright, Q Zhang, D Arveiler, S JL Bakker, John Beilby, RN Bergman, S Bergmann, R Biffar, J Blangero, DI Boomsma, SR Bornstein, P Bovet, P Brambilla, H Campbell, MJ Caulfield, A Chakravarti, R Collins, FS Collins, Dana C. Crawford, LA Cupples, J Danesh, U De Faire, HM Den Ruijter, R Erbel, J Erdmann, JG Eriksson, M Farrall, E Ferrannini, J Ferrieres, I Ford, NG Forouhi, T Forrrester, RT Gansevoort, PV Gejman, C Gieger, A Golay, O Gottesman, V Gudnason, U Gyllensten, DW Haas, AS Hall, TB Harris, AT Hattersley, AC Heath, C Hengstenberg, AA Hicks, LA Hindorff, AD Hingorani, A Hofman, GK Hovingh, SE Humphries, SC Hunt, A Hypponen, KB Jacobs, MR Jarvelin, P Jousilahti, AM Jula, J Kaprio, J JP Kastelein, M Kayser, F Kee, SM Keinanen-Kuikaanniemi, LA Kiemeny, JS Kooner, C Kooperberg, S Koskinen, P Kovacs, AT Kraja, M Kumari, J Kuusisto, TA Lakka, C Langenberg, L Le Marchand, T Lehtimaki, S Lupoli, P AF Madden, S Mannisto, P Manunta, A Marette, TC Matise, B Mcknight, T Meitinger, FL Moll, GW Montgomery, AD Morris, AP Morris, AC Murray, M Nelis, C Ohlsson, AJ Oldehinkel, KK Ong, WH Ouwehand, G Pasterkamp, A Peters, PP Pramstaller, l Qi, OT Raitakari, T Rankinen, DC Rao, TK Rice, M Ritchie, I Rudan, V Salomaa, NJ Samani, J Saramies, MA Sarzynski, P EH Schwarz, S Sebert, P Sever, AR Schuldiner, J Sinisalo, V Steinthorsdittor, RP Stolk, J-C Tardif, A Tonjes, A Tremblay, E Tremoli, J Virtamo, M-C Vohl, P Amouyel, FW Asselbergs, TL Assimes, M Bochud, BO Boehm, E Boerwinkle, E P Bottinger, C Bouchard, S Cauchi, JC Chambers, SJ Chanock, RS Cooper, P IW De Bakker, G Dedoussis, L Ferrucci, PW Franks, P Frougel, LC Groop, CA Haimann, A Hamsten, M Geoffrey Hayes, Jennie Hui, DJ Hunter, K Hveem, J W Jukema, RC Kaplan, M Kivimaki, D Kuh, M Laakso, Y Liu, NG Martin, W Marz, M Melbye, S Moebus, PB Munroe, I Njolstad, BA Oostra, C NA Palmer, NL Pedersen, M Perola, L Perusse, U Peters, JE Powell, C Power, T Quatermous, R Rauramaa, E Reinmaa, PM Ridker, F Rivadeneira, PE Slagboom, H Snieder, TD Spector, K Strauch, M Stumvoll, J Tuomilehto, M Uusitupa, P Van Der Harst, H Volzke, M Walker, NJ Wareham, H Watkins, H-E Wichmann, JF Wilson, P Zanen, P Deloukas, I M Heid, C M Lindgren, KL Mohlke, EK Speilotes, U Thjorsteinsdottir, I Barroso, C S Fox, K E North, DP Strachan, J S Beckman, SI Berndt, M Boehnke, IB Borecki, M I Mccarthy, A Metspalu, K Stefansson, A G Uitterlinden, CM Van Duijn, L Franke, CJ Willer, A L Price, G Lettre, R JF Loos, MN Weedon, J O'Connell, GR Abecasis, DI Chasman, ME Goddard, PM Visscher, JN Hirschhorn, TM Frayling

Research output: Contribution to journal › Article › peer-review

529 Citations (Scopus)

Abstract

© 2015 Macmillan Publishers Limited. All rights reserved. The main challenge for gaining biological insights from genetic associations is identifying which genes and pathways explain the associations. Here we present DEPICT, an integrative tool that employs predicted gene functions to systematically prioritize the most likely causal genes at associated loci, highlight enriched pathways and identify tissues/cell types where genes from associated loci are highly expressed. DEPICT is not limited to genes with established functions and prioritizes relevant gene sets for many phenotypes.

