Biological interpretation of genome-wide association studies using predicted gene functions

T.H. Pers, J.M. Karjalainen, Y. Chan, H.J. Westra, A.R. Wood, J. Yang, J.C. Lui, S. Vedantam, S. Gustafsson, T. Esko, T. Frayling, E.K. Speliotes, M. Boehnke, S. Raychaudhuri, R.S.N. Fehrmann, J.N. Hirschhorn, L. Franke, AR Wood, T Esko, J Yang & 438 others S Vedantam, TH Pers, S Gustafsson, AY Chu, K Estrada, J Luan, Z Kutalik, N Amin, ML Buchkovich, D C Croteau-Chonka, FR Day, Y Duan, T Fall, R Fehrmann, T Ferreira, AU Jackson, J Karjalainen, KS Lo, AE Locke, R Magi, E Mihailov, E Porcu, JC Randall, A Seherag, A AE Vinkhuyzen, HJ Westra, TW Winkler, T Workalemahu, JH Zhao, D Absher, E. Albrecht, D Anderson, J Baron, M Beekman, A Demirkan, G Ehret, B Feensta, MF Feitosa, K Fischer, RM Fraser, A Goel, J Gong, AE Justice, S Kanoni, ME Kleber, k Kristiansson, U Lim, V Lotay, JC Lui, M Mangino, IM Leach, M Medina-Gomez, MA Nalls, DR Nyholt, CD Palmer, D Pasko, S Pechlivanis, I Prokopenko, JS Reid, S Ripke, D Shungin, A Stancakova, RJ Strawbridge, YJ Sung, T Tanaka, A Tuemer, S Trompet, S Van Der Laan, J Van Setten, JV Van Vliet-Ostaptchouk, Z Wang, L Yengo, W Zhang, U Afzal, J Arnlov, GM Arscott, S Bandinelli, A Barrett, C Bellis, AJ Bennett, C Berne, M Bluher, JL Bolton, Y Bottcher, H Boyd, M Bruineberg, BM Buckley, S Buyske, IH Caspersen, PS Chines, R Clarke, S Claudi-Boehm, M Cooper, E Warwick Daw, PA De Jong, D Deelen, G Delgado, JC Denny, R Dhonukshe-Rutten, M Dimitriou, A SF Doney, M Dorr, N Eklund, E Eury, L Folkersen, M E Garcia, F Geller, V Giedraitis, A S Go, H Grallert, TB Grammer, J Grassler, H Gronberg, L C.P.G.M De Groot, CJ Groves, J Haessler, P Hall, T Haller, G Hallmans, A Hannemann, CA Hartman, M Hassinen, C Hayward, N Heard-Costa, Q Helmer, G Hemani, A K Henders, HL Hillege, MA Hlatky, W Hoffmann, P Hoffmann, O Holmen, JJ Houwing-Duistermaat, T Illig, A Isaacs, AL James, J Jeff, B Johansen, A Johannson, J Jolley, T Juliusdottir, J Junttila, AN Kho, L Kinnunen, N Klopp, T Kocher, W Kratzer, P Lichtner, L Lind, J Lindstrom, S Lobbens, M Lorentzon, Y Lu, V Lyssenko, PKE Magnusson, A Mahajan, M Maillard, W Mcardle, CA Mckenzie, S Mclachlan, PJ Mclaren, G Menni, S Merger, L Milani, A Moayyeri, KL Monda, MA Morken, G Muller, M Muller-Nurasyid, AW Musk, N Narisu, M Nauck, I M Nolte, MM Nothen, L Oozageer, S Pilz, NW Rayner, F Renstrom, NR Robertson, LM Rose, R Roussel, S Sanna, H Scharnagl, S Scholtens, FR Schumacher, H Schunkert, RA Scott, J Sehmi, T Seufferlein, J Shi, K Silventoinen, JH Smit, AV Smith, J Smolonska, AV Stanton, K Stirrups, DJ Stott, HJ Stringham, J Sundstrom, MA Swertz, AC Syvanen, B O Tayo, G Thorleifsson, JP Tyrer, S Van Dijk, N Van Schoor, N Van Der Velde, D Van Heemst, F VA Van Oort, SH Vermeulen, N Verweij, JM Vonk, LM Waite, M Waldenberger, R Wennauer, LR Wilkens, C Willenborg, T Wilsgaard, MK Wojczynski, A Wong, A Wright, Q Zhang, D Arveiler, S JL Bakker, John Beilby, RN Bergman, S Bergmann, R Biffar, J Blangero, DI Boomsma, SR Bornstein, P Bovet, P Brambilla, MJ Brown, H Campbell, MJ Caulfield, A Chakravarti, R Collins, FS Collins, Dana C. Crawford, LA Cupples, J Danesh, U De Faire, HM Den Ruijter, R Erbel, J Erdmann, JG Eriksson, M Farrall, E Ferrannini, J Ferrieres, I Ford, NG Forouhi, T Forrrester, RT