Attenuation of ductus arteriosus intimal thickening in preterm sheep twins compared with singletons

Satoko Ito, Utako Yokoyama, Junichi Saito, Shinichi Sato, Haruo Usuda, Shimpei Watanabe, Ryuta Kitanishi, Yuichiro Miura, Masatoshi Saito, Takushi Hanita, Tadashi Matsuda, Yoshihiro Ishikawa

Research output: Contribution to journalArticlepeer-review

8 Citations (Scopus)

Abstract

Preterm twins have a higher morbidity rate of patent ductus arteriosus (PDA) than do singletons. However, the effect of multiple births on maturation of the ductus arteriosus (DA) has not been reported. Because intimal thickening (IT) is required for DA anatomical closure, we examined IT development in the DA of preterm twins and singletons. Sheep DA tissues obtained from preterm fetuses were subjected to elastica van Gieson staining to evaluate IT. The total IT score in each DA was the sum of the IT scores obtained from six evenly divided parts of the DA, which was positively correlated with gestational ages in singletons. Total IT scores were smaller in preterm twins than in singletons, although no difference in gestational age, birth weight, or gender ratio was observed. These data suggest that IT development of the DA is attenuated in sheep preterm twins, which may affect the higher morbidity of PDA.

Original languageEnglish
Pages (from-to)723-729
Number of pages7
JournalJournal of Physiological Sciences
Volume67
Issue number6
DOIs
Publication statusPublished - Nov 2017
Externally publishedYes

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