Axial length variation impacts on retinal vessel density and foveal avascular zone area measurement using optical coherence tomography angiography

Danuta M. Sampson; Peijun Gong; Di An; Moreno Menghini; Alex Hansen; David A. Mackey; David D. Sampson; Fred K. Chen

doi:10.1117/12.2270134

Axial length variation impacts on retinal vessel density and foveal avascular zone area measurement using optical coherence tomography angiography

Danuta M. Sampson, Peijun Gong, Di An, Moreno Menghini, Alex Hansen, David A. Mackey, David D. Sampson, Fred K. Chen

Research output: Chapter in Book/Conference paper › Conference paper › peer-review

1 Citation (Scopus)

Abstract

We examined the impact of axial length on superficial retinal vessel density (SRVD) and foveal avascular zone area (FAZA) measurement using optical coherence tomography angiography. The SRVD and FAZA were quantified before and after correction for magnification error associated with axial length variation. Although SRVD did not differ before and after correction for magnification error in the parafoveal region, change in foveal SRVD and FAZA were significant. This has implications for clinical trials outcome in diseased eyes where significant capillary dropout may occur in the parafovea.

Original language	English
Title of host publication	International Conference on Biophotonics V
Editors	Jurgen Popp, Brian C. Wilson, David D. Sampson, Dennis L. Matthews, Halina Rubinsztein-Dunlop
Publisher	SPIE-SOC PHOTO-OPTICAL INSTRUMENTATION ENGINEERS
Number of pages	1
ISBN (Electronic)	9781510611252
DOIs	https://doi.org/10.1117/12.2270134
Publication status	Published - 29 Apr 2017
Event	5th International Conference on Biophotonics, ICOB 2017 - Perth, Australia Duration: 30 Apr 2017 → 1 May 2017

Publication series

Name	Progress in Biomedical Optics and Imaging - Proceedings of SPIE
Volume	10340
ISSN (Print)	1605-7422

Conference

Conference	5th International Conference on Biophotonics, ICOB 2017
Country/Territory	Australia
City	Perth
Period	30/04/17 → 1/05/17

Access to Document

10.1117/12.2270134

Cite this

Sampson, D. M., Gong, P., An, D., Menghini, M., Hansen, A., Mackey, D. A., Sampson, D. D., & Chen, F. K. (2017). Axial length variation impacts on retinal vessel density and foveal avascular zone area measurement using optical coherence tomography angiography. In J. Popp, B. C. Wilson, D. D. Sampson, D. L. Matthews, & H. Rubinsztein-Dunlop (Eds.), International Conference on Biophotonics V Article 1034017 (Progress in Biomedical Optics and Imaging - Proceedings of SPIE; Vol. 10340). SPIE-SOC PHOTO-OPTICAL INSTRUMENTATION ENGINEERS. https://doi.org/10.1117/12.2270134

Sampson, Danuta M. ; Gong, Peijun ; An, Di et al. / Axial length variation impacts on retinal vessel density and foveal avascular zone area measurement using optical coherence tomography angiography. International Conference on Biophotonics V. editor / Jurgen Popp ; Brian C. Wilson ; David D. Sampson ; Dennis L. Matthews ; Halina Rubinsztein-Dunlop. SPIE-SOC PHOTO-OPTICAL INSTRUMENTATION ENGINEERS, 2017. (Progress in Biomedical Optics and Imaging - Proceedings of SPIE).

@inproceedings{d98487a5ecfa461ababbc78eeefa7965,

title = "Axial length variation impacts on retinal vessel density and foveal avascular zone area measurement using optical coherence tomography angiography",

abstract = "We examined the impact of axial length on superficial retinal vessel density (SRVD) and foveal avascular zone area (FAZA) measurement using optical coherence tomography angiography. The SRVD and FAZA were quantified before and after correction for magnification error associated with axial length variation. Although SRVD did not differ before and after correction for magnification error in the parafoveal region, change in foveal SRVD and FAZA were significant. This has implications for clinical trials outcome in diseased eyes where significant capillary dropout may occur in the parafovea.",

author = "Sampson, {Danuta M.} and Peijun Gong and Di An and Moreno Menghini and Alex Hansen and Mackey, {David A.} and Sampson, {David D.} and Chen, {Fred K.}",

note = "Publisher Copyright: {\textcopyright} 2017 SPIE.; 5th International Conference on Biophotonics, ICOB 2017 ; Conference date: 30-04-2017 Through 01-05-2017",

year = "2017",

month = apr,

day = "29",

doi = "10.1117/12.2270134",

language = "English",

series = "Progress in Biomedical Optics and Imaging - Proceedings of SPIE",

publisher = "SPIE-SOC PHOTO-OPTICAL INSTRUMENTATION ENGINEERS",

editor = "Jurgen Popp and Wilson, {Brian C.} and Sampson, {David D.} and Matthews, {Dennis L.} and Halina Rubinsztein-Dunlop",

