Bi-exponential proton transverse relaxation rate (R2) image analysis using RF field intensity-weighted spin density projection: potential for R2 measurement of iron-loaded liver

P.R. Clark, Wanida Chua-Anusorn, Tim St Pierre

    Research output: Contribution to journalArticle

    42 Citations (Scopus)

    Abstract

    A bi-exponential proton transverse relaxation rate (R2) image analysis technique has been developed that enables the discrimination of dual compartment transverse relaxation behavior in systems with rapid transverse relaxation enhancement. The technique is particularly well suited to single spin-echo imaging studies where a limited number of images are available for analysis. The bi-exponential R2 image analysis is facilitated by estimation of the initial proton spin density signal within the region of interest weighted by the RF field intensities. The RF field intensity-weighted spin density map is computed by solving a boundary value problem presented by a high spin density, long T2 material encompassing the region for analysis. The accuracy of the bi-exponential R2 image analysis technique is demonstrated on a simulated dual compartment manganese chloride phantom system with relaxation rates and relative population densities between the two compartments similar to the bi-exponential transverse relaxation behavior expected of iron loaded liver. Results from analysis of the phantoms illustrate the potential of bi-exponential R2 image analysis with RF field intensity-weighted spin density projection for quantifying transverse relaxation enhancement as it occurs in liver iron overload.
    Original languageEnglish
    Pages (from-to)519-530
    JournalMagnetic Resonance Imaging
    Volume21
    Issue number5
    DOIs
    Publication statusPublished - 2003

    Fingerprint Dive into the research topics of 'Bi-exponential proton transverse relaxation rate (R2) image analysis using RF field intensity-weighted spin density projection: potential for R2 measurement of iron-loaded liver'. Together they form a unique fingerprint.

  • Cite this