TY - JOUR
T1 - Autoantibody Production in Cancer - The Humoral Immune Response toward Autologous Antigens in Cancer Patients
AU - Zaenker, P.
AU - Gray, E.S.
AU - Ziman, Melanie R.
PY - 2016/5/1
Y1 - 2016/5/1
N2 - © 2016 The Authors.A link between autoimmune responses and cancer via autoantibodies was first described in the 1950s. Since, autoantibodies have been studied for their potential use as cancer biomarkers, however the exact causes of their production remain to be elucidated. This review summarizes current theories of the causes of autoantibody production in cancer, namely: 1) defects in tolerance and inflammation, 2) changes in protein expression levels, 3) altered protein structure, and 4) cellular death mechanisms. We also highlight the need for further research into this field to improve our understanding of autoantibodies as biomarkers for cancer development and progression.
AB - © 2016 The Authors.A link between autoimmune responses and cancer via autoantibodies was first described in the 1950s. Since, autoantibodies have been studied for their potential use as cancer biomarkers, however the exact causes of their production remain to be elucidated. This review summarizes current theories of the causes of autoantibody production in cancer, namely: 1) defects in tolerance and inflammation, 2) changes in protein expression levels, 3) altered protein structure, and 4) cellular death mechanisms. We also highlight the need for further research into this field to improve our understanding of autoantibodies as biomarkers for cancer development and progression.
U2 - 10.1016/j.autrev.2016.01.017
DO - 10.1016/j.autrev.2016.01.017
M3 - Review article
C2 - 26827909
SN - 1568-9972
VL - 15
SP - 477
EP - 483
JO - Autoimmunity Reviews
JF - Autoimmunity Reviews
IS - 5
ER -
