Projects per year
Abstract
Phthalates are ubiquitous environmental chemicals with endocrine disrupting properties and potentially obesogenic effects. We hypothesised that antenatal phthalate exposure may influence growth and adiposity patterns in girls through childhood into adolescence. Among 1342 Raine Study singleton females, 462 had maternal serum and at least one outcome available up to 20 years of age. Individuals’ maternal serum collected at 18 and 34 weeks gestation was pooled and analyzed for concentrations of 32 metabolites of 15 phthalate diesters. Cox regression and linear models were used to determine associations between maternal phthalate levels and age at menarche, change in height and weight z-scores between birth and two years, height from birth to 20 years, BMI from two to 20 years, deviation from mid-parental height at age 20 and DEXA scan measures at age 20. Weak negative associations were detected with some phthalate metabolites and change in height and weight z-score during infancy. Weak positive associations between some of the high molecular weight phthalate metabolites and height z-score were detected during childhood. While still within the normal range, age at menarche was slightly delayed in girls with higher prenatal exposure to the higher molecular weight phthalate metabolites. We derived some associations between prenatal phthalate exposure with early growth patterns and age at menarche.
Original language | English |
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Article number | 4725 |
Journal | International Journal of Environmental Research and Public Health |
Volume | 18 |
Issue number | 9 |
DOIs | |
Publication status | Published - 1 May 2021 |
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Dive into the research topics of 'Associations between prenatal exposure to phthalates and timing of menarche and growth and adiposity into adulthood: A twenty-years birth cohort study'. Together they form a unique fingerprint.Projects
- 3 Finished
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The Early Life Origins of Impaired Testicular Function - A Prospective Cohort Study
Hart, R. (Investigator 01), Hickey, M. (Investigator 02), Skakkebaek, N. (Investigator 03), Junk, S. (Investigator 04), Doherty, D. (Investigator 05) & Sloboda, D. (Investigator 06)
NHMRC National Health and Medical Research Council
1/01/10 → 31/12/12
Project: Research
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403968: The Fetal and Early Childhood Origins of PCOS: A Prospective Cohort Study
Hickey, M. (Chief Investigator), Hart, R. (Chief Investigator), Sloboda, D. (Chief Investigator), Doherty, D. (Chief Investigator), Franks, S. (Chief Investigator) & Davies, M. (Chief Investigator)
1/01/06 → 31/12/08
Project: Research
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211912 - Developmental Aspects of Respiratory Inflammation, Allergy and Asthma.
Sly, P. (Chief Investigator), Upham, J. (Chief Investigator), Le Souef, P. (Chief Investigator), Stick, S. (Chief Investigator), Stumbles, P. (Chief Investigator), Thomas, W. (Chief Investigator) & Holt, P. (Chief Investigator)
1/01/02 → 31/12/06
Project: Research