Associations between KIR epitope combinations expressed by HLA-B/-C haplotypes found in an HIV-1 infected study population may influence NK mediated immune responses

Silvana Gaudieri; D. Nolan; E. Mckinnon; C.S. Witt; S. Mallal; Frank Christiansen

doi:10.1016/j.molimm.2004.07.041

Associations between KIR epitope combinations expressed by HLA-B/-C haplotypes found in an HIV-1 infected study population may influence NK mediated immune responses

Silvana Gaudieri, D. Nolan, E. Mckinnon, C.S. Witt, S. Mallal, Frank Christiansen

Research output: Contribution to journal › Review article › peer-review

32 Citations (Web of Science)

Abstract

The Killer Ig-like receptors (KIRs) on NK cells regulate NK activity via the recognition of specific HLA class I products on the surface of target cells. To investigate the level at which these genetically polymorphic receptors and ligands influence HIV-1 disease progression, we examined the effect of KIR and HLA genotype on HIV outcome. We observed a significant association between particular combinations of KIR epitopes expressed by HLA-B/-C haplotypes and propose that the repertoire of KIR epitopes expressed by HLA-B and HLA-C alleles within the context of particular haplotypes may be an important component of the NK mediated immune response to HIV and/or other infectious pathogens. Crown Copyright (C) 2004 Published by Elsevier Ltd. All rights reserved.

Original language	English
Pages (from-to)	557-560
Journal	Molecular Immunology
Volume	42
DOIs	https://doi.org/10.1016/j.molimm.2004.07.041
Publication status	Published - 2005

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title = "Associations between KIR epitope combinations expressed by HLA-B/-C haplotypes found in an HIV-1 infected study population may influence NK mediated immune responses",

abstract = "The Killer Ig-like receptors (KIRs) on NK cells regulate NK activity via the recognition of specific HLA class I products on the surface of target cells. To investigate the level at which these genetically polymorphic receptors and ligands influence HIV-1 disease progression, we examined the effect of KIR and HLA genotype on HIV outcome. We observed a significant association between particular combinations of KIR epitopes expressed by HLA-B/-C haplotypes and propose that the repertoire of KIR epitopes expressed by HLA-B and HLA-C alleles within the context of particular haplotypes may be an important component of the NK mediated immune response to HIV and/or other infectious pathogens. Crown Copyright (C) 2004 Published by Elsevier Ltd. All rights reserved.",

author = "Silvana Gaudieri and D. Nolan and E. Mckinnon and C.S. Witt and S. Mallal and Frank Christiansen",

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doi = "10.1016/j.molimm.2004.07.041",

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T1 - Associations between KIR epitope combinations expressed by HLA-B/-C haplotypes found in an HIV-1 infected study population may influence NK mediated immune responses

AU - Gaudieri, Silvana

AU - Nolan, D.

AU - Mckinnon, E.

AU - Witt, C.S.

AU - Mallal, S.

AU - Christiansen, Frank

PY - 2005

Y1 - 2005

N2 - The Killer Ig-like receptors (KIRs) on NK cells regulate NK activity via the recognition of specific HLA class I products on the surface of target cells. To investigate the level at which these genetically polymorphic receptors and ligands influence HIV-1 disease progression, we examined the effect of KIR and HLA genotype on HIV outcome. We observed a significant association between particular combinations of KIR epitopes expressed by HLA-B/-C haplotypes and propose that the repertoire of KIR epitopes expressed by HLA-B and HLA-C alleles within the context of particular haplotypes may be an important component of the NK mediated immune response to HIV and/or other infectious pathogens. Crown Copyright (C) 2004 Published by Elsevier Ltd. All rights reserved.

AB - The Killer Ig-like receptors (KIRs) on NK cells regulate NK activity via the recognition of specific HLA class I products on the surface of target cells. To investigate the level at which these genetically polymorphic receptors and ligands influence HIV-1 disease progression, we examined the effect of KIR and HLA genotype on HIV outcome. We observed a significant association between particular combinations of KIR epitopes expressed by HLA-B/-C haplotypes and propose that the repertoire of KIR epitopes expressed by HLA-B and HLA-C alleles within the context of particular haplotypes may be an important component of the NK mediated immune response to HIV and/or other infectious pathogens. Crown Copyright (C) 2004 Published by Elsevier Ltd. All rights reserved.

U2 - 10.1016/j.molimm.2004.07.041

DO - 10.1016/j.molimm.2004.07.041

M3 - Review article

C2 - 15607813

SN - 0161-5890

VL - 42

SP - 557

EP - 560

JO - Molecular Immunology

JF - Molecular Immunology

ER -

Associations between KIR epitope combinations expressed by HLA-B/-C haplotypes found in an HIV-1 infected study population may influence NK mediated immune responses

Abstract

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