Barium titanate nanoparticles for biomarker applications

O. Matar, O.M. Posada, N.S. Hondow, C. Wälti, Martin Saunders, C.A. Murray, R.M.D. Brydson, S.J. Milne, A.P. Brown

Research output: Chapter in Book/Conference paperConference paperpeer-review

11 Citations (Scopus)


A tetragonal crystal structure is required for barium titanate nanoparticles to exhibit the nonlinear optical effect of second harmonic light generation (SHG) for use as a biomarker when illuminated by a near-infrared source. Here we use synchrotron XRD to elucidate the tetragonal phase of commercially purchased tetragonal, cubic and hydrothermally prepared barium titanate (BaTiO3) nanoparticles by peak fitting with reference patterns. The local phase of individual nanoparticles is determined by STEM electron energy loss spectroscopy (EELS), measuring the core-loss O K-edge and the Ti L3-edge energy separation of the t2g, eg peaks. The results show a change in energy separation between the t2g and eg peak from the surface and core of the particles, suggesting an intraparticle phase mixture of the barium titanate nanoparticles. HAADF-STEM and bright field TEM-EDX show cellular uptake of the hydrothermally prepared BaTiO3 nanoparticles, highlighting the potential for application as biomarkers.
Original languageEnglish
Title of host publicationJournal of Physics: Conference Series
Place of PublicationENGLAND
PublisherIOP Publishing
ISBN (Print)17426588
Publication statusPublished - 2015
EventBarium titanate nanoparticles for biomarker applications - Manchester, UK
Duration: 1 Jan 2015 → …


ConferenceBarium titanate nanoparticles for biomarker applications
Period1/01/15 → …


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