Associations of neighborhood environment with brain imaging outcomes in the Australian Imaging, Biomarkers and Lifestyle cohort

Ester Cerin, Stephanie R. Rainey-Smith, David Ames, Nicola T. Lautenschlager, S. Lance Macaulay, Christopher Fowler, Joanne S. Robertson, Christopher C. Rowe, Paul Maruff, Ralph N. Martins, Colin L. Masters, Kathryn A. Ellis

Research output: Contribution to journalArticle

3 Citations (Scopus)

Abstract

Introduction: "Walkable" neighborhoods offer older adults opportunities for activities that may benefit cognition-related biological mechanisms. These have not previously been examined in this context.

Methods: We objectively assessed neighborhood walkability for participants (n = 146) from the Australian Imaging, Biomarkers and Lifestyle study with apolipoprotein E (APOE) genotype and two 18-month-apart brain volumetric and/or amyloid beta burden assessments. Linear mixed models estimated associations of neighborhood walkability with levels and changes in brain imaging outcomes, the moderating effect of APOE epsilon 4 status, and the extent to which associations were explained by physical activity.

Results: Cross-sectionally, neighborhood walkability was predictive of better neuroimaging outcomes except for left hippocampal volume. These associations were to a small extent explained by physical activity. APOE epsilon 4 carriers showed slower worsening of outcomes if living in walkable neighborhoods.

Discussion: These findings indicate associations between neighborhood walkability and brain imaging measures (especially in APOE epsilon 4 carriers) minimally attributable to physical activity. (C) 2016 the Alzheimer's Association. Published by Elsevier Inc. All rights reserved.

Original languageEnglish
Pages (from-to)388-398
Number of pages11
JournalALZHEIMERS & DEMENTIA
Volume13
Issue number4
DOIs
Publication statusPublished - Apr 2017
Externally publishedYes

Cite this

Cerin, E., Rainey-Smith, S. R., Ames, D., Lautenschlager, N. T., Macaulay, S. L., Fowler, C., ... Ellis, K. A. (2017). Associations of neighborhood environment with brain imaging outcomes in the Australian Imaging, Biomarkers and Lifestyle cohort. ALZHEIMERS & DEMENTIA, 13(4), 388-398. https://doi.org/10.1016/j.jalz.2016.06.2364
Cerin, Ester ; Rainey-Smith, Stephanie R. ; Ames, David ; Lautenschlager, Nicola T. ; Macaulay, S. Lance ; Fowler, Christopher ; Robertson, Joanne S. ; Rowe, Christopher C. ; Maruff, Paul ; Martins, Ralph N. ; Masters, Colin L. ; Ellis, Kathryn A. / Associations of neighborhood environment with brain imaging outcomes in the Australian Imaging, Biomarkers and Lifestyle cohort. In: ALZHEIMERS & DEMENTIA. 2017 ; Vol. 13, No. 4. pp. 388-398.
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abstract = "Introduction: {"}Walkable{"} neighborhoods offer older adults opportunities for activities that may benefit cognition-related biological mechanisms. These have not previously been examined in this context.Methods: We objectively assessed neighborhood walkability for participants (n = 146) from the Australian Imaging, Biomarkers and Lifestyle study with apolipoprotein E (APOE) genotype and two 18-month-apart brain volumetric and/or amyloid beta burden assessments. Linear mixed models estimated associations of neighborhood walkability with levels and changes in brain imaging outcomes, the moderating effect of APOE epsilon 4 status, and the extent to which associations were explained by physical activity.Results: Cross-sectionally, neighborhood walkability was predictive of better neuroimaging outcomes except for left hippocampal volume. These associations were to a small extent explained by physical activity. APOE epsilon 4 carriers showed slower worsening of outcomes if living in walkable neighborhoods.Discussion: These findings indicate associations between neighborhood walkability and brain imaging measures (especially in APOE epsilon 4 carriers) minimally attributable to physical activity. (C) 2016 the Alzheimer's Association. Published by Elsevier Inc. All rights reserved.",
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Cerin, E, Rainey-Smith, SR, Ames, D, Lautenschlager, NT, Macaulay, SL, Fowler, C, Robertson, JS, Rowe, CC, Maruff, P, Martins, RN, Masters, CL & Ellis, KA 2017, 'Associations of neighborhood environment with brain imaging outcomes in the Australian Imaging, Biomarkers and Lifestyle cohort' ALZHEIMERS & DEMENTIA, vol. 13, no. 4, pp. 388-398. https://doi.org/10.1016/j.jalz.2016.06.2364

Associations of neighborhood environment with brain imaging outcomes in the Australian Imaging, Biomarkers and Lifestyle cohort. / Cerin, Ester; Rainey-Smith, Stephanie R.; Ames, David; Lautenschlager, Nicola T.; Macaulay, S. Lance; Fowler, Christopher; Robertson, Joanne S.; Rowe, Christopher C.; Maruff, Paul; Martins, Ralph N.; Masters, Colin L.; Ellis, Kathryn A.

In: ALZHEIMERS & DEMENTIA, Vol. 13, No. 4, 04.2017, p. 388-398.

Research output: Contribution to journalArticle

TY - JOUR

T1 - Associations of neighborhood environment with brain imaging outcomes in the Australian Imaging, Biomarkers and Lifestyle cohort

AU - Cerin, Ester

AU - Rainey-Smith, Stephanie R.

AU - Ames, David

AU - Lautenschlager, Nicola T.

AU - Macaulay, S. Lance

AU - Fowler, Christopher

AU - Robertson, Joanne S.

AU - Rowe, Christopher C.

AU - Maruff, Paul

AU - Martins, Ralph N.

AU - Masters, Colin L.

AU - Ellis, Kathryn A.

PY - 2017/4

Y1 - 2017/4

N2 - Introduction: "Walkable" neighborhoods offer older adults opportunities for activities that may benefit cognition-related biological mechanisms. These have not previously been examined in this context.Methods: We objectively assessed neighborhood walkability for participants (n = 146) from the Australian Imaging, Biomarkers and Lifestyle study with apolipoprotein E (APOE) genotype and two 18-month-apart brain volumetric and/or amyloid beta burden assessments. Linear mixed models estimated associations of neighborhood walkability with levels and changes in brain imaging outcomes, the moderating effect of APOE epsilon 4 status, and the extent to which associations were explained by physical activity.Results: Cross-sectionally, neighborhood walkability was predictive of better neuroimaging outcomes except for left hippocampal volume. These associations were to a small extent explained by physical activity. APOE epsilon 4 carriers showed slower worsening of outcomes if living in walkable neighborhoods.Discussion: These findings indicate associations between neighborhood walkability and brain imaging measures (especially in APOE epsilon 4 carriers) minimally attributable to physical activity. (C) 2016 the Alzheimer's Association. Published by Elsevier Inc. All rights reserved.

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KW - Community dwellers

KW - PHYSICAL-ACTIVITY

KW - ALZHEIMERS-DISEASE

KW - OLDER-ADULTS

KW - COGNITIVE FUNCTION

KW - ENRICHMENT

KW - DESTINATIONS

KW - DEPOSITION

KW - GENOTYPE

KW - DECLINE

KW - WALKING

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DO - 10.1016/j.jalz.2016.06.2364

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