Auxiliary partial orthotopic liver transplantation in acute liver failure due to hepatitis B

S. Saigal; P. Srinivasan; J. Devlin; Bastiaan De Boer; B. Thomas; B. Portmann; N.D. Heaton; J. O'Grady; M. Rela

doi:10.1111/j.1432-2277.2002.tb00180.x

Auxiliary partial orthotopic liver transplantation in acute liver failure due to hepatitis B

S. Saigal, P. Srinivasan, J. Devlin, Bastiaan De Boer, B. Thomas, B. Portmann, N.D. Heaton, J. O'Grady, M. Rela

Research output: Contribution to journal › Review article

4 Citations (Scopus)

Abstract

Auxiliary partial orthotopic liver transplantation is an alternative therapeutic modality in acute liver failure, wherein the capacity of native liver to regenerate is preserved. A case of acute liver failure due to hepatitis B in an 18-year-old male patient treated with an auxiliary left lateral segment graft is described. There was no recurrence of hepatitis B in the auxiliary graft and the patient cleared the virus after 9 months whilst receiving lamivudine. Immunosuppression was withdrawn at 14 months, and the auxiliary graft atrophied secondary to hepatic arterial conduit thrombosis, possibly precipitated by immunosuppression withdrawal. The native liver regenerated completely, and the patient is well and off immunosuppressive and antiviral therapy 3 years after transplantation. Auxiliary partial orthotopic liver transplantation is an attractive treatment option in acute liver failure due to hepatitis B infection and allows a life free of long-term immunosuppression.

Original language	English
Pages (from-to)	369-373
Journal	Transplant International
Volume	15
Issue number	N/A
DOIs	https://doi.org/10.1111/j.1432-2277.2002.tb00180.x
Publication status	Published - 2002

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title = "Auxiliary partial orthotopic liver transplantation in acute liver failure due to hepatitis B",

abstract = "Auxiliary partial orthotopic liver transplantation is an alternative therapeutic modality in acute liver failure, wherein the capacity of native liver to regenerate is preserved. A case of acute liver failure due to hepatitis B in an 18-year-old male patient treated with an auxiliary left lateral segment graft is described. There was no recurrence of hepatitis B in the auxiliary graft and the patient cleared the virus after 9 months whilst receiving lamivudine. Immunosuppression was withdrawn at 14 months, and the auxiliary graft atrophied secondary to hepatic arterial conduit thrombosis, possibly precipitated by immunosuppression withdrawal. The native liver regenerated completely, and the patient is well and off immunosuppressive and antiviral therapy 3 years after transplantation. Auxiliary partial orthotopic liver transplantation is an attractive treatment option in acute liver failure due to hepatitis B infection and allows a life free of long-term immunosuppression.",

author = "S. Saigal and P. Srinivasan and J. Devlin and {De Boer}, Bastiaan and B. Thomas and B. Portmann and N.D. Heaton and J. O'Grady and M. Rela",

year = "2002",

doi = "10.1111/j.1432-2277.2002.tb00180.x",

language = "English",

volume = "15",

pages = "369--373",

journal = "Transplant International",

issn = "0934-0874",

publisher = "John Wiley & Sons",

number = "N/A",

}

TY - JOUR

T1 - Auxiliary partial orthotopic liver transplantation in acute liver failure due to hepatitis B

AU - Saigal, S.

AU - Srinivasan, P.

AU - Devlin, J.

AU - De Boer, Bastiaan

AU - Thomas, B.

AU - Portmann, B.

AU - Heaton, N.D.

AU - O'Grady, J.

AU - Rela, M.

PY - 2002

Y1 - 2002

N2 - Auxiliary partial orthotopic liver transplantation is an alternative therapeutic modality in acute liver failure, wherein the capacity of native liver to regenerate is preserved. A case of acute liver failure due to hepatitis B in an 18-year-old male patient treated with an auxiliary left lateral segment graft is described. There was no recurrence of hepatitis B in the auxiliary graft and the patient cleared the virus after 9 months whilst receiving lamivudine. Immunosuppression was withdrawn at 14 months, and the auxiliary graft atrophied secondary to hepatic arterial conduit thrombosis, possibly precipitated by immunosuppression withdrawal. The native liver regenerated completely, and the patient is well and off immunosuppressive and antiviral therapy 3 years after transplantation. Auxiliary partial orthotopic liver transplantation is an attractive treatment option in acute liver failure due to hepatitis B infection and allows a life free of long-term immunosuppression.

AB - Auxiliary partial orthotopic liver transplantation is an alternative therapeutic modality in acute liver failure, wherein the capacity of native liver to regenerate is preserved. A case of acute liver failure due to hepatitis B in an 18-year-old male patient treated with an auxiliary left lateral segment graft is described. There was no recurrence of hepatitis B in the auxiliary graft and the patient cleared the virus after 9 months whilst receiving lamivudine. Immunosuppression was withdrawn at 14 months, and the auxiliary graft atrophied secondary to hepatic arterial conduit thrombosis, possibly precipitated by immunosuppression withdrawal. The native liver regenerated completely, and the patient is well and off immunosuppressive and antiviral therapy 3 years after transplantation. Auxiliary partial orthotopic liver transplantation is an attractive treatment option in acute liver failure due to hepatitis B infection and allows a life free of long-term immunosuppression.

U2 - 10.1111/j.1432-2277.2002.tb00180.x

DO - 10.1111/j.1432-2277.2002.tb00180.x

M3 - Review article

SN - 0934-0874

VL - 15

SP - 369

EP - 373

JO - Transplant International

JF - Transplant International

IS - N/A

ER -

Auxiliary partial orthotopic liver transplantation in acute liver failure due to hepatitis B

Abstract

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