Beta2 adrenergic receptor (ADRβ2) haplotype pair (2/4) is associated with severe asthma

L. Chung, Svetlana Baltic, M.A.R. Ferreira, Suzanna Temple, Grant Waterer, Philip Thompson

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Abstract

Background: β2 adrenergic receptor (ADRβ2) polymorphisms including ADRβ2+46G.A have been reported to cause adverse outcomes in mild asthmatics. The extent to which ADRb2 polymorphisms and in particular their haplotypes contribute to severe asthma is unknown. Objective: To determine the association of ADRb2 polymorphisms and haplotypes with asthma severity. Methods: Caucasians (n = 2979) were genotyped for 11 ADRβ2 polymorphisms. The cohort (mean age 39.6, 60% female) included 2296 non-asthmatics, 386 mild asthmatics, 172 moderate asthmatics and 125 severe asthmatics. Haplotype frequency and haplotype pair for each subject was determined using the PHASE algorithm. Results: The three asthmatic cohorts were comparable in age and gender but were distinguishable from each other in terms of symptoms, spirometry, medication use and health care utilisation (p
Original languageEnglish
Pages (from-to)12pp
JournalPLoS One
Volume9
Issue number4
DOIs
Publication statusPublished - 2014

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