TY - JOUR
T1 - Bioactive lipids in cancer stem cells
AU - Begicevic, Romana Rea
AU - Arfuso, Frank
AU - Falasca, Marco
N1 - Funding Information:
The authors acknowledge the infrastructure and staff support provided by the School of Pharmacy and Biomedical Sciences and CHIRI, Faculty of Health Sciences Curtin University. This Project is made possible by an Avner Pancreatic Cancer Foundation Grant (www.avnersfoundation.org.au). RRB is supported by the “Australian Government Research Training Program Scholarship”.
Funding Information:
Supported by Avner Pancreatic
Funding Information:
The authors acknowledge the infrastructure and staff support provided by the School of Pharmacy and Biomedical Sciences and CHIRI, Faculty of Health Sciences Curtin University. This Project is made possible by an Avner Pancreatic Cancer Foundation Grant (www.avnersfoundation.org.au). RRB is supported by the "Australian Government Research Training Program Scholarship".
Publisher Copyright:
© 2019 Baishideng Publishing Group Inc.
PY - 2019/9/1
Y1 - 2019/9/1
N2 - Tumours are known to be a heterogeneous group of cells, which is why they are difficult to eradicate. One possible cause for this is the existence of slow-cycling cancer stem cells (CSCs) endowed with stem cell-like properties of self-renewal, which are responsible for resistance to chemotherapy and radiotherapy. In recent years, the role of lipid metabolism has garnered increasing attention in cancer. Specifically, the key roles of enzymes such as stearoyl-CoA desaturase-1 and 3- hydroxy-3-methyl-glutaryl-coenzyme A reductase in CSCs, have gained particular interest. However, despite accumulating evidence on the role of proteins in controlling lipid metabolism, very little is known about the specific role played by lipid products in CSCs. This review highlights recent findings on the role of lipid metabolism in CSCs, focusing on the specific mechanism by which bioactive lipids regulate the fate of CSCs and their involvement in signal transduction pathways.
AB - Tumours are known to be a heterogeneous group of cells, which is why they are difficult to eradicate. One possible cause for this is the existence of slow-cycling cancer stem cells (CSCs) endowed with stem cell-like properties of self-renewal, which are responsible for resistance to chemotherapy and radiotherapy. In recent years, the role of lipid metabolism has garnered increasing attention in cancer. Specifically, the key roles of enzymes such as stearoyl-CoA desaturase-1 and 3- hydroxy-3-methyl-glutaryl-coenzyme A reductase in CSCs, have gained particular interest. However, despite accumulating evidence on the role of proteins in controlling lipid metabolism, very little is known about the specific role played by lipid products in CSCs. This review highlights recent findings on the role of lipid metabolism in CSCs, focusing on the specific mechanism by which bioactive lipids regulate the fate of CSCs and their involvement in signal transduction pathways.
KW - ABC transporters
KW - Bioactive lipids
KW - Cancer stem cells
KW - Lipid metabolism
UR - http://www.scopus.com/inward/record.url?scp=85072780905&partnerID=8YFLogxK
U2 - 10.4252/wjsc.v11.i9.693
DO - 10.4252/wjsc.v11.i9.693
M3 - Review article
AN - SCOPUS:85072780905
SN - 1948-0210
VL - 11
SP - 693
EP - 704
JO - World Journal of Stem Cells
JF - World Journal of Stem Cells
IS - 9
ER -
