Associations between maternal body composition and appetite hormones and macronutrients in human milk

Sambavi Kugananthan, Zoya Gridneva, Ching T. Lai, Anna R. Hepworth, Peter J. Mark, Foteini Kakulas, Donna T. Geddes

Research output: Contribution to journalArticle

17 Citations (Scopus)

Abstract

Human milk (HM) appetite hormones and macronutrients may mediate satiety in breastfed infants. This study investigated associations between maternal adiposity and concentrations of HM leptin, adiponectin, protein and lactose, and whether these concentrations and the relationship between body mass index and percentage fat mass (%FM) in a breastfeeding population change over the first year of lactation. Lactating women (n = 59) provided milk samples (n = 283) at the 2nd, 5th, 9th and/or 12th month of lactation. Concentrations of leptin, adiponectin, total protein and lactose were measured. Maternal %FM was measured using bioimpedance spectroscopy. Higher maternal %FM was associated with higher leptin concentrations in both whole (0.006 ± 0.002 ng/mL, p = 0.008) and skim HM (0.005 ± 0.002 ng/mL, p = 0.007), and protein (0.16 ± 0.07 g/L, p = 0.028) concentrations. Adiponectin and lactose concentrations were not associated with %FM (0.01 ± 0.06 ng/mL, p = 0.81; 0.08 ± 0.11 g/L, p = 0.48, respectively). Whole milk concentrations of adiponectin and leptin did not differ significantly over the first year of lactation. These findings suggest that the level of maternal adiposity during lactation may influence the early appetite programming of breastfed infants by modulating concentrations of HM components.

Original languageEnglish
Article number252
Number of pages18
JournalNutrients
Volume9
Issue number3
DOIs
Publication statusPublished - 9 Mar 2017

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adiponectin
Adiponectin
Human Milk
Appetite
breast milk
appetite
Leptin
Body Composition
leptin
Lactation
body composition
Lactose
lactation
Mothers
hormones
Hormones
lactose
Adiposity
adiposity
Milk

Cite this

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title = "Associations between maternal body composition and appetite hormones and macronutrients in human milk",
abstract = "Human milk (HM) appetite hormones and macronutrients may mediate satiety in breastfed infants. This study investigated associations between maternal adiposity and concentrations of HM leptin, adiponectin, protein and lactose, and whether these concentrations and the relationship between body mass index and percentage fat mass ({\%}FM) in a breastfeeding population change over the first year of lactation. Lactating women (n = 59) provided milk samples (n = 283) at the 2nd, 5th, 9th and/or 12th month of lactation. Concentrations of leptin, adiponectin, total protein and lactose were measured. Maternal {\%}FM was measured using bioimpedance spectroscopy. Higher maternal {\%}FM was associated with higher leptin concentrations in both whole (0.006 ± 0.002 ng/mL, p = 0.008) and skim HM (0.005 ± 0.002 ng/mL, p = 0.007), and protein (0.16 ± 0.07 g/L, p = 0.028) concentrations. Adiponectin and lactose concentrations were not associated with {\%}FM (0.01 ± 0.06 ng/mL, p = 0.81; 0.08 ± 0.11 g/L, p = 0.48, respectively). Whole milk concentrations of adiponectin and leptin did not differ significantly over the first year of lactation. These findings suggest that the level of maternal adiposity during lactation may influence the early appetite programming of breastfed infants by modulating concentrations of HM components.",
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Associations between maternal body composition and appetite hormones and macronutrients in human milk. / Kugananthan, Sambavi; Gridneva, Zoya; Lai, Ching T.; Hepworth, Anna R.; Mark, Peter J.; Kakulas, Foteini; Geddes, Donna T.

In: Nutrients, Vol. 9, No. 3, 252, 09.03.2017.

Research output: Contribution to journalArticle

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AU - Kugananthan, Sambavi

AU - Gridneva, Zoya

AU - Lai, Ching T.

AU - Hepworth, Anna R.

AU - Mark, Peter J.

AU - Kakulas, Foteini

AU - Geddes, Donna T.

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KW - Leptin

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KW - Percentage fat mass

KW - Protein

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