Audio frequency in vivo optical coherence elastography

S.G. Adie; Brendan Kennedy; Julian Armstrong; Sergey Alexandrov; David Sampson

doi:10.1088/0031-9155/54/10/011

Audio frequency in vivo optical coherence elastography

S.G. Adie, Brendan Kennedy, Julian Armstrong, Sergey Alexandrov, David Sampson

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46 Citations (Scopus)

Abstract

We present a new approach to optical coherence elastography (OCE), which probes the local elastic properties of tissue by using optical coherence tomography to measure the effect of an applied stimulus in the audio frequency range. We describe the approach, based on analysis of the Bessel frequency spectrum of the interferometric signal detected from scatterers undergoing periodic motion in response to an applied stimulus. We present quantitative results of sub-micron excitation at 820 Hz in a layered phantom and the first such measurements in human skin in vivo.

Original language	English
Pages (from-to)	3129-3139
Journal	Physics in Medicine and Biology
Volume	54
DOIs	https://doi.org/10.1088/0031-9155/54/10/011
Publication status	Published - 2009

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title = "Audio frequency in vivo optical coherence elastography",

abstract = "We present a new approach to optical coherence elastography (OCE), which probes the local elastic properties of tissue by using optical coherence tomography to measure the effect of an applied stimulus in the audio frequency range. We describe the approach, based on analysis of the Bessel frequency spectrum of the interferometric signal detected from scatterers undergoing periodic motion in response to an applied stimulus. We present quantitative results of sub-micron excitation at 820 Hz in a layered phantom and the first such measurements in human skin in vivo.",

author = "S.G. Adie and Brendan Kennedy and Julian Armstrong and Sergey Alexandrov and David Sampson",

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AU - Adie, S.G.

AU - Kennedy, Brendan

AU - Armstrong, Julian

AU - Alexandrov, Sergey

AU - Sampson, David

PY - 2009

Y1 - 2009

N2 - We present a new approach to optical coherence elastography (OCE), which probes the local elastic properties of tissue by using optical coherence tomography to measure the effect of an applied stimulus in the audio frequency range. We describe the approach, based on analysis of the Bessel frequency spectrum of the interferometric signal detected from scatterers undergoing periodic motion in response to an applied stimulus. We present quantitative results of sub-micron excitation at 820 Hz in a layered phantom and the first such measurements in human skin in vivo.

AB - We present a new approach to optical coherence elastography (OCE), which probes the local elastic properties of tissue by using optical coherence tomography to measure the effect of an applied stimulus in the audio frequency range. We describe the approach, based on analysis of the Bessel frequency spectrum of the interferometric signal detected from scatterers undergoing periodic motion in response to an applied stimulus. We present quantitative results of sub-micron excitation at 820 Hz in a layered phantom and the first such measurements in human skin in vivo.

U2 - 10.1088/0031-9155/54/10/011

DO - 10.1088/0031-9155/54/10/011

M3 - Article

C2 - 19420415

SN - 0031-9155

VL - 54

SP - 3129

EP - 3139

JO - Physics in Medicine and Biology

JF - Physics in Medicine and Biology

ER -

Audio frequency in vivo optical coherence elastography

Abstract

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