Bacteriology and clinical outcomes of patients with culture-positive pleural infection in Western Australia: A 6-year analysis

Fraser Brims, Natalia Popowicz, Andrew Rosenstengel, Julie Hart, Arthee Yogendran, Catherine A. Read, Felicity Lee, Ranjan Shrestha, Alexander Franke, Joshua R. Lewis, Ian Kay, Grant Waterer, Y. C.Gary Lee

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3 Citations (Scopus)

Abstract

Background and objective: Pleural infection is a clinical challenge; its microbiology can be complex. Epidemiological and outcome data of pleural infection in adult Australians are lacking. We describe the bacteriology and clinical outcomes of Australian adults with culture-positive pleural infection (CPPI) over a 6-year period. Methods: Cases with CPPI were identified through Western Australian public hospitals electronic record. Culture isolates, admission dates, vital status, co-morbidities, radiology, blood and pleural fluid tests were extracted. Results: In total, 601 cases (71.4% males; median age: 63 years (IQR: 50–74); median hospital stay 13 days) involving 894 bacterial isolates were identified. Hospital-acquired (HA)-CPPI was defined in 398 (66.2%) cases, community-acquired (CA)-CPPI in 164 (27.3%) cases and the remaining classified as oesophageal rupture/leak. Co-morbidities, most frequently cancer, were common (65.2%). Radiological evidence of pneumonia was present in only 43.8% of CA-CPPI and 27.3% of HA-CPPI. Of the 153 different bacterial strains cultured, Streptococcus species (32.9%) especially viridans streptococci group were most common in CA-CPPI, whereas HA-CPPI was most often associated with Staphylococcus aureus (11.6%) and Gram-negative (31.9%) infections. Mortality was high during hospitalization (CA-CPPI 13.4% vs HA-CPPI 16.6%; P = 0.417) and at 1 year (CA-CPPI 32.4% vs HA-CPPI 45.5%; P = 0.006). Conclusion: This is the first large multicentre epidemiological study of pleural infection in Australian adults and includes the largest cohort of HA-CPPI published to date. CPPI is caused by a diverse range of organisms which vary between CA and HA sources. CPPI is a poor prognostic indicator both in the short term and in the subsequent 12 months.

Original languageEnglish
Pages (from-to)171-178
Number of pages8
JournalRespirology
Volume24
Issue number2
Early online date6 Sep 2018
DOIs
Publication statusPublished - Feb 2019

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Western Australia
Bacteriology
Infection
Cross Infection
Viridans Streptococci
Morbidity
Hospital Records
Public Hospitals
Community Hospital

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Brims, Fraser ; Popowicz, Natalia ; Rosenstengel, Andrew ; Hart, Julie ; Yogendran, Arthee ; Read, Catherine A. ; Lee, Felicity ; Shrestha, Ranjan ; Franke, Alexander ; Lewis, Joshua R. ; Kay, Ian ; Waterer, Grant ; Lee, Y. C.Gary. / Bacteriology and clinical outcomes of patients with culture-positive pleural infection in Western Australia : A 6-year analysis. In: Respirology. 2019 ; Vol. 24, No. 2. pp. 171-178.
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title = "Bacteriology and clinical outcomes of patients with culture-positive pleural infection in Western Australia: A 6-year analysis",
abstract = "Background and objective: Pleural infection is a clinical challenge; its microbiology can be complex. Epidemiological and outcome data of pleural infection in adult Australians are lacking. We describe the bacteriology and clinical outcomes of Australian adults with culture-positive pleural infection (CPPI) over a 6-year period. Methods: Cases with CPPI were identified through Western Australian public hospitals electronic record. Culture isolates, admission dates, vital status, co-morbidities, radiology, blood and pleural fluid tests were extracted. Results: In total, 601 cases (71.4{\%} males; median age: 63 years (IQR: 50–74); median hospital stay 13 days) involving 894 bacterial isolates were identified. Hospital-acquired (HA)-CPPI was defined in 398 (66.2{\%}) cases, community-acquired (CA)-CPPI in 164 (27.3{\%}) cases and the remaining classified as oesophageal rupture/leak. Co-morbidities, most frequently cancer, were common (65.2{\%}). Radiological evidence of pneumonia was present in only 43.8{\%} of CA-CPPI and 27.3{\%} of HA-CPPI. Of the 153 different bacterial strains cultured, Streptococcus species (32.9{\%}) especially viridans streptococci group were most common in CA-CPPI, whereas HA-CPPI was most often associated with Staphylococcus aureus (11.6{\%}) and Gram-negative (31.9{\%}) infections. Mortality was high during hospitalization (CA-CPPI 13.4{\%} vs HA-CPPI 16.6{\%}; P = 0.417) and at 1 year (CA-CPPI 32.4{\%} vs HA-CPPI 45.5{\%}; P = 0.006). Conclusion: This is the first large multicentre epidemiological study of pleural infection in Australian adults and includes the largest cohort of HA-CPPI published to date. CPPI is caused by a diverse range of organisms which vary between CA and HA sources. CPPI is a poor prognostic indicator both in the short term and in the subsequent 12 months.",
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author = "Fraser Brims and Natalia Popowicz and Andrew Rosenstengel and Julie Hart and Arthee Yogendran and Read, {Catherine A.} and Felicity Lee and Ranjan Shrestha and Alexander Franke and Lewis, {Joshua R.} and Ian Kay and Grant Waterer and Lee, {Y. C.Gary}",
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Bacteriology and clinical outcomes of patients with culture-positive pleural infection in Western Australia : A 6-year analysis. / Brims, Fraser; Popowicz, Natalia; Rosenstengel, Andrew; Hart, Julie; Yogendran, Arthee; Read, Catherine A.; Lee, Felicity; Shrestha, Ranjan; Franke, Alexander; Lewis, Joshua R.; Kay, Ian; Waterer, Grant; Lee, Y. C.Gary.