Original language	English
Pages (from-to)	1-6
Journal	Nature Communications
Volume	6
DOIs	https://doi.org/10.1038/ncomms6890
Publication status	Published - 2015

Access to Document

10.1038/ncomms6890

Cite this

Pers, T. H., Karjalainen, J. M., Chan, Y., Westra, H. J., Wood, A. R., Yang, J., Lui, J. C., Vedantam, S., Gustafsson, S., Esko, T., Frayling, T., Speliotes, E. K., Boehnke, M., Raychaudhuri, S., Fehrmann, R. S. N., Hirschhorn, J. N., Franke, L., Wood, AR., Esko, T., ... Frayling, TM. (2015). Biological interpretation of genome-wide association studies using predicted gene functions. Nature Communications, 6, 1-6. https://doi.org/10.1038/ncomms6890

@article{f1e0dc299c044e00b6147fdd133f8d26,

title = "Biological interpretation of genome-wide association studies using predicted gene functions",

abstract = "{\textcopyright} 2015 Macmillan Publishers Limited. All rights reserved. The main challenge for gaining biological insights from genetic associations is identifying which genes and pathways explain the associations. Here we present DEPICT, an integrative tool that employs predicted gene functions to systematically prioritize the most likely causal genes at associated loci, highlight enriched pathways and identify tissues/cell types where genes from associated loci are highly expressed. DEPICT is not limited to genes with established functions and prioritizes relevant gene sets for many phenotypes.",

