Associations of maternal prepregnancy body mass index and gestational weight gain with cardio-metabolic risk factors in adolescent offspring: a prospective cohort study

R. Gaillard, M. Welten, W. H. Oddy, L. J. Beilin, T. A. Mori, Vincent W V Jaddoe, R-C Huang

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31 Citations (Scopus)

Abstract

ObjectiveTo assess the associations of maternal prepregnancy body mass index (BMI) and rates of early-pregnancy, mid-pregnancy and total gestational weight gain with adolescent body fat distribution and cardio-metabolic outcomes.

DesignPopulation-based prospective cohort study.

SettingWestern Australia.

PopulationThousand three hundred and ninety-two mothers and their children.

MethodsMaternal prepregnancy weight was assessed by questionnaire. Maternal weights at a mean of 16.52.2 SD and 34.11.5 SD weeks of gestation were obtained from medical records. Offspring adiposity and cardio-metabolic outcomes were assessed at a median age 17.0years [95% confidence interval (CI) range: 16.7, 17.7].

Main outcome measuresAdolescent BMI, waist circumference (WC), waist-to-hip ratio (WHR), blood pressure, total and HDL-cholesterol, triglycerides, insulin, glucose and HOMA-IR.

ResultsHigher prepregnancy BMI was associated with higher adolescent BMI, WC, WHR, systolic blood pressure, insulin, glucose and HOMA-IR levels (P-values

ConclusionsHigher maternal prepregnancy BMI and early-pregnancy weight gain rate are associated with an adverse adolescent cardio-metabolic profile. These associations are largely mediated by adolescent BMI.

Tweetable abstractPrepregnancy BMI and early-pregnancy WG rate are associated with adverse adolescent cardio-metabolic profile.

Tweetable abstract Prepregnancy BMI and early-pregnancy WG rate are associated with adverse adolescent cardio-metabolic profile.

Original languageEnglish
Pages (from-to)207-216
Number of pages10
JournalBJOG: an International Journal of Obstetrics and Gynecology
Volume123
Issue number2
DOIs
Publication statusPublished - Jan 2016

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