Gansevoort, PV Gejman, C Gieger, A Golay, O Gottesman, V Gudnason, U Gyllensten, DW Haas, AS Hall, TB Harris, AT Hattersley, AC Heath, C Hengstenberg, AA Hicks, LA Hindorff, AD Hingorani, A Hofman, GK Hovingh, SE Humphries, SC Hunt, A Hypponen, KB Jacobs, MR Jarvelin, P Jousilahti, AM Jula, J Kaprio, J JP Kastelein, M Kayser, F Kee, SM Keinanen-Kuikaanniemi, LA Kiemeny, JS Kooner, C Kooperberg, S Koskinen, P Kovacs, AT Kraja, M Kumari, J Kuusisto, TA Lakka, C Langenberg, L Le Marchand, T Lehtimaki, S Lupoli, P AF Madden, S Mannisto, P Manunta, A Marette, TC Matise, B Mcknight, T Meitinger, FL Moll, GW Montgomery, AD Morris, AP Morris, AC Murray, M Nelis, C Ohlsson, AJ Oldehinkel, KK Ong, WH Ouwehand, G Pasterkamp, A Peters, PP Pramstaller, JF Price, l Qi, OT Raitakari, T Rankinen, DC Rao, TK Rice, M Ritchie, I Rudan, V Salomaa, NJ Samani, J Saramies, MA Sarzynski, P EH Schwarz, S Sebert, P Sever, AR Schuldiner, J Sinisalo, V Steinthorsdittor, RP Stolk, J-C Tardif, A Tonjes, A Tremblay, E Tremoli, J Virtamo, M-C Vohl, P Amouyel, FW Asselbergs, TL Assimes, M Bochud, BO Boehm, E Boerwinkle, E P Bottinger, C Bouchard, S Cauchi, JC Chambers, SJ Chanock, RS Cooper, P IW De Bakker, G Dedoussis, L Ferrucci, PW Franks, P Frougel, LC Groop, CA Haimann, A Hamsten, M Geoffrey Hayes, Jennie Hui, DJ Hunter, K Hveem, J W Jukema, RC Kaplan, M Kivimaki, D Kuh, M Laakso, Y Liu, NG Martin, W Marz, M Melbye, S Moebus, PB Munroe, I Njolstad, BA Oostra, C NA Palmer, NL Pedersen, M Perola, L Perusse, U Peters, JE Powell, C Power, T Quatermous, R Rauramaa, E Reinmaa, PM Ridker, F Rivadeneira, PE Slagboom, H Snieder, TD Spector, K Strauch, M Stumvoll, J Tuomilehto, M Uusitupa, P Van Der Harst, H Volzke, M Walker, NJ Wareham, H Watkins, H-E Wichmann, JF Wilson, P Zanen, P Deloukas, I M Heid, C M Lindgren, KL Mohlke, EK Speilotes, U Thjorsteinsdottir, I Barroso, C S Fox, K E North, DP Strachan, J S Beckman, SI Berndt, M Boehnke, IB Borecki, M I Mccarthy, A Metspalu, K Stefansson, A G Uitterlinden, CM Van Duijn, L Franke, CJ Willer, A L Price, G Lettre, R JF Loos, MN Weedon, E Ingelsson, J O'Connell, GR Abecasis, DI Chasman, ME Goddard, PM Visscher, JN Hirschhorn, TM Frayling

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Abstract

© 2015 Macmillan Publishers Limited. All rights reserved. The main challenge for gaining biological insights from genetic associations is identifying which genes and pathways explain the associations. Here we present DEPICT, an integrative tool that employs predicted gene functions to systematically prioritize the most likely causal genes at associated loci, highlight enriched pathways and identify tissues/cell types where genes from associated loci are highly expressed. DEPICT is not limited to genes with established functions and prioritizes relevant gene sets for many phenotypes.
Original languageEnglish
Pages (from-to)1-6
JournalNature Communications
Volume6
DOIs
Publication statusPublished - 2015

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Pers, T. H., Karjalainen, J. M., Chan, Y., Westra, H. J., Wood, A. R., Yang, J., ... Frayling, TM. (2015). Biological interpretation of genome-wide association studies using predicted gene functions. Nature Communications, 6, 1-6. https://doi.org/10.1038/ncomms6890