ObjectiveTo assess the associations of maternal prepregnancy body mass index (BMI) and rates of early-pregnancy, mid-pregnancy and total gestational weight gain with adolescent body fat distribution and cardio-metabolic outcomes.
DesignPopulation-based prospective cohort study.
PopulationThousand three hundred and ninety-two mothers and their children.
MethodsMaternal prepregnancy weight was assessed by questionnaire. Maternal weights at a mean of 16.52.2 SD and 34.11.5 SD weeks of gestation were obtained from medical records. Offspring adiposity and cardio-metabolic outcomes were assessed at a median age 17.0years [95% confidence interval (CI) range: 16.7, 17.7].
Main outcome measuresAdolescent BMI, waist circumference (WC), waist-to-hip ratio (WHR), blood pressure, total and HDL-cholesterol, triglycerides, insulin, glucose and HOMA-IR.
ResultsHigher prepregnancy BMI was associated with higher adolescent BMI, WC, WHR, systolic blood pressure, insulin, glucose and HOMA-IR levels (P-values
ConclusionsHigher maternal prepregnancy BMI and early-pregnancy weight gain rate are associated with an adverse adolescent cardio-metabolic profile. These associations are largely mediated by adolescent BMI.
Tweetable abstractPrepregnancy BMI and early-pregnancy WG rate are associated with adverse adolescent cardio-metabolic profile.
Tweetable abstract Prepregnancy BMI and early-pregnancy WG rate are associated with adverse adolescent cardio-metabolic profile.
|Number of pages||10|
|Journal||BJOG: an International Journal of Obstetrics and Gynecology|
|Publication status||Published - Jan 2016|