Projects per year
Research question: Are asthma and allergies more common in adolescents conceived with assisted reproductive technologies (ART) compared with adolescents conceived without? Design: The Growing Up Healthy Study (GUHS) is a prospective cohort study including ART-conceived offspring born between 1991 and 2001 in Perth, Australia. Their long-term health outcomes, including asthma and allergy parameters, were compared with those of their counterparts conceived without ART from the Raine Study Generation 2 (Gen2), born in 1989–1991. At age 14, 152 GUHS and 1845 Gen2 participants completed the following assessments: the International Studies of Asthma and Allergies in Childhood (ISAAC) questionnaire, spirometry, methacholine challenge testing and skin prick testing (SPT). Results: No differences were detected in the prevalence of current asthma (7.7% versus 10.8%, adjusted odds ratio [aOR] 0.82 (95% CI 0.44–1.52), P = 0.530). Spirometry-measured lung volumes were larger in the ART adolescents. Bronchial hyperresponsiveness was less prevalent in the ART cohort (8.8 versus 18.6%, P = 0.006). Current allergic rhinoconjunctivitis (ARC) rates were significantly higher in the ART cohort (32.4% versus 25.2%, aOR 1.52 [95% CI 1.03–2.26], P = 0.036), with no cohort differences in atopic dermatitis. Food allergies were more prevalent in the ART cohort (20.7 versus 10.9%, aOR 1.89 [95% CI 1.17–3.06], P = 0.010) with more adolescents having a positive SPT (68.0% versus 45.4%, aOR 3.03 [95% 1.99–4.63], P < 0.001). Conclusions: This study reports no differences in asthma prevalence, slightly altered lung function, an increase in ARC, food allergies and positive SPT in the ART-conceived adolescents. These findings are important to families and healthcare providers and may open up possibilities for targeted screening and treatment. Further studies are required to confirm these findings.
|Number of pages||11|
|Journal||Reproductive Biomedicine Online|
|Publication status||Published - Dec 2022|
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- 3 Finished
The Long Term Consequences of Assisted Reproduction on Development of the Offspring: A Prospective Cohort Study
Hart, R., Pennell, C., Doherty, D., Robinson, M. & Norman, R.
National Health & Medical Research Council NHMRC
1/01/13 → 31/12/18
403981: Childhood Precursors of Adult Cardiovascular Disease, Obesity and Diabetes- 16 Year Follow up of a Longitudinal Cohort
Beilin, L., Palmer, L., Oddy, W., Mori, T., Kendall, G. & Hands, B.
1/01/06 → 31/12/09
211912 - Developmental Aspects of Respiratory Inflammation, Allergy and Asthma.
Sly, P., Upham, J., Le Souef, P., Stick, S., Stumbles, P., Thomas, W. & Holt, P.
1/01/02 → 31/12/06