Biochemical changes within a multiple sclerosis plaque in vivo

TAD CADOUXHUDSON, A KERMODE, B RAJAGOPALAN, D TAYLOR, AJ THOMPSON, IEC ORMEROD, WI MCDONALD, GK RADDA

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Abstract

Magnetic resonance spectroscopy (MRS) was performed on a superficial part of the brain containing a large multiple sclerosis (MS) lesion. Reduced levels of phosphocreatine (PCr) relative to adenosine triphosphate (ATP) were found suggesting an abnormality in energy metabolism, with an increase in the phosphodiester (PDE) peak. A follow up study 16 months later revealed reduction in size of the lesion on MRI and normal intracellular biochemistry by MRS. Four MS patients without visible superficial cerebral lesions showed no significant changes in phosphorus metabolism.

Original languageEnglish
Pages (from-to)1004-1006
Number of pages3
JournalJournal of Neurology Neurosurgery and Psychiatry
Volume54
Issue number11
DOIs
Publication statusPublished - Nov 1991
Externally publishedYes

Cite this

CADOUXHUDSON, TAD., KERMODE, A., RAJAGOPALAN, B., TAYLOR, D., THOMPSON, AJ., ORMEROD, IEC., ... RADDA, GK. (1991). Biochemical changes within a multiple sclerosis plaque in vivo. Journal of Neurology Neurosurgery and Psychiatry, 54(11), 1004-1006. https://doi.org/10.1136/jnnp.54.11.1004