Biodistribution of [64Cu]pyruvaldehyde-bis (N 4-methylthiosemicarbazone) complex in fibrosarcoma-bearing rats

Amir Reza Jalilian, Pezhman Rowshanfarzad, Mohsen Kamali-Dehghan, Kamaladin Shafaei, Mohammad Mirzaei, Gholamreza Aslani

Research output: Contribution to journalArticle

Abstract

Introduction: 64Cu-pyruvaldehyde-bis(N4- methylthiosemicarbazone) (64Cu-PTSM) is one of the most important copper radiopharmaceuticals used in clinical experiments. Methods: In this work, copper-64 (T1/2=12.33 h) production has been presented followed by the synthesis of the complexing agent, PTSM, and its structure was confirmed by common spectroscopic methods followed by radiolabeling with 64Cu- actetate. The tracer was finally administered to fibrosarcoma-bearing rats and the biodistribution was determined in critical tissues as well as tumor. Results: The final radiopharmaceutical solution underwent common quality control tests for animal injection a radiochemical purity >95% was determined. A significant tracer tumor uptake was observed 2 hours post injection. Tumor:muscle and tumor:blood ratios were shown to be 8 and 6 respectively. Conclusion: 64Cu-PTSM prepared in this report is a good candidate for tumor therapy as well as diagnosis for national use.

Original languageEnglish
JournalIranian Journal of Nuclear Medicine
Volume15
Issue number27
Publication statusPublished - 31 Jul 2007

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