@article{2aa0198a2c14438fba32ab94b4ea92c9,
title = "Basic Biology of Extracellular Matrix in the Cardiovascular System, Part 1/4: JACC Focus Seminar",
abstract = "The extracellular matrix (ECM) is the noncellular component of tissues in the cardiovascular system and other organs throughout the body. It is formed of filamentous proteins, proteoglycans, and glycosaminoglycans, which extensively interact and whose structure and dynamics are modified by cross-linking, bridging proteins, and cleavage by matrix degrading enzymes. The ECM serves important structural and regulatory roles in establishing tissue architecture and cellular function. The ECM of the developing heart has unique properties created by its emerging contractile nature; similarly, ECM lining blood vessels is highly elastic in order to sustain the basal and pulsatile forces imposed on their walls throughout life. In this part 1 of a 4-part JACC Focus Seminar, we focus on the role, function, and basic biology of the ECM in both heart development and in the adult.",
keywords = "cardiovascular, collagen, development, homeostasis, matrix",
author = "{del Monte-Nieto}, Gonzalo and Fischer, {Jens W.} and Gorski, {Daniel J.} and Harvey, {Richard P.} and Kovacic, {Jason C.}",
note = "Funding Information: Dr. del Monte-Nieto has received research support from the Heart Foundation of Australia (grant FLF1-102036), the Australian Research Council (grant DP190101475), and the Australian Regenerative Medicine Institute, which is supported by grants from the State Government of Victoria and the Australian Government. Dr. Fischer acknowledges research support from the German Research Foundation (grants SFB1116, IRTG1902, and TRR259). Dr. Harvey has received support from the National Health and Medical Research Council of Australia (grants 1074386, 573732, 573705, and 1118576), the Australian Research Council (grants DP190101475 and DP160104858), the New South Wales Government Ministry of Health (20:20 Campaign, Cardiovascular Disease Senior Scientist Grant). Dr. Kovacic has received research support from the National Institutes of Health (grants R01HL130423 and R01HL135093). Dr. Gorski has reported that he has no relationships relevant to the contents of this paper to disclose. Thomas Wight, MD, served as Guest Editor for this paper. Funding Information: Dr. del Monte-Nieto has received research support from the Heart Foundation of Australia (grant FLF1-102036), the Australian Research Council (grant DP190101475), and the Australian Regenerative Medicine Institute, which is supported by grants from the State Government of Victoria and the Australian Government. Dr. Fischer acknowledges research support from the German Research Foundation (grants SFB1116, IRTG1902, and TRR259). Dr. Harvey has received support from the National Health and Medical Research Council of Australia (grants 1074386, 573732, 573705, and 1118576), the Australian Research Council (grants DP190101475 and DP160104858), the New South Wales Government Ministry of Health (20:20 Campaign, Cardiovascular Disease Senior Scientist Grant). Dr. Kovacic has received research support from the National Institutes of Health (grants R01HL130423 and R01HL135093). Dr. Gorski has reported that he has no relationships relevant to the contents of this paper to disclose. Thomas Wight, MD, served as Guest Editor for this paper. Publisher Copyright: {\textcopyright} 2020 American College of Cardiology Foundation",
year = "2020",
month = may,
day = "5",
doi = "10.1016/j.jacc.2020.03.024",
language = "English",
volume = "75",
pages = "2169--2188",
journal = "Journal of the American College of Cardiology",
issn = "0735-1097",
publisher = "Academic Press",
number = "17",
}