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Abstract
With the impending ‘retirement’ of bronchial thermoplasty (BT) for the treatment of patients with asthma, there is much to learn from this real-world experiment that will help us develop more effective future therapies with the same primary target i.e., airway smooth muscle (ASM) remodelling. This viewpoint discusses initial controversy surrounding BT (lack of an effect on forced expiratory volume in 1 s), its underutilisation, and importantly how non-standard diagnostics successfully demonstrated therapeutic response which escaped traditional lung function metrics. It is anticipated that the next iteration of BT (likely in a drug form) will have an overall greater effect on the health care system by virtue of evoking ASM remodelling as a treatable trait, and after appropriately drawing on lessons learned from the ∼fifteen-year BT saga.
Original language | English |
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Article number | 103017 |
Number of pages | 4 |
Journal | EClinicalMedicine |
Volume | 79 |
DOIs | |
Publication status | Published - Jan 2025 |
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Unravelling a clinical paradox: why does bronchial thermoplasty work in asthma and how can we improve patient outcomes?
Noble, P. (Investigator 01), Langton, D. (Investigator 02), Donovan, G. (Investigator 03), Cense, B. (Investigator 04), Thien, F. (Investigator 05), Thompson, B. (Investigator 06), Mulrennan, S. (Investigator 07) & Rosenow, T. (Investigator 08)
NHMRC National Health and Medical Research Council
1/01/20 → 31/12/25
Project: Research