author = "T.H. Pers and J.M. Karjalainen and Y. Chan and H.J. Westra and A.R. Wood and J. Yang and J.C. Lui and S. Vedantam and S. Gustafsson and T. Esko and T. Frayling and E.K. Speliotes and M. Boehnke and S. Raychaudhuri and R.S.N. Fehrmann and J.N. Hirschhorn and L. Franke and AR Wood and T Esko and J Yang and S Vedantam and TH Pers and S Gustafsson and AY Chu and K Estrada and J Luan and Z Kutalik and N Amin and ML Buchkovich and Croteau-Chonka, {D C} and FR Day and Y Duan and T Fall and R Fehrmann and T Ferreira and AU Jackson and J Karjalainen and KS Lo and AE Locke and R Magi and E Mihailov and E Porcu and JC Randall and A Seherag and Vinkhuyzen, {A AE} and HJ Westra and TW Winkler and T Workalemahu and JH Zhao and D Absher and E. Albrecht and D Anderson and J Baron and M Beekman and A Demirkan and G Ehret and B Feensta and MF Feitosa and K Fischer and RM Fraser and A Goel and J Gong and AE Justice and S Kanoni and ME Kleber and k Kristiansson and U Lim and V Lotay and JC Lui and M Mangino and IM Leach and M Medina-Gomez and MA Nalls and DR Nyholt and CD Palmer and D Pasko and S Pechlivanis and I Prokopenko and JS Reid and S Ripke and D Shungin and A Stancakova and RJ Strawbridge and YJ Sung and T Tanaka and A Tuemer and S Trompet and {Van Der Laan}, S and {Van Setten}, J and {Van Vliet-Ostaptchouk}, JV and Z Wang and L Yengo and W Zhang and U Afzal and J Arnlov and GM Arscott and S Bandinelli and A Barrett and C Bellis and AJ Bennett and C Berne and M Bluher and JL Bolton and Y Bottcher and H Boyd and M Bruineberg and BM Buckley and S Buyske and IH Caspersen and PS Chines and R Clarke and S Claudi-Boehm and M Cooper and {Warwick Daw}, E and {De Jong}, PA and D Deelen and G Delgado and JC Denny and R Dhonukshe-Rutten and M Dimitriou and Doney, {A SF} and M Dorr and N Eklund and E Eury and L Folkersen and Garcia, {M E} and F Geller and V Giedraitis and Go, {A S} and H Grallert and TB Grammer and J Grassler and H Gronberg and {De Groot}, {L C.P.G.M} and CJ Groves and J Haessler and P Hall and T Haller and G Hallmans and A Hannemann and CA Hartman and M Hassinen and C Hayward and N Heard-Costa and Q Helmer and G Hemani and Henders, {A K} and HL Hillege and MA Hlatky and W Hoffmann and P Hoffmann and O Holmen and JJ Houwing-Duistermaat and T Illig and A Isaacs and AL James and J Jeff and B Johansen and A Johannson and J Jolley and T Juliusdottir and J Junttila and AN Kho and L Kinnunen and N Klopp and T Kocher and W Kratzer and P Lichtner and L Lind and J Lindstrom and S Lobbens and M Lorentzon and Y Lu and V Lyssenko and PKE Magnusson and A Mahajan and M Maillard and W Mcardle and CA Mckenzie and S Mclachlan and PJ Mclaren and G Menni and S Merger and L Milani and A Moayyeri and KL Monda and MA Morken and G Muller and M Muller-Nurasyid and AW Musk and N Narisu and M Nauck and Nolte, {I M} and MM Nothen and L Oozageer and S Pilz and NW Rayner and F Renstrom and NR Robertson and R Roussel and S Sanna and H Scharnagl and S Scholtens and FR Schumacher and H Schunkert and J Sehmi and T Seufferlein and J Shi and K Silventoinen and JH Smit and AV Smith and J Smolonska and AV Stanton and K Stirrups and DJ Stott and HJ Stringham and J Sundstrom and MA Swertz and AC Syvanen and Tayo, {B O} and G Thorleifsson and JP Tyrer and {Van Dijk}, S and {Van Schoor}, N and {Van Der Velde}, N and {Van Heemst}, D and {Van Oort}, {F VA} and SH Vermeulen and N Verweij and JM Vonk and LM Waite and M Waldenberger and R Wennauer and LR Wilkens and C Willenborg and T Wilsgaard and MK Wojczynski and A Wong and A Wright and Q Zhang and D Arveiler and Bakker, {S JL} and John Beilby and RN Bergman and S Bergmann and R Biffar and J Blangero and DI Boomsma and SR Bornstein and P Bovet and P Brambilla and H Campbell and MJ Caulfield and A Chakravarti and R Collins and FS Collins and Crawford, {Dana C.} and LA Cupples and J Danesh and {De Faire}, U and {Den Ruijter}, HM and R Erbel and J Erdmann and JG Eriksson and M Farrall and E Ferrannini and J Ferrieres and I Ford and NG Forouhi and T Forrrester and RT Gansevoort and PV Gejman and C Gieger and A Golay and O Gottesman and V Gudnason and U Gyllensten and DW Haas and AS Hall and TB Harris and AT Hattersley and AC Heath and C Hengstenberg and AA Hicks and LA Hindorff and AD Hingorani and A Hofman and GK Hovingh and SE Humphries and SC Hunt and A Hypponen and KB Jacobs and MR Jarvelin and P Jousilahti and AM Jula and J Kaprio and Kastelein, {J JP} and M Kayser and F Kee and SM Keinanen-Kuikaanniemi and LA Kiemeny and JS Kooner and C Kooperberg and S Koskinen and P Kovacs and AT Kraja and M Kumari and J Kuusisto and TA Lakka and C Langenberg and {Le Marchand}, L and T Lehtimaki and S Lupoli and Madden, {P AF} and S Mannisto and P Manunta and A Marette and TC Matise and B Mcknight and T Meitinger and FL Moll and GW Montgomery and AD Morris and AP Morris and AC Murray and M Nelis and C Ohlsson and AJ Oldehinkel and KK Ong and WH Ouwehand and G Pasterkamp and A Peters and PP Pramstaller and l Qi and OT Raitakari and T Rankinen and DC Rao and TK Rice and M Ritchie and I Rudan and V Salomaa and NJ Samani and J Saramies and MA Sarzynski and Schwarz, {P EH} and S Sebert and P Sever and AR Schuldiner and J Sinisalo and V Steinthorsdittor and RP Stolk and J-C Tardif and A Tonjes and A Tremblay and E Tremoli and J Virtamo and M-C Vohl and P Amouyel and FW Asselbergs and TL Assimes and M Bochud and BO Boehm and E Boerwinkle and Bottinger, {E P} and C Bouchard and S Cauchi and JC Chambers and SJ Chanock and RS Cooper and {De Bakker}, {P IW} and G Dedoussis and L Ferrucci and PW Franks and P Frougel and LC Groop and CA Haimann and A Hamsten and {Geoffrey Hayes}, M and Jennie Hui and DJ Hunter and K Hveem and Jukema, {J W} and RC Kaplan and M Kivimaki and D Kuh and M Laakso and Y Liu and NG Martin and W Marz and M Melbye and S Moebus and PB Munroe and I Njolstad and BA Oostra and Palmer, {C NA} and NL Pedersen and M Perola and L Perusse and U Peters and JE Powell and C Power and T Quatermous and R Rauramaa and E Reinmaa and PM Ridker and F Rivadeneira and PE Slagboom and H Snieder and TD Spector and K Strauch and M Stumvoll and J Tuomilehto and M Uusitupa and {Van Der Harst}, P and H Volzke and M Walker and NJ Wareham and H Watkins and H-E Wichmann and JF Wilson and P Zanen and P Deloukas and Heid, {I M} and Lindgren, {C M} and KL Mohlke and EK Speilotes and U Thjorsteinsdottir and I Barroso and Fox, {C S} and North, {K E} and DP Strachan and Beckman, {J S} and SI Berndt and M Boehnke and IB Borecki and Mccarthy, {M I} and A Metspalu and K Stefansson and Uitterlinden, {A G} and {Van Duijn}, CM and L Franke and CJ Willer and Price, {A L} and G Lettre and Loos, {R JF} and MN Weedon and J O'Connell and GR Abecasis and DI Chasman and ME Goddard and PM Visscher and JN Hirschhorn and TM Frayling",

