Asymptomatic progressive multifocal leukoencephalopathy during natalizumab therapy with treatment

Marzena J. Fabis-Pedrini, Wen Xu, Jason Burton, William M. Carroll, Allan G. Kermode

Research output: Contribution to journalArticle

4 Citations (Scopus)

Abstract

© 2015 Elsevier Ltd. All rights reserved. We report a case of asymptomatic progressive multifocal leukoencephalopathy (PML) detected on regular MRI screening in a 40-year-old patient with subsequent benign course with 12 months follow-up. The patient had a history of aggressive inflammatory multiple sclerosis, prior mitoxantrone therapy, Stratify John Cunningham Virus test positivity (Quest Diagnostics, Madison, NJ, USA), and 5 years of natalizumab monotherapy. The initial MRI detection of PML was both atypical and subtle. Early diagnosis and intervention, and pre-emptive treatment for immune reconstitution inflammatory syndrome with high dose steroids, as well as empirical mirtazapine and mefloquine, were associated with a benign PML disease course and outcome.
Original languageEnglish
Pages (from-to)145-147
Number of pages3
JournalJournal of Clinical Neuroscience
Volume25
Early online date4 Jan 2016
DOIs
Publication statusPublished - 2016

Fingerprint

Dive into the research topics of 'Asymptomatic progressive multifocal leukoencephalopathy during natalizumab therapy with treatment'. Together they form a unique fingerprint.

Cite this