Baseline grey matter volume of non-transitioned "ultra high risk" for psychosis individuals with and without attenuated psychotic symptoms at long-term follow-up

V.L. Cropley, Ashleigh Lin, B. Nelson, R.L.E.P. Reniers, A.R. Yung, C.F. Bartholomeusz, P. Klauser, D. Velakoulis, P. Mcgorry, S.J. Wood, C. Pantelis

Research output: Contribution to journalArticle

10 Citations (Scopus)
154 Downloads (Pure)

Abstract

© 2015 Elsevier B.V. Introduction: Two thirds of individuals identified as ultra-high risk (UHR) for psychosis do not transition to psychosis over the medium to long-term (non-transition; UHR-NT). Nevertheless, many of these individuals have persistent attenuated psychotic symptoms (APS). The current study examined whether there were differences in baseline grey matter volume (i.e. at initial identification as UHR) in UHR-NT individuals whom had APS compared to those without APS (No-APS) at medium to long-term follow-up. Methods: Participants were help-seeking individuals who were identified as being at UHR for psychosis between 2 and 12 years previously (mean = 7.5). The sample consisted of 109 participants who underwent a Magnetic Resonance Imaging scan at baseline and who had not been observed to develop a psychotic disorder over the follow-up period (UHR-NT). Using voxel-based morphometry, baseline grey matter volume (GMV) was compared between participants with (N = 30) and without (N = 79) APS at follow-up. Results: At baseline, the APS and No-APS groups were clinically indistinguishable. At follow-up, the APS group had significantly worse symptoms and impaired functioning. Individuals with APS had reduced baseline GMV in frontal, temporal, posterior and cingulate regions compared to those without APS at follow-up. Reduced GMV was associated with more severe positive, negative and depressive symptoms and lower global functioning in the combined UHR-NT cohort. These associations were independent of later APS outcome. Discussion: This study found that differences in regional GMV are discernible at an early stage of UHR and may be specific to individuals who have APS and psychopathology at follow-up. Our findings suggest that lower GMV at baseline may confer neurobiological risk for later APS and/or increased psychopathology while the absence of these structural abnormalities might be protective.
Original languageEnglish
Pages (from-to)152-158
JournalSchizophrenia Research
Volume173
Issue number3
Early online date29 May 2015
DOIs
Publication statusPublished - Jun 2016

Fingerprint

Psychotic Disorders
Psychopathology
Gray Matter
Gyrus Cinguli
Temporal Lobe
Magnetic Resonance Imaging
Depression

Cite this

Cropley, V.L. ; Lin, Ashleigh ; Nelson, B. ; Reniers, R.L.E.P. ; Yung, A.R. ; Bartholomeusz, C.F. ; Klauser, P. ; Velakoulis, D. ; Mcgorry, P. ; Wood, S.J. ; Pantelis, C. / Baseline grey matter volume of non-transitioned "ultra high risk" for psychosis individuals with and without attenuated psychotic symptoms at long-term follow-up. In: Schizophrenia Research. 2016 ; Vol. 173, No. 3. pp. 152-158.
@article{3611e90ece174ec5a9e643247e2ac043,
title = "Baseline grey matter volume of non-transitioned {"}ultra high risk{"} for psychosis individuals with and without attenuated psychotic symptoms at long-term follow-up",
abstract = "{\circledC} 2015 Elsevier B.V. Introduction: Two thirds of individuals identified as ultra-high risk (UHR) for psychosis do not transition to psychosis over the medium to long-term (non-transition; UHR-NT). Nevertheless, many of these individuals have persistent attenuated psychotic symptoms (APS). The current study examined whether there were differences in baseline grey matter volume (i.e. at initial identification as UHR) in UHR-NT individuals whom had APS compared to those without APS (No-APS) at medium to long-term follow-up. Methods: Participants were help-seeking individuals who were identified as being at UHR for psychosis between 2 and 12 years previously (mean = 7.5). The sample consisted of 109 participants who underwent a Magnetic Resonance Imaging scan at baseline and who had not been observed to develop a psychotic disorder over the follow-up period (UHR-NT). Using voxel-based morphometry, baseline grey matter volume (GMV) was compared between participants with (N = 30) and without (N = 79) APS at follow-up. Results: At baseline, the APS and No-APS groups were clinically indistinguishable. At follow-up, the APS group had significantly worse symptoms and impaired functioning. Individuals with APS had reduced baseline GMV in frontal, temporal, posterior and cingulate regions compared to those without APS at follow-up. Reduced GMV was associated with more severe positive, negative and depressive symptoms and lower global functioning in the combined UHR-NT cohort. These associations were independent of later APS outcome. Discussion: This study found that differences in regional GMV are discernible at an early stage of UHR and may be specific to individuals who have APS and psychopathology at follow-up. Our findings suggest that lower GMV at baseline may confer neurobiological risk for later APS and/or increased psychopathology while the absence of these structural abnormalities might be protective.",
author = "V.L. Cropley and Ashleigh Lin and B. Nelson and R.L.E.P. Reniers and A.R. Yung and C.F. Bartholomeusz and P. Klauser and D. Velakoulis and P. Mcgorry and S.J. Wood and C. Pantelis",
year = "2016",
month = "6",
doi = "10.1016/j.schres.2015.05.014",
language = "English",
volume = "173",
pages = "152--158",
journal = "Schizophrenia Research",
issn = "0920-9964",
publisher = "Pergamon",
number = "3",

