Bathyptilones: Terpenoids from an Antarctic Sea Pen, Anthoptilum grandiflorum (Verrill, 1879)

Santana A.L. Thomas, Anthony Sanchez, Younghoon Kee, Nerida G. Wilson, Bill J. Baker

Research output: Contribution to journalArticlepeer-review

7 Citations (Web of Science)


© 2019 by the authors. An Antarctic coral belonging to the order Pennatulacea, collected during the 2013 austral autumn by trawl from 662 to 944 m depth, has yielded three new briarane diterpenes, bathyptilone A-C (1–3) along with a trinorditerpene, enbepeanone A (4), which bears a new carbon skeleton. Structure elucidation was facilitated by one- and two-dimensional NMR spectroscopy, mass spectrometry and confirmed by X-ray crystallography. The three compounds were screened in four cancer cell lines. Bathyptilone A displayed selective nanomolar cytotoxicity against the neurogenic mammalian cell line Ntera-2.
Original languageEnglish
Article number513
Number of pages13
JournalMarine Drugs
Issue number9
Publication statusPublished - 1 Sept 2019


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