Attainment of LDL-cholesterol treatment goals in patients with familial hypercholesterolemia: 5-year SAFEHEART registry follow-up

L. Perez De Isla, R. Alonso, Gerald Watts, N. Mata, A. Saltijeral Cerezo, O. Muñiz, F. Fuentes, J.L. Diaz-Diaz, R. De Andrés, D. Zambón, P. Rubio-Marin, M.A. Barba-Romero, P. Saenz, J.F. Sanchez Muñoz-Torrero, C. Martinez-Faedo, J.P. Miramontes-Gonzalez, L. Badimón, P. Mata, R. Aguado, F. AlmagroF. Arrieta, M.Á. Barba, Á. Brea, J.M. Cepeda, G. Díaz, J.L. Díaz, J.A. Garrido, L. Irigoyen, L. Manjón, A. Martin, M. Piedecausa, M. Mauri, P. Miramontes, F. Pereyra, L. Pérez, X. Pintó, P. Pujante, E. Ruiz, J.F. Sánchez, J.I. Vidal, R. Argüeso

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Abstract

© 2016 American College of Cardiology Foundation. Background Familial hypercholesterolemia (FH) is the most common genetic disorder associated with premature atherosclerotic cardiovascular disease (ASCVD). There are sparse data on attainment of treatment targets; large registries that reflect real-life clinical practice can uniquely provide this information. Objectives We sought to evaluate the achievement of low-density lipoprotein cholesterol (LDL-C) treatment goals in FH patients enrolled in a large national registry. Methods The SAFEHEART study (Spanish Familial Hypercholesterolemia Cohort Study) is a large, ongoing registry of molecularly defined patients with heterozygous FH treated in Spain. The attainment of guideline-recommended plasma LDL-C goals at entry and follow-up was investigated in relation to use of lipid-lowering therapy (LLT). Results The study recruited 4,132 individuals (3,745 of whom were ≥18 years of age); 2,752 of those enrolled were molecularly diagnosed FH cases. Mean follow-up was 5.1 ± 3.1 years; 71.8% of FH cases were on maximal LLT, and an LDL-C treatment target
Original languageEnglish
Pages (from-to)1278-1285
JournalJournal of the American College of Cardiology
Volume67
Issue number11
DOIs
Publication statusPublished - 2016

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    Perez De Isla, L., Alonso, R., Watts, G., Mata, N., Saltijeral Cerezo, A., Muñiz, O., Fuentes, F., Diaz-Diaz, J. L., De Andrés, R., Zambón, D., Rubio-Marin, P., Barba-Romero, M. A., Saenz, P., Sanchez Muñoz-Torrero, J. F., Martinez-Faedo, C., Miramontes-Gonzalez, J. P., Badimón, L., Mata, P., Aguado, R., ... Argüeso, R. (2016). Attainment of LDL-cholesterol treatment goals in patients with familial hypercholesterolemia: 5-year SAFEHEART registry follow-up. Journal of the American College of Cardiology, 67(11), 1278-1285. https://doi.org/10.1016/j.jacc.2016.01.008