Abstract
Eph receptors and ephrin ligands are large families of cell surface proteins which have established roles in axonal growth and guidance. These are well characterized in the visual and somatosensory systems but are less well documented in the auditory pathway. We examined the possible functional role of two ephrin genes (ephrin-A2 and ephrinA5) in the auditory system by measuring auditory brainstem responses (ABR) to tone bursts from 6 to 30 kHz in ephrinA2 (-/-), ephrin-A5(-/-) and ephrin-A2A5(-/-) (knockout) mice. At high frequencies, the ephrin-A2A5(-/-) mice exhibited thresholds that were significantly lower than in wild-type mice by approximately 20 dB, suggesting ephrin-A2 and ephrin-A5 may have frequency-specific effects on the auditory system. There were also alterations in ABR wave peak amplitudes that were specific to each mouse strain which suggested both peripheral and central involvement of EphA-ephrin-A signalling in auditory function. (C) 2014 S. Karger AG, Basel
| Original language | English |
|---|---|
| Pages (from-to) | 115-126 |
| Number of pages | 12 |
| Journal | Audiology and Neurotology |
| Volume | 19 |
| Issue number | 2 |
| Early online date | 18 Jan 2014 |
| DOIs | |
| Publication status | Published - Mar 2014 |