Binge-eating disorder in the Swedish national registers: Somatic comorbidity

Laura M. Thornton, Hunna J. Watson, Andreas Jangmo, Elisabeth Welch, Camilla Wiklund, Yvonne von Hausswolff-Juhlin, Claes Norring, Barry K. Herman, Henrik Larsson, Cynthia M. Bulik

    Research output: Contribution to journalArticle

    16 Citations (Scopus)

    Abstract

    Objective: To evaluate associations between binge-eating disorder (BED) and somatic illnesses and determine whether medical comorbidities are more common in individuals who present with BED and comorbid obesity. Method: Cases (n = 850) were individuals with a BED diagnosis in the Swedish eating disorders quality registers. Ten community controls were matched to each case on sex, and year, month, and county of birth. Associations of BED status with neurologic, immune, respiratory, gastrointestinal, skin, musculoskeletal, genitourinary, circulatory, and endocrine system diseases were evaluated using conditional logistic regression models. We further examined these associations by adjusting for lifetime psychiatric comorbidity. Amongst individuals with BED, we explored whether comorbid obesity was associated with risk of somatic disorders. Results: BED was associated with most classes of diseases evaluated; strongest associations were with diabetes [odds ratio (95% confidence interval) = 5.7 (3.8; 8.7)] and circulatory systems [1.9 (1.3; 2.7)], likely indexing components of metabolic syndrome. Amongst individuals with BED, those with comorbid obesity were more likely to have a lifetime history of respiratory [1.5 (1.1; 2.1)] and gastrointestinal [2.6 (1.7; 4.1)] diseases than those without comorbid obesity. Increased risk of some somatic disease classes in individuals with BED was not simply due to obesity or other lifetime psychiatric comorbidity. Discussion: The association of BED with many somatic illnesses highlights the morbidity experienced by individuals with BED. Clinicians treating patients with BED should be vigilant for medical comorbidities. Nonpsychiatric providers may be the first clinical contact for those with BED underscoring the importance of screening in primary care.

    Original languageEnglish
    Pages (from-to)58-65
    Number of pages8
    JournalInternational Journal of Eating Disorders
    Volume50
    Issue number1
    DOIs
    Publication statusPublished - 1 Jan 2017

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    Binge-Eating Disorder
    Comorbidity
    Obesity
    Cardiovascular System
    Psychiatry
    Logistic Models
    Urogenital System
    Endocrine System Diseases
    Musculoskeletal System
    Nervous System

    Cite this

    Thornton, L. M., Watson, H. J., Jangmo, A., Welch, E., Wiklund, C., von Hausswolff-Juhlin, Y., ... Bulik, C. M. (2017). Binge-eating disorder in the Swedish national registers: Somatic comorbidity. International Journal of Eating Disorders, 50(1), 58-65. https://doi.org/10.1002/eat.22624
    Thornton, Laura M. ; Watson, Hunna J. ; Jangmo, Andreas ; Welch, Elisabeth ; Wiklund, Camilla ; von Hausswolff-Juhlin, Yvonne ; Norring, Claes ; Herman, Barry K. ; Larsson, Henrik ; Bulik, Cynthia M. / Binge-eating disorder in the Swedish national registers : Somatic comorbidity. In: International Journal of Eating Disorders. 2017 ; Vol. 50, No. 1. pp. 58-65.
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    title = "Binge-eating disorder in the Swedish national registers: Somatic comorbidity",
    abstract = "Objective: To evaluate associations between binge-eating disorder (BED) and somatic illnesses and determine whether medical comorbidities are more common in individuals who present with BED and comorbid obesity. Method: Cases (n = 850) were individuals with a BED diagnosis in the Swedish eating disorders quality registers. Ten community controls were matched to each case on sex, and year, month, and county of birth. Associations of BED status with neurologic, immune, respiratory, gastrointestinal, skin, musculoskeletal, genitourinary, circulatory, and endocrine system diseases were evaluated using conditional logistic regression models. We further examined these associations by adjusting for lifetime psychiatric comorbidity. Amongst individuals with BED, we explored whether comorbid obesity was associated with risk of somatic disorders. Results: BED was associated with most classes of diseases evaluated; strongest associations were with diabetes [odds ratio (95{\%} confidence interval) = 5.7 (3.8; 8.7)] and circulatory systems [1.9 (1.3; 2.7)], likely indexing components of metabolic syndrome. Amongst individuals with BED, those with comorbid obesity were more likely to have a lifetime history of respiratory [1.5 (1.1; 2.1)] and gastrointestinal [2.6 (1.7; 4.1)] diseases than those without comorbid obesity. Increased risk of some somatic disease classes in individuals with BED was not simply due to obesity or other lifetime psychiatric comorbidity. Discussion: The association of BED with many somatic illnesses highlights the morbidity experienced by individuals with BED. Clinicians treating patients with BED should be vigilant for medical comorbidities. Nonpsychiatric providers may be the first clinical contact for those with BED underscoring the importance of screening in primary care.",
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    author = "Thornton, {Laura M.} and Watson, {Hunna J.} and Andreas Jangmo and Elisabeth Welch and Camilla Wiklund and {von Hausswolff-Juhlin}, Yvonne and Claes Norring and Herman, {Barry K.} and Henrik Larsson and Bulik, {Cynthia M.}",
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    Thornton, LM, Watson, HJ, Jangmo, A, Welch, E, Wiklund, C, von Hausswolff-Juhlin, Y, Norring, C, Herman, BK, Larsson, H & Bulik, CM 2017, 'Binge-eating disorder in the Swedish national registers: Somatic comorbidity' International Journal of Eating Disorders, vol. 50, no. 1, pp. 58-65. https://doi.org/10.1002/eat.22624

