Baseline and Post-treatment 18F-Fluorocholine PET/CT Predicts Outcomes in Hepatocellular Carcinoma Following Locoregional Therapy

Michael C. Wallace, Kenny Sek, Roslyn J. Francis, Shaun Samuelson, John Ferguson, Jonathan Tibballs, Ali Asad, David B. Preen, Gerry MacQuillan, George Garas, Leon A. Adams, Gary P. Jeffrey

Research output: Contribution to journalArticle

Abstract

Background and Aims: 18F-fluorocholine positron emission tomography/computed tomography (18F-FCH PET/CT) is an emerging functional imaging technique in the diagnosis and management of hepatocellular carcinoma (HCC). The aim of this study was to assess the ability of a pre- and post-treatment 18F-FCH PET/CT to predict prognosis and treatment response in early-stage HCC. Methods: Patients with early- or intermediate-stage HCC planned for locoregional therapy were prospectively enrolled. Baseline demographic and tumor information was collected and baseline and post-treatment 18F-FCH PET/CT performed. Maximum standardized uptake values (SUVmax) were determined for each HCC lesion, and the difference between baseline and post-treatment SUVmax values were compared with progression-free survival outcomes. Results: A total of 29 patients with 39 confirmed HCC lesions were enrolled from a single clinical center. Patients were mostly men (89.7%) with hepatitis C or alcohol-related cirrhosis (65.5%) and early-stage disease (89.7%). Per-patient and per-lesion sensitivity of 18F-FCH PET/CT was 72.4% and 59.0%, respectively. A baseline SUVmax < 13 was associated with a superior median progression-free survival compared with an SUVmax of > 13 (17.7 vs. 5.1 months; p = 0.006). A > 45% decrease in SUVmax between baseline and post-treatment 18F-FCH PET/CT (“responders”) was associated with a superior mean progression-free survival than a percentage decrease of < 45% (“non-responders,” 36.1 vs. 11.6 months; p = 0.034). Conclusions: Baseline and post-treatment 18F-FCH PET/CT predicts outcomes in early-stage HCC undergoing locoregional therapy. This technique may identify patients with an objective response post-locoregional therapy who would benefit from further therapy.

Original languageEnglish
Pages (from-to)647-657
JournalDigestive Diseases and Sciences
Volume65
Issue number2
DOIs
Publication statusPublished - Feb 2020

Fingerprint Dive into the research topics of 'Baseline and Post-treatment 18F-Fluorocholine PET/CT Predicts Outcomes in Hepatocellular Carcinoma Following Locoregional Therapy'. Together they form a unique fingerprint.

Cite this