In: Respirology, Vol. 24, No. 2, 02.2019, p. 171-178.

Research output: Contribution to journalArticle

TY - JOUR

T1 - Bacteriology and clinical outcomes of patients with culture-positive pleural infection in Western Australia

T2 - A 6-year analysis

AU - Brims, Fraser

AU - Popowicz, Natalia

AU - Rosenstengel, Andrew

AU - Hart, Julie

AU - Yogendran, Arthee

AU - Read, Catherine A.

AU - Lee, Felicity

AU - Shrestha, Ranjan

AU - Franke, Alexander

AU - Lewis, Joshua R.

AU - Kay, Ian

AU - Waterer, Grant

AU - Lee, Y. C.Gary

PY - 2019/2

Y1 - 2019/2

N2 - Background and objective: Pleural infection is a clinical challenge; its microbiology can be complex. Epidemiological and outcome data of pleural infection in adult Australians are lacking. We describe the bacteriology and clinical outcomes of Australian adults with culture-positive pleural infection (CPPI) over a 6-year period. Methods: Cases with CPPI were identified through Western Australian public hospitals electronic record. Culture isolates, admission dates, vital status, co-morbidities, radiology, blood and pleural fluid tests were extracted. Results: In total, 601 cases (71.4% males; median age: 63 years (IQR: 50–74); median hospital stay 13 days) involving 894 bacterial isolates were identified. Hospital-acquired (HA)-CPPI was defined in 398 (66.2%) cases, community-acquired (CA)-CPPI in 164 (27.3%) cases and the remaining classified as oesophageal rupture/leak. Co-morbidities, most frequently cancer, were common (65.2%). Radiological evidence of pneumonia was present in only 43.8% of CA-CPPI and 27.3% of HA-CPPI. Of the 153 different bacterial strains cultured, Streptococcus species (32.9%) especially viridans streptococci group were most common in CA-CPPI, whereas HA-CPPI was most often associated with Staphylococcus aureus (11.6%) and Gram-negative (31.9%) infections. Mortality was high during hospitalization (CA-CPPI 13.4% vs HA-CPPI 16.6%; P = 0.417) and at 1 year (CA-CPPI 32.4% vs HA-CPPI 45.5%; P = 0.006). Conclusion: This is the first large multicentre epidemiological study of pleural infection in Australian adults and includes the largest cohort of HA-CPPI published to date. CPPI is caused by a diverse range of organisms which vary between CA and HA sources. CPPI is a poor prognostic indicator both in the short term and in the subsequent 12 months.

AB - Background and objective: Pleural infection is a clinical challenge; its microbiology can be complex. Epidemiological and outcome data of pleural infection in adult Australians are lacking. We describe the bacteriology and clinical outcomes of Australian adults with culture-positive pleural infection (CPPI) over a 6-year period. Methods: Cases with CPPI were identified through Western Australian public hospitals electronic record. Culture isolates, admission dates, vital status, co-morbidities, radiology, blood and pleural fluid tests were extracted. Results: In total, 601 cases (71.4% males; median age: 63 years (IQR: 50–74); median hospital stay 13 days) involving 894 bacterial isolates were identified. Hospital-acquired (HA)-CPPI was defined in 398 (66.2%) cases, community-acquired (CA)-CPPI in 164 (27.3%) cases and the remaining classified as oesophageal rupture/leak. Co-morbidities, most frequently cancer, were common (65.2%). Radiological evidence of pneumonia was present in only 43.8% of CA-CPPI and 27.3% of HA-CPPI. Of the 153 different bacterial strains cultured, Streptococcus species (32.9%) especially viridans streptococci group were most common in CA-CPPI, whereas HA-CPPI was most often associated with Staphylococcus aureus (11.6%) and Gram-negative (31.9%) infections. Mortality was high during hospitalization (CA-CPPI 13.4% vs HA-CPPI 16.6%; P = 0.417) and at 1 year (CA-CPPI 32.4% vs HA-CPPI 45.5%; P = 0.006). Conclusion: This is the first large multicentre epidemiological study of pleural infection in Australian adults and includes the largest cohort of HA-CPPI published to date. CPPI is caused by a diverse range of organisms which vary between CA and HA sources. CPPI is a poor prognostic indicator both in the short term and in the subsequent 12 months.

KW - bacteria

KW - empyema, pleural

KW - survival

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DO - 10.1111/resp.13395

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