    Binge-eating disorder in the Swedish national registers : Somatic comorbidity. / Thornton, Laura M.; Watson, Hunna J.; Jangmo, Andreas; Welch, Elisabeth; Wiklund, Camilla; von Hausswolff-Juhlin, Yvonne; Norring, Claes; Herman, Barry K.; Larsson, Henrik; Bulik, Cynthia M.

    In: International Journal of Eating Disorders, Vol. 50, No. 1, 01.01.2017, p. 58-65.

    Research output: Contribution to journalArticle

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    T2 - Somatic comorbidity

    AU - Thornton, Laura M.

    AU - Watson, Hunna J.

    AU - Jangmo, Andreas

    AU - Welch, Elisabeth

    AU - Wiklund, Camilla

    AU - von Hausswolff-Juhlin, Yvonne

    AU - Norring, Claes

    AU - Herman, Barry K.

    AU - Larsson, Henrik

    AU - Bulik, Cynthia M.

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    N2 - Objective: To evaluate associations between binge-eating disorder (BED) and somatic illnesses and determine whether medical comorbidities are more common in individuals who present with BED and comorbid obesity. Method: Cases (n = 850) were individuals with a BED diagnosis in the Swedish eating disorders quality registers. Ten community controls were matched to each case on sex, and year, month, and county of birth. Associations of BED status with neurologic, immune, respiratory, gastrointestinal, skin, musculoskeletal, genitourinary, circulatory, and endocrine system diseases were evaluated using conditional logistic regression models. We further examined these associations by adjusting for lifetime psychiatric comorbidity. Amongst individuals with BED, we explored whether comorbid obesity was associated with risk of somatic disorders. Results: BED was associated with most classes of diseases evaluated; strongest associations were with diabetes [odds ratio (95% confidence interval) = 5.7 (3.8; 8.7)] and circulatory systems [1.9 (1.3; 2.7)], likely indexing components of metabolic syndrome. Amongst individuals with BED, those with comorbid obesity were more likely to have a lifetime history of respiratory [1.5 (1.1; 2.1)] and gastrointestinal [2.6 (1.7; 4.1)] diseases than those without comorbid obesity. Increased risk of some somatic disease classes in individuals with BED was not simply due to obesity or other lifetime psychiatric comorbidity. Discussion: The association of BED with many somatic illnesses highlights the morbidity experienced by individuals with BED. Clinicians treating patients with BED should be vigilant for medical comorbidities. Nonpsychiatric providers may be the first clinical contact for those with BED underscoring the importance of screening in primary care.

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