Bathyptilones: Terpenoids from an Antarctic Sea Pen, Anthoptilum grandiflorum (Verrill, 1879)

Santana A.L. Thomas, Anthony Sanchez, Younghoon Kee, Nerida G. Wilson, Bill J. Baker

Research output: Contribution to journalArticle

Abstract

© 2019 by the authors. An Antarctic coral belonging to the order Pennatulacea, collected during the 2013 austral autumn by trawl from 662 to 944 m depth, has yielded three new briarane diterpenes, bathyptilone A-C (1–3) along with a trinorditerpene, enbepeanone A (4), which bears a new carbon skeleton. Structure elucidation was facilitated by one- and two-dimensional NMR spectroscopy, mass spectrometry and confirmed by X-ray crystallography. The three compounds were screened in four cancer cell lines. Bathyptilone A displayed selective nanomolar cytotoxicity against the neurogenic mammalian cell line Ntera-2.
Original languageEnglish
Article number513
Number of pages13
JournalMarine Drugs
Volume17
Issue number9
DOIs
Publication statusPublished - 1 Sep 2019

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Terpenes
Oceans and Seas
Cell Line
Anthozoa
Diterpenes
X Ray Crystallography
Skeleton
Mass Spectrometry
Magnetic Resonance Spectroscopy
Carbon
Neoplasms

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Thomas, Santana A.L. ; Sanchez, Anthony ; Kee, Younghoon ; Wilson, Nerida G. ; Baker, Bill J. / Bathyptilones: Terpenoids from an Antarctic Sea Pen, Anthoptilum grandiflorum (Verrill, 1879). In: Marine Drugs. 2019 ; Vol. 17, No. 9.
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Bathyptilones: Terpenoids from an Antarctic Sea Pen, Anthoptilum grandiflorum (Verrill, 1879). / Thomas, Santana A.L.; Sanchez, Anthony; Kee, Younghoon; Wilson, Nerida G.; Baker, Bill J.

In: Marine Drugs, Vol. 17, No. 9, 513, 01.09.2019.

Research output: Contribution to journalArticle

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