Bilateral coats reaction in Bannayan-Zonana syndrome: a single case report

Meredith R. Klifto, Chandrakumar Balaratnasingam, Harold H. Weissman, Lawrence A. Yannuzzi

Research output: Contribution to journalArticlepeer-review

2 Citations (Scopus)


Purpose: To report the clinical features of bilateral Coats reaction in a patient with Bannayan-Zonana syndrome. Methods: The clinical course and retinal manifestations of a 21-year-old patient with Bannayan-Zonana syndrome and bilateral Coats reaction were studied. Retinal manifestations were documented with clinical examination, ultrawide-field color imaging, and ultrawide-field fluorescein angiography. Results: Best-corrected visual acuities were 20/25 OD and 20/25 OS. Anterior segment examinations were normal bilaterally. The inferotemporal quadrant of the left retina demonstrated retinal telangiectasias, exudation, and a neurosensory retinal detachment extending to the mid-periphery. Fluorescein angiography demonstrated bilateral peripheral nonperfusion and vascular staining. An epiretinal membrane also involved the left macula. Conclusion: Bannayan-Zonana syndrome is an autosomal-dominant, hamartomatous disease characterized by a mutation spectrum that involves genes responsible for vascular development. Retinal vascular abnormalities and exudation can be a manifestation of this syndrome.

Original languageEnglish
Pages (from-to)286-289
Number of pages4
JournalRetinal Cases and Brief Reports
Issue number3
Publication statusPublished - 1 Jun 2017


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