Beyond Averages: Sleep Intraindividual Variability and its Relation to Cognitive Function and Brain Beta-Amyloid Burden in Community-Dwelling Older Adults

Alex Mladenovic

Research output: ThesisDoctoral Thesis

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Abstract

Sleep intraindividual variability (S-IIV), the variability in sleep from night to night, is an emerging aspect of suboptimal sleep that yields additional information not obtainable by solely examining habitual, mean sleep. Preliminary evidence suggests that greater S-IIV is associated with cognitive ageing. The results from this thesis showed that older adults with greater S-IIV evidenced poorer episodic memory performance and higher levels of brain beta-amyloid pathology. While these findings indicate that greater S-IIV may increase the risk of cognitive decline, with implications for cognitive preservation through improving and regularising sleep, further research is needed to clarify the direction of causation.
Original languageEnglish
QualificationDoctor of Philosophy
Awarding Institution
  • The University of Western Australia
Supervisors/Advisors
  • Weinborn, Michael, Supervisor
  • Bucks, Romola, Supervisor
  • Rainey-Smith, Stephanie, Supervisor
Thesis sponsors
Award date6 Jun 2023
DOIs
Publication statusUnpublished - 2023

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