Australian snake venoms: their identification and effect on human haemostasis

Lorraine Rhoda Marshall

    Research output: ThesisDoctoral Thesis

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    Abstract

    [Truncated] This thesis presents the first comprehensive study of the in vitro
    effects on human blood coagulation of the venoms of all 20
    Australian venomous snakes large enough to be considered a threat to
    humans. This systematic study, which includes for the first time
    six venoms never previously examined, has led to a considerable
    increase in understanding of the disturbances in blood coagulation
    following envenomation. The results contained in this thesis have
    important implications in the clinical management of snake bite
    victims in Australia.
    Venoms were studied using both established techniques and the
    application of new techniques developed in the course of this study.
    All venoms can now be classified as either procoagulant or
    anticoagulant in nature. The procoagulant activity of the venoms
    was characterised by determining the dependence or independence on
    various cofactors and the similarity of the venoms' activity to the
    active proenzymes of normal blood coagulation, thrombin and
    activated factor X. Anticoagulant activity was found to be dominant
    in four Australian venoms and in each case was shown by a variety of
    techniques to be antithromboplastic. Three well documented non
    Australian snake venoms were included in this thesis for comparative
    purposes. In addition they served to validate the findings using
    the techniques applied to the Australian venoms.
    Original languageEnglish
    QualificationDoctor of Philosophy
    Awarding Institution
    • The University of Western Australia
    DOIs
    Publication statusUnpublished - 1990

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