Asymptomatic progressive multifocal leukoencephalopathy during natalizumab therapy with treatment

Marzena J. Fabis-Pedrini, Wen Xu, Jason Burton, William M. Carroll, Allan G. Kermode

Research output: Contribution to journalArticle

2 Citations (Scopus)

Abstract

© 2015 Elsevier Ltd. All rights reserved. We report a case of asymptomatic progressive multifocal leukoencephalopathy (PML) detected on regular MRI screening in a 40-year-old patient with subsequent benign course with 12 months follow-up. The patient had a history of aggressive inflammatory multiple sclerosis, prior mitoxantrone therapy, Stratify John Cunningham Virus test positivity (Quest Diagnostics, Madison, NJ, USA), and 5 years of natalizumab monotherapy. The initial MRI detection of PML was both atypical and subtle. Early diagnosis and intervention, and pre-emptive treatment for immune reconstitution inflammatory syndrome with high dose steroids, as well as empirical mirtazapine and mefloquine, were associated with a benign PML disease course and outcome.
Original languageEnglish
Pages (from-to)145-147
Number of pages3
JournalJournal of Clinical Neuroscience
Volume25
Early online date4 Jan 2016
DOIs
Publication statusPublished - 2016

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Progressive Multifocal Leukoencephalopathy
Immune Reconstitution Inflammatory Syndrome
JC Virus
Mefloquine
Mitoxantrone
Multiple Sclerosis
Early Diagnosis
Therapeutics
Steroids
Natalizumab

Cite this

Fabis-Pedrini, Marzena J. ; Xu, Wen ; Burton, Jason ; Carroll, William M. ; Kermode, Allan G. / Asymptomatic progressive multifocal leukoencephalopathy during natalizumab therapy with treatment. In: Journal of Clinical Neuroscience. 2016 ; Vol. 25. pp. 145-147.
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Asymptomatic progressive multifocal leukoencephalopathy during natalizumab therapy with treatment. / Fabis-Pedrini, Marzena J.; Xu, Wen; Burton, Jason; Carroll, William M.; Kermode, Allan G.

In: Journal of Clinical Neuroscience, Vol. 25, 2016, p. 145-147.

Research output: Contribution to journalArticle

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