year = "2015",

doi = "10.1038/ncomms6890",

language = "English",

volume = "6",

pages = "1--6",

journal = "Nature Communications",

issn = "2041-1723",

publisher = "Nature Publishing Group - Macmillan Publishers",

}

Pers, TH, Karjalainen, JM, Chan, Y, Westra, HJ, Wood, AR, Yang, J, Lui, JC, Vedantam, S, Gustafsson, S, Esko, T, Frayling, T, Speliotes, EK, Boehnke, M, Raychaudhuri, S, Fehrmann, RSN, Hirschhorn, JN, Franke, L, Wood, AR, Esko, T, Yang, J, Vedantam, S, Pers, TH, Gustafsson, S, Chu, AY, Estrada, K, Luan, J, Kutalik, Z, Amin, N, Buchkovich, ML, Croteau-Chonka, DC, Day, FR, Duan, Y, Fall, T, Fehrmann, R, Ferreira, T, Jackson, AU, Karjalainen, J, Lo, KS, Locke, AE, Magi, R, Mihailov, E, Porcu, E, Randall, JC, Seherag, A, Vinkhuyzen, AAE, Westra, HJ, Winkler, TW, Workalemahu, T, Zhao, JH, Absher, D, Albrecht, E, Anderson, D, Baron, J, Beekman, M, Demirkan, A, Ehret, G, Feensta, B, Feitosa, MF, Fischer, K, Fraser, RM, Goel, A, Gong, J, Justice, AE, Kanoni, S, Kleber, ME, Kristiansson, K, Lim, U, Lotay, V, Lui, JC, Mangino, M, Leach, IM, Medina-Gomez, M, Nalls, MA, Nyholt, DR, Palmer, CD, Pasko, D, Pechlivanis, S, Prokopenko, I, Reid, JS, Ripke, S, Shungin, D, Stancakova, A, Strawbridge, RJ, Sung, YJ, Tanaka, T, Tuemer, A, Trompet, S, Van Der Laan, S, Van Setten, J, Van Vliet-Ostaptchouk, JV, Wang, Z, Yengo, L, Zhang, W, Afzal, U, Arnlov, J, Arscott, GM, Bandinelli, S, Barrett, A, Bellis, C, Bennett, AJ, Berne, C, Bluher, M, Bolton, JL, Bottcher, Y, Boyd, H, Bruineberg, M, Buckley, BM, Buyske, S, Caspersen, IH, Chines, PS, Clarke, R, Claudi-Boehm, S, Cooper, M, Warwick Daw, E, De Jong, PA, Deelen, D, Delgado, G, Denny, JC, Dhonukshe-Rutten, R, Dimitriou, M, Doney, ASF, Dorr, M, Eklund, N, Eury, E, Folkersen, L, Garcia, ME, Geller, F, Giedraitis, V, Go, AS, Grallert, H, Grammer, TB, Grassler, J, Gronberg, H, De Groot, LCPGM, Groves, CJ, Haessler, J, Hall, P, Haller, T, Hallmans, G, Hannemann, A, Hartman, CA, Hassinen, M, Hayward, C, Heard-Costa, N, Helmer, Q, Hemani, G, Henders, AK, Hillege, HL, Hlatky, MA, Hoffmann, W, Hoffmann, P, Holmen, O, Houwing-Duistermaat, JJ, Illig, T, Isaacs, A, James, AL, Jeff, J, Johansen, B, Johannson, A, Jolley, J, Juliusdottir, T, Junttila, J, Kho, AN, Kinnunen, L, Klopp, N, Kocher, T, Kratzer, W, Lichtner, P, Lind, L, Lindstrom, J, Lobbens, S, Lorentzon, M, Lu, Y, Lyssenko, V, Magnusson, PKE, Mahajan, A, Maillard, M, Mcardle, W, Mckenzie, CA, Mclachlan, S, Mclaren, PJ, Menni, G, Merger, S, Milani, L, Moayyeri, A, Monda, KL, Morken, MA, Muller, G, Muller-Nurasyid, M, Musk, AW, Narisu, N, Nauck, M, Nolte, IM, Nothen, MM, Oozageer, L, Pilz, S, Rayner, NW, Renstrom, F, Robertson, NR, Roussel, R, Sanna, S, Scharnagl, H, Scholtens, S, Schumacher, FR, Schunkert, H, Sehmi, J, Seufferlein, T, Shi, J, Silventoinen, K, Smit, JH, Smith, AV, Smolonska, J, Stanton, AV, Stirrups, K, Stott, DJ, Stringham, HJ, Sundstrom, J, Swertz, MA, Syvanen, AC, Tayo, BO, Thorleifsson, G, Tyrer, JP, Van Dijk, S, Van Schoor, N, Van Der Velde, N, Van Heemst, D, Van