TY - JOUR
T1 - Biodistribution study of [Cu-61]pyruvaldehyde-bis (N-4-methylthiosemicarbazone) in normal rats as a PET tracer
AU - Jalilian, Amir Reza
AU - Shanesazzadeh, Saeed
AU - Rowshanfarzad, Pejaman
AU - Bolourinovin, Fatemeh
AU - Majdabad, Abbas
PY - 2008/6/20
Y1 - 2008/6/20
N2 - [Cu-61]-labeled pyruvaldehyde-bis(N-4-methylthiosemicarbazone) (Cu-61-PTSM), a promising agent made for imaging blood perfusion, was produced via the Zn-nat(p,x)Cu-61 nuclear reaction in a 30 MeV cyclotron, and separated by a two-step column chromatography method developed in our laboratory using a cation and an anion exchange resin. After 150 p-A irradiation for 76 min, about 6.006 Ci of Cu-61(2+) was obtained with a radiochemical separation yield of 95% and a radionuclidic purity of 99%. Cu-61-PTSM was prepared using an optimized method with in-house synthesized PTSM ligand for radiolabeling following quality control procedures using RTLC and HPLC. The tracer is mostly incorporated in heart, kidneys and brain compared to free copper cation as a control. These are in agreement with former reports. In conclusion, [Cu-61]-PTSM was prepared at the radiopharmaceutical scales with high quality and is a potential PET tracer in the perfusion study of the heart, kidney, brain and tumors.
AB - [Cu-61]-labeled pyruvaldehyde-bis(N-4-methylthiosemicarbazone) (Cu-61-PTSM), a promising agent made for imaging blood perfusion, was produced via the Zn-nat(p,x)Cu-61 nuclear reaction in a 30 MeV cyclotron, and separated by a two-step column chromatography method developed in our laboratory using a cation and an anion exchange resin. After 150 p-A irradiation for 76 min, about 6.006 Ci of Cu-61(2+) was obtained with a radiochemical separation yield of 95% and a radionuclidic purity of 99%. Cu-61-PTSM was prepared using an optimized method with in-house synthesized PTSM ligand for radiolabeling following quality control procedures using RTLC and HPLC. The tracer is mostly incorporated in heart, kidneys and brain compared to free copper cation as a control. These are in agreement with former reports. In conclusion, [Cu-61]-PTSM was prepared at the radiopharmaceutical scales with high quality and is a potential PET tracer in the perfusion study of the heart, kidney, brain and tumors.
KW - copper-61
KW - PTSM
KW - biodistribution
KW - radiolabeling
KW - BIS N-4-METHYLTHIOSEMICARBAZONE
KW - BLOOD-FLOW
KW - CU-PTSM
KW - COPPER
KW - COMPLEX
KW - CU-61
KW - TARGET
UR - http://www.scopus.com/inward/record.url?scp=47949084275&partnerID=8YFLogxK
U2 - 10.1016/S1001-8042(08)60043-3
DO - 10.1016/S1001-8042(08)60043-3
M3 - Article
VL - 19
SP - 159
EP - 164
JO - Nuclear science and techniques
JF - Nuclear science and techniques
SN - 1001-8042
IS - 3
ER -