booktitle = "International Conference on Biophotonics V",

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Sampson, DM , Gong, P, An, D, Menghini, M, Hansen, A, Mackey, DA, Sampson, DD & Chen, FK 2017, Axial length variation impacts on retinal vessel density and foveal avascular zone area measurement using optical coherence tomography angiography. in J Popp, BC Wilson, DD Sampson, DL Matthews & H Rubinsztein-Dunlop (eds), International Conference on Biophotonics V., 1034017, Progress in Biomedical Optics and Imaging - Proceedings of SPIE, vol. 10340, SPIE-SOC PHOTO-OPTICAL INSTRUMENTATION ENGINEERS, 5th International Conference on Biophotonics, ICOB 2017, Perth, Western Australia, Australia, 30/04/17. https://doi.org/10.1117/12.2270134

Axial length variation impacts on retinal vessel density and foveal avascular zone area measurement using optical coherence tomography angiography. / Sampson, Danuta M.; Gong, Peijun; An, Di et al.
International Conference on Biophotonics V. ed. / Jurgen Popp; Brian C. Wilson; David D. Sampson; Dennis L. Matthews; Halina Rubinsztein-Dunlop. SPIE-SOC PHOTO-OPTICAL INSTRUMENTATION ENGINEERS, 2017. 1034017 (Progress in Biomedical Optics and Imaging - Proceedings of SPIE; Vol. 10340).

Research output: Chapter in Book/Conference paper › Conference paper › peer-review

TY - GEN

T1 - Axial length variation impacts on retinal vessel density and foveal avascular zone area measurement using optical coherence tomography angiography

AU - Sampson, Danuta M.

AU - Gong, Peijun

AU - An, Di

AU - Menghini, Moreno

AU - Hansen, Alex

AU - Mackey, David A.

AU - Sampson, David D.

AU - Chen, Fred K.

PY - 2017/4/29

Y1 - 2017/4/29

N2 - We examined the impact of axial length on superficial retinal vessel density (SRVD) and foveal avascular zone area (FAZA) measurement using optical coherence tomography angiography. The SRVD and FAZA were quantified before and after correction for magnification error associated with axial length variation. Although SRVD did not differ before and after correction for magnification error in the parafoveal region, change in foveal SRVD and FAZA were significant. This has implications for clinical trials outcome in diseased eyes where significant capillary dropout may occur in the parafovea.

AB - We examined the impact of axial length on superficial retinal vessel density (SRVD) and foveal avascular zone area (FAZA) measurement using optical coherence tomography angiography. The SRVD and FAZA were quantified before and after correction for magnification error associated with axial length variation. Although SRVD did not differ before and after correction for magnification error in the parafoveal region, change in foveal SRVD and FAZA were significant. This has implications for clinical trials outcome in diseased eyes where significant capillary dropout may occur in the parafovea.

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U2 - 10.1117/12.2270134

DO - 10.1117/12.2270134

M3 - Conference paper

AN - SCOPUS:85020628200

T3 - Progress in Biomedical Optics and Imaging - Proceedings of SPIE

BT - International Conference on Biophotonics V

A2 - Popp, Jurgen

A2 - Wilson, Brian C.

A2 - Sampson, David D.

A2 - Matthews, Dennis L.

A2 - Rubinsztein-Dunlop, Halina

PB - SPIE-SOC PHOTO-OPTICAL INSTRUMENTATION ENGINEERS

T2 - 5th International Conference on Biophotonics, ICOB 2017

Y2 - 30 April 2017 through 1 May 2017

ER -

Sampson DM , Gong P, An D, Menghini M, Hansen A, Mackey DA et al. Axial length variation impacts on retinal vessel density and foveal avascular zone area measurement using optical coherence tomography angiography. In Popp J, Wilson BC, Sampson DD, Matthews DL, Rubinsztein-Dunlop H, editors, International Conference on Biophotonics V. SPIE-SOC PHOTO-OPTICAL INSTRUMENTATION ENGINEERS. 2017. 1034017. (Progress in Biomedical Optics and Imaging - Proceedings of SPIE). doi: 10.1117/12.2270134

Axial length variation impacts on retinal vessel density and foveal avascular zone area measurement using optical coherence tomography angiography

Abstract

Publication series

Conference

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Fred Chen

Axial Length Variation Impacts on Superficial Retinal Vessel Density and Foveal Avascular Zone Area Measurements Using Optical Coherence Tomography Angiography

Cite this

Axial length variation impacts on retinal vessel density and foveal avascular zone area measurement using optical coherence tomography angiography

Abstract

Publication series

Conference

Access to Document

Other files and links

Fingerprint

Projects

Fred Chen

Research output

Axial Length Variation Impacts on Superficial Retinal Vessel Density and Foveal Avascular Zone Area Measurements Using Optical Coherence Tomography Angiography

Cite this