TY - JOUR
T1 - Biocompatible hyperbranched polyglycerol modified β-cyclodextrin derivatives for docetaxel delivery
AU - Xu, Zejun
AU - Zhang, Yi
AU - Hu, Qian
AU - Tang, Qiao
AU - Xu, Jiake
AU - Wu, Jianping
AU - Kirk, Thomas Brett
AU - Ma, Dong
AU - Xue, Wei
PY - 2017/2/1
Y1 - 2017/2/1
N2 - The development of biocompatible vector for hydrophobic drug delivery remains a longstanding issue in cancer therapy. We design and synthesis a drug delivery system based on HPG modified β-CD (β-CD-HPG) by conjugating HPG branches onto β-CD core and its structure was confirmed by NMR, FTIR, GPC and solubility. In vitro biocompatibility tests showed that HPG modification significantly improved red blood cells morphology alteration and hemolysis cause by β-CD and β-CD-HPG displayed cell safety apparently in a wide range of 0.01–1 mg/mL. An anti-cancer drug, docetaxel, was effectively encapsulated into β-CD-HPG which was confirmed by DSC analysis. This copolymer could form nanoparticles with small size (< 200 nm) and exhibited better DTX loading capacity and controlled release kinetics without initial burst release behavior compared with β-CD. Furthermore, antitumor assay in vitro show that β-CD-HPG/DTX effectively inhibited proliferation of human breast adenocarcinoma cells. Therefore, β-CD-HPG/DTX exhibit great potential for cancer chemotherapy.
AB - The development of biocompatible vector for hydrophobic drug delivery remains a longstanding issue in cancer therapy. We design and synthesis a drug delivery system based on HPG modified β-CD (β-CD-HPG) by conjugating HPG branches onto β-CD core and its structure was confirmed by NMR, FTIR, GPC and solubility. In vitro biocompatibility tests showed that HPG modification significantly improved red blood cells morphology alteration and hemolysis cause by β-CD and β-CD-HPG displayed cell safety apparently in a wide range of 0.01–1 mg/mL. An anti-cancer drug, docetaxel, was effectively encapsulated into β-CD-HPG which was confirmed by DSC analysis. This copolymer could form nanoparticles with small size (< 200 nm) and exhibited better DTX loading capacity and controlled release kinetics without initial burst release behavior compared with β-CD. Furthermore, antitumor assay in vitro show that β-CD-HPG/DTX effectively inhibited proliferation of human breast adenocarcinoma cells. Therefore, β-CD-HPG/DTX exhibit great potential for cancer chemotherapy.
KW - Biocompatibility
KW - Cancer therapy
KW - Drug carrier
KW - Hyperbranched polyglycerol (HPG)
KW - β-Cyclodextrin (β-CD)
UR - http://www.scopus.com/inward/record.url?scp=85006237280&partnerID=8YFLogxK
U2 - 10.1016/j.msec.2016.11.005
DO - 10.1016/j.msec.2016.11.005
M3 - Article
C2 - 27987795
AN - SCOPUS:85006237280
SN - 0928-4931
VL - 71
SP - 965
EP - 972
JO - Materials Science and Engineering C
JF - Materials Science and Engineering C
ER -
