Associations between KIR epitope combinations expressed by HLA-B/-C haplotypes found in an HIV-1 infected study population may influence NK mediated immune responses

Silvana Gaudieri, D. Nolan, E. Mckinnon, C.S. Witt, S. Mallal, Frank Christiansen

    Research output: Contribution to journalReview article

    30 Citations (Scopus)

    Abstract

    The Killer Ig-like receptors (KIRs) on NK cells regulate NK activity via the recognition of specific HLA class I products on the surface of target cells. To investigate the level at which these genetically polymorphic receptors and ligands influence HIV-1 disease progression, we examined the effect of KIR and HLA genotype on HIV outcome. We observed a significant association between particular combinations of KIR epitopes expressed by HLA-B/-C haplotypes and propose that the repertoire of KIR epitopes expressed by HLA-B and HLA-C alleles within the context of particular haplotypes may be an important component of the NK mediated immune response to HIV and/or other infectious pathogens. Crown Copyright (C) 2004 Published by Elsevier Ltd. All rights reserved.
    Original languageEnglish
    Pages (from-to)557-560
    JournalMolecular Immunology
    Volume42
    DOIs
    Publication statusPublished - 2005

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