Autoantibody Production in Cancer - The Humoral Immune Response toward Autologous Antigens in Cancer Patients

P. Zaenker, E.S. Gray, Melanie R. Ziman

    Research output: Contribution to journalReview article

    74 Citations (Scopus)

    Abstract

    © 2016 The Authors.A link between autoimmune responses and cancer via autoantibodies was first described in the 1950s. Since, autoantibodies have been studied for their potential use as cancer biomarkers, however the exact causes of their production remain to be elucidated. This review summarizes current theories of the causes of autoantibody production in cancer, namely: 1) defects in tolerance and inflammation, 2) changes in protein expression levels, 3) altered protein structure, and 4) cellular death mechanisms. We also highlight the need for further research into this field to improve our understanding of autoantibodies as biomarkers for cancer development and progression.
    Original languageEnglish
    Pages (from-to)477-483
    Number of pages7
    JournalAutoimmunity Reviews
    Volume15
    Issue number5
    DOIs
    Publication statusPublished - 2016

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