Azathioprine therapy in a case of pediatric multiple sclerosis that was seropositive for MOG-IgG

Yifan Zhou; Qiao Huang; Tingting Lu; Xiaobo Sun; Ling Fang; Zhengqi Lu; Xueqiang Hu; Allan Kermode; Wei Qiu

doi:10.1016/j.jocn.2016.12.022

Azathioprine therapy in a case of pediatric multiple sclerosis that was seropositive for MOG-IgG

Yifan Zhou, Qiao Huang, Tingting Lu, Xiaobo Sun, Ling Fang, Zhengqi Lu, Xueqiang Hu, Allan Kermode, Wei Qiu

Centre for Neuromuscular & Neurological Disorders

Research output: Contribution to journal › Article

4 Citations (Scopus)

Abstract

There is a lack of evidence for treatment of pediatric multiple sclerosis (PedMS). Treatment using azathioprine for PedMS has not been reported. A 10-year-old boy with multiple sclerosis who was seropositive for antibodies against myelin oligodendrocyte glycoprotein (MOG)-IgG was treated with azathioprine plus oral methylprednisolone. The patient showed clinical and magnetic resonance imaging stability, with MOG-IgG seroconversion. There were no major side effects over a 5-year period. Azathioprine may be a treatment option, particularly in poor medical resource areas, for pediatric patients with multiple sclerosis who are seropositive for MOG-IgG.

Original language	English
Pages (from-to)	71-73
Number of pages	3
Journal	Journal of Clinical Neuroscience
Volume	38
DOIs	https://doi.org/10.1016/j.jocn.2016.12.022
Publication status	Published - 1 Apr 2017

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title = "Azathioprine therapy in a case of pediatric multiple sclerosis that was seropositive for MOG-IgG",

abstract = "There is a lack of evidence for treatment of pediatric multiple sclerosis (PedMS). Treatment using azathioprine for PedMS has not been reported. A 10-year-old boy with multiple sclerosis who was seropositive for antibodies against myelin oligodendrocyte glycoprotein (MOG)-IgG was treated with azathioprine plus oral methylprednisolone. The patient showed clinical and magnetic resonance imaging stability, with MOG-IgG seroconversion. There were no major side effects over a 5-year period. Azathioprine may be a treatment option, particularly in poor medical resource areas, for pediatric patients with multiple sclerosis who are seropositive for MOG-IgG.",

keywords = "Azathioprine, MOG-IgG, Multiple sclerosis, Pediatric",

author = "Yifan Zhou and Qiao Huang and Tingting Lu and Xiaobo Sun and Ling Fang and Zhengqi Lu and Xueqiang Hu and Allan Kermode and Wei Qiu",

year = "2017",

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T1 - Azathioprine therapy in a case of pediatric multiple sclerosis that was seropositive for MOG-IgG

AU - Zhou, Yifan

AU - Huang, Qiao

AU - Lu, Tingting

AU - Sun, Xiaobo

AU - Fang, Ling

AU - Lu, Zhengqi

AU - Hu, Xueqiang

AU - Kermode, Allan

AU - Qiu, Wei

PY - 2017/4/1

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N2 - There is a lack of evidence for treatment of pediatric multiple sclerosis (PedMS). Treatment using azathioprine for PedMS has not been reported. A 10-year-old boy with multiple sclerosis who was seropositive for antibodies against myelin oligodendrocyte glycoprotein (MOG)-IgG was treated with azathioprine plus oral methylprednisolone. The patient showed clinical and magnetic resonance imaging stability, with MOG-IgG seroconversion. There were no major side effects over a 5-year period. Azathioprine may be a treatment option, particularly in poor medical resource areas, for pediatric patients with multiple sclerosis who are seropositive for MOG-IgG.

AB - There is a lack of evidence for treatment of pediatric multiple sclerosis (PedMS). Treatment using azathioprine for PedMS has not been reported. A 10-year-old boy with multiple sclerosis who was seropositive for antibodies against myelin oligodendrocyte glycoprotein (MOG)-IgG was treated with azathioprine plus oral methylprednisolone. The patient showed clinical and magnetic resonance imaging stability, with MOG-IgG seroconversion. There were no major side effects over a 5-year period. Azathioprine may be a treatment option, particularly in poor medical resource areas, for pediatric patients with multiple sclerosis who are seropositive for MOG-IgG.

KW - Azathioprine

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