BADASP: Predicting functional specificity in protein families using ancestral sequences

Richard J. Edwards, Denis C. Shields

Research output: Contribution to journalArticlepeer-review

21 Citations (Scopus)


Summary: Burst After Duplication with Ancestral Sequence Predictions (BADASP) is a software package for identifying sites that may confer subfamily-specific biological functions in protein families following functional divergence of duplicated proteins. A given protein phylogeny is grouped into subfamilies based on orthology/paralogy relationships and/or user definitions. Ancestral sequences are then predicted from the sequence alignment and the functional specificity is calculated using variants of the Burst After Duplication method, which tests for radical amino acid substitutions following gene duplications that are subsequently conserved. Statistics are output along with subfamily groupings and ancestral sequences for an easy analysis with other packages.

Original languageEnglish
Pages (from-to)4190-4191
Number of pages2
Issue number22
Publication statusPublished - 15 Nov 2005
Externally publishedYes


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