Bathyptilones: Terpenoids from an Antarctic Sea Pen, Anthoptilum grandiflorum (Verrill, 1879)

Santana A.L. Thomas; Anthony Sanchez; Younghoon Kee; Nerida G. Wilson; Bill J. Baker

doi:10.3390/md17090513

Bathyptilones: Terpenoids from an Antarctic Sea Pen, Anthoptilum grandiflorum (Verrill, 1879)

Santana A.L. Thomas, Anthony Sanchez, Younghoon Kee, Nerida G. Wilson, Bill J. Baker

School of Biological Sciences

Research output: Contribution to journal › Article › peer-review

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Abstract

© 2019 by the authors. An Antarctic coral belonging to the order Pennatulacea, collected during the 2013 austral autumn by trawl from 662 to 944 m depth, has yielded three new briarane diterpenes, bathyptilone A-C (1–3) along with a trinorditerpene, enbepeanone A (4), which bears a new carbon skeleton. Structure elucidation was facilitated by one- and two-dimensional NMR spectroscopy, mass spectrometry and confirmed by X-ray crystallography. The three compounds were screened in four cancer cell lines. Bathyptilone A displayed selective nanomolar cytotoxicity against the neurogenic mammalian cell line Ntera-2.

Original language	English
Article number	513
Number of pages	13
Journal	Marine Drugs
Volume	17
Issue number	9
DOIs	https://doi.org/10.3390/md17090513
Publication status	Published - 1 Sept 2019

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title = "Bathyptilones: Terpenoids from an Antarctic Sea Pen, Anthoptilum grandiflorum (Verrill, 1879)",

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T1 - Bathyptilones: Terpenoids from an Antarctic Sea Pen, Anthoptilum grandiflorum (Verrill, 1879)

AU - Thomas, Santana A.L.

AU - Sanchez, Anthony

AU - Kee, Younghoon

AU - Wilson, Nerida G.

AU - Baker, Bill J.

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AB - © 2019 by the authors. An Antarctic coral belonging to the order Pennatulacea, collected during the 2013 austral autumn by trawl from 662 to 944 m depth, has yielded three new briarane diterpenes, bathyptilone A-C (1–3) along with a trinorditerpene, enbepeanone A (4), which bears a new carbon skeleton. Structure elucidation was facilitated by one- and two-dimensional NMR spectroscopy, mass spectrometry and confirmed by X-ray crystallography. The three compounds were screened in four cancer cell lines. Bathyptilone A displayed selective nanomolar cytotoxicity against the neurogenic mammalian cell line Ntera-2.

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Bathyptilones: Terpenoids from an Antarctic Sea Pen, Anthoptilum grandiflorum (Verrill, 1879)

Abstract

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