Beyond Averages: Sleep Intraindividual Variability and its Relation to Cognitive Function and Brain Beta-Amyloid Burden in Community-Dwelling Older Adults

Alex Mladenovic

doi:10.26182/497y-h248

Beyond Averages: Sleep Intraindividual Variability and its Relation to Cognitive Function and Brain Beta-Amyloid Burden in Community-Dwelling Older Adults

Alex Mladenovic

Research output: Thesis › Doctoral Thesis

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Abstract

Sleep intraindividual variability (S-IIV), the variability in sleep from night to night, is an emerging aspect of suboptimal sleep that yields additional information not obtainable by solely examining habitual, mean sleep. Preliminary evidence suggests that greater S-IIV is associated with cognitive ageing. The results from this thesis showed that older adults with greater S-IIV evidenced poorer episodic memory performance and higher levels of brain beta-amyloid pathology. While these findings indicate that greater S-IIV may increase the risk of cognitive decline, with implications for cognitive preservation through improving and regularising sleep, further research is needed to clarify the direction of causation.

Original language	English
Qualification	Doctor of Philosophy
Awarding Institution	The University of Western Australia
Supervisors/Advisors	Weinborn, Michael, Supervisor Bucks, Romola, Supervisor Rainey-Smith, Stephanie, Supervisor
Thesis sponsors	Australian Government Research Training Program
Award date	6 Jun 2023
DOIs	https://doi.org/10.26182/497y-h248
Publication status	Unpublished - 2023

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10.26182/497y-h248

THESIS - DOCTOR OF PHILOSOPHY AND MASTER OF CLINICAL NEUROPSYCHOLOGY - MLADENOVIC Alex - 2023
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Cite this

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AB - Sleep intraindividual variability (S-IIV), the variability in sleep from night to night, is an emerging aspect of suboptimal sleep that yields additional information not obtainable by solely examining habitual, mean sleep. Preliminary evidence suggests that greater S-IIV is associated with cognitive ageing. The results from this thesis showed that older adults with greater S-IIV evidenced poorer episodic memory performance and higher levels of brain beta-amyloid pathology. While these findings indicate that greater S-IIV may increase the risk of cognitive decline, with implications for cognitive preservation through improving and regularising sleep, further research is needed to clarify the direction of causation.

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Beyond Averages: Sleep Intraindividual Variability and its Relation to Cognitive Function and Brain Beta-Amyloid Burden in Community-Dwelling Older Adults

Abstract

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