Oort, FVA, Vermeulen, SH, Verweij, N, Vonk, JM, Waite, LM, Waldenberger, M, Wennauer, R, Wilkens, LR, Willenborg, C, Wilsgaard, T, Wojczynski, MK, Wong, A, Wright, A, Zhang, Q, Arveiler, D, Bakker, SJL, Beilby, J, Bergman, RN, Bergmann, S, Biffar, R, Blangero, J, Boomsma, DI, Bornstein, SR, Bovet, P, Brambilla, P, Campbell, H, Caulfield, MJ, Chakravarti, A, Collins, R, Collins, FS, Crawford, DC, Cupples, LA, Danesh, J, De Faire, U, Den Ruijter, HM, Erbel, R, Erdmann, J, Eriksson, JG, Farrall, M, Ferrannini, E, Ferrieres, J, Ford, I, Forouhi, NG, Forrrester, T, Gansevoort, RT, Gejman, PV, Gieger, C, Golay, A, Gottesman, O, Gudnason, V, Gyllensten, U, Haas, DW, Hall, AS, Harris, TB, Hattersley, AT, Heath, AC, Hengstenberg, C, Hicks, AA, Hindorff, LA, Hingorani, AD, Hofman, A, Hovingh, GK, Humphries, SE, Hunt, SC, Hypponen, A, Jacobs, KB, Jarvelin, MR, Jousilahti, P, Jula, AM, Kaprio, J, Kastelein, JJP, Kayser, M, Kee, F, Keinanen-Kuikaanniemi, SM, Kiemeny, LA, Kooner, JS, Kooperberg, C, Koskinen, S, Kovacs, P, Kraja, AT, Kumari, M, Kuusisto, J, Lakka, TA, Langenberg, C, Le Marchand, L, Lehtimaki, T, Lupoli, S, Madden, PAF, Mannisto, S, Manunta, P, Marette, A, Matise, TC, Mcknight, B, Meitinger, T, Moll, FL, Montgomery, GW, Morris, AD, Morris, AP, Murray, AC, Nelis, M, Ohlsson, C, Oldehinkel, AJ, Ong, KK, Ouwehand, WH, Pasterkamp, G, Peters, A, Pramstaller, PP, Qi, L, Raitakari, OT, Rankinen, T, Rao, DC, Rice, TK, Ritchie, M, Rudan, I, Salomaa, V, Samani, NJ, Saramies, J, Sarzynski, MA, Schwarz, PEH, Sebert, S, Sever, P, Schuldiner, AR, Sinisalo, J, Steinthorsdittor, V, Stolk, RP, Tardif, J-C, Tonjes, A, Tremblay, A, Tremoli, E, Virtamo, J, Vohl, M-C, Amouyel, P, Asselbergs, FW, Assimes, TL, Bochud, M, Boehm, BO, Boerwinkle, E, Bottinger, EP, Bouchard, C, Cauchi, S, Chambers, JC, Chanock, SJ, Cooper, RS, De Bakker, PIW, Dedoussis, G, Ferrucci, L, Franks, PW, Frougel, P, Groop, LC, Haimann, CA, Hamsten, A, Geoffrey Hayes, M, Hui, J, Hunter, DJ, Hveem, K, Jukema, JW, Kaplan, RC, Kivimaki, M, Kuh, D, Laakso, M, Liu, Y, Martin, NG, Marz, W, Melbye, M, Moebus, S, Munroe, PB, Njolstad, I, Oostra, BA, Palmer, CNA, Pedersen, NL, Perola, M, Perusse, L, Peters, U, Powell, JE, Power, C, Quatermous, T, Rauramaa, R, Reinmaa, E, Ridker, PM, Rivadeneira, F, Slagboom, PE, Snieder, H, Spector, TD, Strauch, K, Stumvoll, M, Tuomilehto, J, Uusitupa, M, Van Der Harst, P, Volzke, H, Walker, M, Wareham, NJ, Watkins, H, Wichmann, H-E, Wilson, JF, Zanen, P, Deloukas, P, Heid, IM, Lindgren, CM, Mohlke, KL, Speilotes, EK, Thjorsteinsdottir, U, Barroso, I, Fox, CS, North, KE, Strachan, DP, Beckman, JS, Berndt, SI, Boehnke, M, Borecki, IB, Mccarthy, MI, Metspalu, A, Stefansson, K, Uitterlinden, AG, Van Duijn, CM, Franke, L, Willer, CJ, Price, AL, Lettre, G, Loos, RJF, Weedon, MN, O'Connell, J, Abecasis, GR, Chasman, DI, Goddard, ME, Visscher, PM, Hirschhorn, JN & Frayling, TM 2015, 'Biological interpretation of genome-wide association studies using predicted gene functions', Nature Communications, vol. 6, pp. 1-6. https://doi.org/10.1038/ncomms6890

TY - JOUR

T1 - Biological interpretation of genome-wide association studies using predicted gene functions

AU - Pers, T.H.

