Bioinformatics software applications for the analysis of secondary metabolism in microbial genomes

Cameron Gilchrist

Research output: ThesisDoctoral Thesis

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Abstract

Microbes are prolific producers of bioactive small molecules, named secondary metabolites (SMs), which have been an important source of pharmaceutical drugs and agrochemicals, as well as the cause of plant and animal diseases responsible for severe economic losses. In this thesis, I present several bioinformatic tools and pipelines for the mining of microbial genomes for biosynthetic gene clusters (BGCs) encoding novel SMs. The tools represent significant additions to the comparative genomics toolbox, improving our ability to identify and prioritise BGCs from genomic data. They also enabled an exploration into the untapped reservoir of biosynthetic diversity of Australian microbes.
Original languageEnglish
QualificationDoctor of Philosophy
Awarding Institution
  • The University of Western Australia
Supervisors/Advisors
  • Chooi, Heng, Supervisor
  • Mylne, Josh, Supervisor
Thesis sponsors
Award date8 Nov 2021
DOIs
Publication statusUnpublished - 2021

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