Betamethasone for lung maturation: testing dose and formulation in fetal sheep

A.H. Jobe, T.J. Moss, Ilias Nitsos, M. Ikegami, S.G. Kallapur, John Newnham

    Research output: Contribution to journalArticle

    19 Citations (Scopus)

    Abstract

    Objective: We evaluated lung maturation responses to the mixture of betamethasone phosphate (Beta-PO4) + betamethasone acetate (Beta-Ac) in comparison to Beta-PO4 or Beta-Ac in fetal sheep.Study design: Ewes carrying singleton pregnancies at 122 days of gestation were randomized to single doses of 0.5 mg/kg Beta-PO4 + Beta-Ac, 0.25 mg/kg Beta-PO4, 0.5 mg/kg Beta-PO4, or 0.25 mg/kg Beta-Ac given 48 hours before delivery. These treatments were compared with saline placebo and 2 doses of 0.5 mg/kg Beta-PO4 + Beta-Ac that were given 48 and 24 hours before delivery. Fetal lung maturation was evaluated.Results: The 2 doses of the Beta-PO4 = Beta-Ac mixture gave the best lung maturation. Single doses of the Beta-PO4 = Beta-Ac mixture and Beta-Ac alone also induced lung maturation. There were no consistent responses to either dose of Beta-PO4.Conclusion: Beta-PO4 alone is ineffective with the dosing schedule used; Beta-Ac can induce lung maturation. However, the best responses result from the mixture of Beta-PO4 + Beta-Ac.
    Original languageEnglish
    Pages (from-to)523.e1-523.e6
    JournalAmerican Journal of Obstetrics & Gynecology
    Volume197
    Issue number5
    DOIs
    Publication statusPublished - 2007

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