AU - Karjalainen, J.M.

AU - Chan, Y.

AU - Westra, H.J.

AU - Wood, A.R.

AU - Yang, J.

AU - Lui, J.C.

AU - Vedantam, S.

AU - Gustafsson, S.

AU - Esko, T.

AU - Frayling, T.

AU - Speliotes, E.K.

AU - Boehnke, M.

AU - Raychaudhuri, S.

AU - Fehrmann, R.S.N.

AU - Hirschhorn, J.N.

AU - Franke, L.

AU - Wood, AR

AU - Esko, T

AU - Yang, J

AU - Vedantam, S

AU - Pers, TH

AU - Gustafsson, S

AU - Chu, AY

AU - Estrada, K

AU - Luan, J

AU - Kutalik, Z

AU - Amin, N

AU - Buchkovich, ML

AU - Croteau-Chonka, D C

AU - Day, FR

AU - Duan, Y

AU - Fall, T

AU - Fehrmann, R

AU - Ferreira, T

AU - Jackson, AU

AU - Karjalainen, J

AU - Lo, KS

AU - Locke, AE

AU - Magi, R

AU - Mihailov, E

AU - Porcu, E

AU - Randall, JC

AU - Seherag, A

AU - Vinkhuyzen, A AE

AU - Westra, HJ

AU - Winkler, TW

AU - Workalemahu, T

AU - Zhao, JH

AU - Absher, D

AU - Albrecht, E.

