Abstract
Microbes are prolific producers of bioactive small molecules, named secondary metabolites (SMs), which have been an important source of pharmaceutical drugs and agrochemicals, as well as the cause of plant and animal diseases responsible for severe economic losses. In this thesis, I present several bioinformatic tools and pipelines for the mining of microbial genomes for biosynthetic gene clusters (BGCs) encoding novel SMs. The tools represent significant additions to the comparative genomics toolbox, improving our ability to identify and prioritise BGCs from genomic data. They also enabled an exploration into the untapped reservoir of biosynthetic diversity of Australian microbes.
Original language | English |
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Qualification | Doctor of Philosophy |
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Award date | 8 Nov 2021 |
DOIs | |
Publication status | Unpublished - 2021 |