}

Cropley, VL, Lin, A, Nelson, B, Reniers, RLEP, Yung, AR, Bartholomeusz, CF, Klauser, P, Velakoulis, D, Mcgorry, P, Wood, SJ & Pantelis, C 2016, 'Baseline grey matter volume of non-transitioned "ultra high risk" for psychosis individuals with and without attenuated psychotic symptoms at long-term follow-up' Schizophrenia Research, vol. 173, no. 3, pp. 152-158. https://doi.org/10.1016/j.schres.2015.05.014

Baseline grey matter volume of non-transitioned "ultra high risk" for psychosis individuals with and without attenuated psychotic symptoms at long-term follow-up. / Cropley, V.L.; Lin, Ashleigh; Nelson, B.; Reniers, R.L.E.P.; Yung, A.R.; Bartholomeusz, C.F.; Klauser, P.; Velakoulis, D.; Mcgorry, P.; Wood, S.J.; Pantelis, C.

In: Schizophrenia Research, Vol. 173, No. 3, 06.2016, p. 152-158.

Research output: Contribution to journalArticle

TY - JOUR

T1 - Baseline grey matter volume of non-transitioned "ultra high risk" for psychosis individuals with and without attenuated psychotic symptoms at long-term follow-up

AU - Cropley, V.L.

AU - Lin, Ashleigh

AU - Nelson, B.

AU - Reniers, R.L.E.P.

AU - Yung, A.R.

AU - Bartholomeusz, C.F.

AU - Klauser, P.

AU - Velakoulis, D.

AU - Mcgorry, P.

AU - Wood, S.J.

AU - Pantelis, C.

PY - 2016/6

Y1 - 2016/6

N2 - © 2015 Elsevier B.V. Introduction: Two thirds of individuals identified as ultra-high risk (UHR) for psychosis do not transition to psychosis over the medium to long-term (non-transition; UHR-NT). Nevertheless, many of these individuals have persistent attenuated psychotic symptoms (APS). The current study examined whether there were differences in baseline grey matter volume (i.e. at initial identification as UHR) in UHR-NT individuals whom had APS compared to those without APS (No-APS) at medium to long-term follow-up. Methods: Participants were help-seeking individuals who were identified as being at UHR for psychosis between 2 and 12 years previously (mean = 7.5). The sample consisted of 109 participants who underwent a Magnetic Resonance Imaging scan at baseline and who had not been observed to develop a psychotic disorder over the follow-up period (UHR-NT). Using voxel-based morphometry, baseline grey matter volume (GMV) was compared between participants with (N = 30) and without (N = 79) APS at follow-up. Results: At baseline, the APS and No-APS groups were clinically indistinguishable. At follow-up, the APS group had significantly worse symptoms and impaired functioning. Individuals with APS had reduced baseline GMV in frontal, temporal, posterior and cingulate regions compared to those without APS at follow-up. Reduced GMV was associated with more severe positive, negative and depressive symptoms and lower global functioning in the combined UHR-NT cohort. These associations were independent of later APS outcome. Discussion: This study found that differences in regional GMV are discernible at an early stage of UHR and may be specific to individuals who have APS and psychopathology at follow-up. Our findings suggest that lower GMV at baseline may confer neurobiological risk for later APS and/or increased psychopathology while the absence of these structural abnormalities might be protective.

AB - © 2015 Elsevier B.V. Introduction: Two thirds of individuals identified as ultra-high risk (UHR) for psychosis do not transition to psychosis over the medium to long-term (non-transition; UHR-NT). Nevertheless, many of these individuals have persistent attenuated psychotic symptoms (APS). The current study examined whether there were differences in baseline grey matter volume (i.e. at initial identification as UHR) in UHR-NT individuals whom had APS compared to those without APS (No-APS) at medium to long-term follow-up. Methods: Participants were help-seeking individuals who were identified as being at UHR for psychosis between 2 and 12 years previously (mean = 7.5). The sample consisted of 109 participants who underwent a Magnetic Resonance Imaging scan at baseline and who had not been observed to develop a psychotic disorder over the follow-up period (UHR-NT). Using voxel-based morphometry, baseline grey matter volume (GMV) was compared between participants with (N = 30) and without (N = 79) APS at follow-up. Results: At baseline, the APS and No-APS groups were clinically indistinguishable. At follow-up, the APS group had significantly worse symptoms and impaired functioning. Individuals with APS had reduced baseline GMV in frontal, temporal, posterior and cingulate regions compared to those without APS at follow-up. Reduced GMV was associated with more severe positive, negative and depressive symptoms and lower global functioning in the combined UHR-NT cohort. These associations were independent of later APS outcome. Discussion: This study found that differences in regional GMV are discernible at an early stage of UHR and may be specific to individuals who have APS and psychopathology at follow-up. Our findings suggest that lower GMV at baseline may confer neurobiological risk for later APS and/or increased psychopathology while the absence of these structural abnormalities might be protective.

U2 - 10.1016/j.schres.2015.05.014

DO - 10.1016/j.schres.2015.05.014

M3 - Article

VL - 173

SP - 152

EP - 158

JO - Schizophrenia Research

JF - Schizophrenia Research

SN - 0920-9964

IS - 3

ER -