AU - Anderson, D

AU - Baron, J

AU - Beekman, M

AU - Demirkan, A

AU - Ehret, G

AU - Feensta, B

AU - Feitosa, MF

AU - Fischer, K

AU - Fraser, RM

AU - Goel, A

AU - Gong, J

AU - Justice, AE

AU - Kanoni, S

AU - Kleber, ME

AU - Kristiansson, k

AU - Lim, U

AU - Lotay, V

AU - Lui, JC

AU - Mangino, M

AU - Leach, IM

AU - Medina-Gomez, M

AU - Nalls, MA

AU - Nyholt, DR

AU - Palmer, CD

AU - Pasko, D

AU - Pechlivanis, S

AU - Prokopenko, I

AU - Reid, JS

AU - Ripke, S

AU - Shungin, D

AU - Stancakova, A

AU - Strawbridge, RJ

AU - Sung, YJ

AU - Tanaka, T

AU - Tuemer, A

AU - Trompet, S

AU - Van Der Laan, S

AU - Van Setten, J

AU - Van Vliet-Ostaptchouk, JV

AU - Wang, Z

AU - Yengo, L

AU - Zhang, W

AU - Afzal, U

AU - Arnlov, J

AU - Arscott, GM

AU - Bandinelli, S

AU - Barrett, A

AU - Bellis, C

AU - Bennett, AJ

AU - Berne, C

AU - Bluher, M

AU - Bolton, JL

AU - Bottcher, Y

AU - Boyd, H

AU - Bruineberg, M

AU - Buckley, BM

AU - Buyske, S

AU - Caspersen, IH

AU - Chines, PS

AU - Clarke, R

AU - Claudi-Boehm, S

AU - Cooper, M

AU - Warwick Daw, E

AU - De Jong, PA

AU - Deelen, D

AU - Delgado, G

AU - Denny, JC

AU - Dhonukshe-Rutten, R

AU - Dimitriou, M

AU - Doney, A SF

AU - Dorr, M

AU - Eklund, N

AU - Eury, E

AU - Folkersen, L

AU - Garcia, M E

AU - Geller, F

AU - Giedraitis, V

AU - Go, A S

AU - Grallert, H

AU - Grammer, TB

AU - Grassler, J

AU - Gronberg, H

AU - De Groot, L C.P.G.M

AU - Groves, CJ

AU - Haessler, J

AU - Hall, P

AU - Haller, T

AU - Hallmans, G

AU - Hannemann, A

AU - Hartman, CA

AU - Hassinen, M

AU - Hayward, C

AU - Heard-Costa, N

AU - Helmer, Q

AU - Hemani, G

AU - Henders, A K

AU - Hillege, HL

AU - Hlatky, MA

AU - Hoffmann, W

AU - Hoffmann, P

AU - Holmen, O

AU - Houwing-Duistermaat, JJ

AU - Illig, T

AU - Isaacs, A

AU - James, AL

AU - Jeff, J

AU - Johansen, B

AU - Johannson, A

AU - Jolley, J

AU - Juliusdottir, T

AU - Junttila, J

AU - Kho, AN

AU - Kinnunen, L

AU - Klopp, N

AU - Kocher, T

AU - Kratzer, W

AU - Lichtner, P

AU - Lind, L

AU - Lindstrom, J

AU - Lobbens, S

AU - Lorentzon, M

AU - Lu, Y

AU - Lyssenko, V

AU - Magnusson, PKE

AU - Mahajan, A

AU - Maillard, M

AU - Mcardle, W

AU - Mckenzie, CA

AU - Mclachlan, S

AU - Mclaren, PJ

AU - Menni, G

AU - Merger, S

AU - Milani, L

AU - Moayyeri, A

AU - Monda, KL

AU - Morken, MA

AU - Muller, G

AU - Muller-Nurasyid, M

AU - Musk, AW

AU - Narisu, N

AU - Nauck, M

AU - Nolte, I M

AU - Nothen, MM

AU - Oozageer, L

AU - Pilz, S

AU - Rayner, NW

AU - Renstrom, F

AU - Robertson, NR

AU - Roussel, R

AU - Sanna, S

AU - Scharnagl, H

AU - Scholtens, S

AU - Schumacher, FR

AU - Schunkert, H

AU - Sehmi, J

AU - Seufferlein, T

AU - Shi, J

AU - Silventoinen, K

AU - Smit, JH

AU - Smith, AV

AU - Smolonska, J

AU - Stanton, AV

AU - Stirrups, K

AU - Stott, DJ

AU - Stringham, HJ

AU - Sundstrom, J

AU - Swertz, MA

AU - Syvanen, AC

AU - Tayo, B O

AU - Thorleifsson, G

AU - Tyrer, JP

AU - Van Dijk, S

AU - Van Schoor, N

AU - Van Der Velde, N

AU - Van Heemst, D

AU - Van Oort, F VA

AU - Vermeulen, SH

AU - Verweij, N

AU - Vonk, JM

AU - Waite, LM

AU - Waldenberger, M

AU - Wennauer, R

AU - Wilkens, LR

AU - Willenborg, C

AU - Wilsgaard, T

AU - Wojczynski, MK

AU - Wong, A

AU - Wright, A

AU - Zhang, Q

AU - Arveiler, D

AU - Bakker, S JL

AU - Beilby, John

AU - Bergman, RN

AU - Bergmann, S

AU - Biffar, R

AU - Blangero, J

AU - Boomsma, DI

AU - Bornstein, SR

AU - Bovet, P

AU - Brambilla, P

AU - Campbell, H

AU - Caulfield, MJ

AU - Chakravarti, A

AU - Collins, R

AU - Collins, FS

AU - Crawford, Dana C.

AU - Cupples, LA

AU - Danesh, J

AU - De Faire, U

AU - Den Ruijter, HM

AU - Erbel, R

AU - Erdmann, J

AU - Eriksson, JG

AU - Farrall, M

AU - Ferrannini, E

AU - Ferrieres, J

AU - Ford, I

AU - Forouhi, NG

AU - Forrrester, T

AU - Gansevoort, RT

AU - Gejman, PV

AU - Gieger, C

AU - Golay, A

AU - Gottesman, O

AU - Gudnason, V

AU - Gyllensten, U

AU - Haas, DW

AU - Hall, AS

AU - Harris, TB

AU - Hattersley, AT

AU - Heath, AC

AU - Hengstenberg, C

AU - Hicks, AA

AU - Hindorff, LA

AU - Hingorani, AD

AU - Hofman, A

AU - Hovingh, GK

AU - Humphries, SE

AU - Hunt, SC

AU - Hypponen, A

AU - Jacobs, KB

AU - Jarvelin, MR

AU - Jousilahti, P

AU - Jula, AM

AU - Kaprio, J

AU - Kastelein, J JP

AU - Kayser, M

AU - Kee, F

AU - Keinanen-Kuikaanniemi, SM

AU - Kiemeny, LA

AU - Kooner, JS

AU - Kooperberg, C

AU - Koskinen, S

AU - Kovacs, P

AU - Kraja, AT

AU - Kumari, M

AU - Kuusisto, J

AU - Lakka, TA

AU - Langenberg, C

AU - Le Marchand, L

AU - Lehtimaki, T

AU - Lupoli, S

AU - Madden, P AF

AU - Mannisto, S

AU - Manunta, P

AU - Marette, A

AU - Matise, TC

AU - Mcknight, B

AU - Meitinger, T

AU - Moll, FL

AU - Montgomery, GW

AU - Morris, AD

AU - Morris, AP

AU - Murray, AC

AU - Nelis, M

AU - Ohlsson, C

AU - Oldehinkel, AJ

AU - Ong, KK

AU - Ouwehand, WH

AU - Pasterkamp, G

AU - Peters, A

AU - Pramstaller, PP

AU - Qi, l

AU - Raitakari, OT

AU - Rankinen, T

AU - Rao, DC

AU - Rice, TK

AU - Ritchie, M

AU - Rudan, I

AU - Salomaa, V

AU - Samani, NJ

AU - Saramies, J

AU - Sarzynski, MA

AU - Schwarz, P EH

AU - Sebert, S

AU - Sever, P

AU - Schuldiner, AR

AU - Sinisalo, J

AU - Steinthorsdittor, V

AU - Stolk, RP

AU - Tardif, J-C

AU - Tonjes, A

AU - Tremblay, A

AU - Tremoli, E

AU - Virtamo, J

AU - Vohl, M-C

AU - Amouyel, P

AU - Asselbergs, FW

AU - Assimes, TL

AU - Bochud, M

AU - Boehm, BO

AU - Boerwinkle, E

AU - Bottinger, E P

AU - Bouchard, C

AU - Cauchi, S

AU - Chambers, JC

AU - Chanock, SJ

AU - Cooper, RS

AU - De Bakker, P IW

AU - Dedoussis, G

AU - Ferrucci, L

AU - Franks, PW

AU - Frougel, P

AU - Groop, LC

AU - Haimann, CA

AU - Hamsten, A

AU - Geoffrey Hayes, M

AU - Hui, Jennie

AU - Hunter, DJ

AU - Hveem, K

AU - Jukema, J W

AU - Kaplan, RC

AU - Kivimaki, M

AU - Kuh, D

AU - Laakso, M

AU - Liu, Y

AU - Martin, NG

AU - Marz, W

AU - Melbye, M

AU - Moebus, S

AU - Munroe, PB

AU - Njolstad, I

AU - Oostra, BA

AU - Palmer, C NA

AU - Pedersen, NL

AU - Perola, M

AU - Perusse, L

AU - Peters, U

AU - Powell, JE

AU - Power, C

AU - Quatermous, T

AU - Rauramaa, R

AU - Reinmaa, E

AU - Ridker, PM

AU - Rivadeneira, F

AU - Slagboom, PE

AU - Snieder, H

AU - Spector, TD

AU - Strauch, K

AU - Stumvoll, M

AU - Tuomilehto, J

AU - Uusitupa, M

AU - Van Der Harst, P

AU - Volzke, H

AU - Walker, M

AU - Wareham, NJ

AU - Watkins, H

AU - Wichmann, H-E

AU - Wilson, JF

AU - Zanen, P

AU - Deloukas, P

AU - Heid, I M

AU - Lindgren, C M

AU - Mohlke, KL

AU - Speilotes, EK

AU - Thjorsteinsdottir, U

AU - Barroso, I

AU - Fox, C S

AU - North, K E

AU - Strachan, DP

AU - Beckman, J S

AU - Berndt, SI

AU - Boehnke, M

AU - Borecki, IB

AU - Mccarthy, M I

AU - Metspalu, A

AU - Stefansson, K

AU - Uitterlinden, A G

AU - Van Duijn, CM

AU - Franke, L

AU - Willer, CJ

AU - Price, A L

AU - Lettre, G

AU - Loos, R JF

AU - Weedon, MN

AU - O'Connell, J

AU - Abecasis, GR

AU - Chasman, DI

AU - Goddard, ME

AU - Visscher, PM

AU - Hirschhorn, JN

AU - Frayling, TM

PY - 2015

Y1 - 2015

N2 - © 2015 Macmillan Publishers Limited. All rights reserved. The main challenge for gaining biological insights from genetic associations is identifying which genes and pathways explain the associations. Here we present DEPICT, an integrative tool that employs predicted gene functions to systematically prioritize the most likely causal genes at associated loci, highlight enriched pathways and identify tissues/cell types where genes from associated loci are highly expressed. DEPICT is not limited to genes with established functions and prioritizes relevant gene sets for many phenotypes.

AB - © 2015 Macmillan Publishers Limited. All rights reserved. The main challenge for gaining biological insights from genetic associations is identifying which genes and pathways explain the associations. Here we present DEPICT, an integrative tool that employs predicted gene functions to systematically prioritize the most likely causal genes at associated loci, highlight enriched pathways and identify tissues/cell types where genes from associated loci are highly expressed. DEPICT is not limited to genes with established functions and prioritizes relevant gene sets for many phenotypes.

U2 - 10.1038/ncomms6890

DO - 10.1038/ncomms6890

M3 - Article

C2 - 25597830

SN - 2041-1723

VL - 6

SP - 1

EP - 6

JO - Nature Communications

JF - Nature Communications

ER -

Biological interpretation of genome-wide association studies using predicted gene functions

Abstract

Access to Document

Fingerprint

Cite this