Associations between cardiovascular disease, cancer, and very low high-density lipoprotein cholesterol in the REasons for Geographical and Racial Differences in Stroke (REGARDS) study

Peter Penson, D. Leann Long, George Howard, Virginia J. Howard, Steven R. Jones, Seth S. Martin, Dimitri P. Mikhailidis, Paul Muntner, Manfredi Rizzo, Daniel J. Rader, Monika M. Safford, Amirhossein Sahebkar, Peter P. Toth, Maciej Banach

Research output: Contribution to journalArticle

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Abstract

Aims Relatively little is known about the health outcomes associated with very low plasma concentrations of high-density lipoprotein cholesterol (HDL-C) mainly because of the small numbers of individuals with such extreme values included in clinical trials. We, therefore, investigated the association between low and very low HDL-C concentration at baseline and incident all-cause-mortality, death from malignant disease (i.e. cancer), and with fatal or non-fatal incident coronary heart disease (CHD) in individuals from the Reasons for Geographical And Racial Differences in Stroke (REGARDS) study.

Methods and results Analysis was based on 21751 participants from the REGARDS study who were free of CHD, other cardiovascular disease, and cancer at baseline and were categorized by baseline HDL-C into

Conclusion Low HDL-C was associated with reduced risk of incident CHD in black participants suggesting a potential HDL paradox for incident CHD. Very low HDL-C in women was significantly associated with cancer mortality in a fully adjusted complete case model.

Original languageEnglish
Pages (from-to)204-212
Number of pages9
JournalCardiovascular Research
Volume115
Issue number1
DOIs
Publication statusPublished - 1 Jan 2019

Cite this

Penson, Peter ; Long, D. Leann ; Howard, George ; Howard, Virginia J. ; Jones, Steven R. ; Martin, Seth S. ; Mikhailidis, Dimitri P. ; Muntner, Paul ; Rizzo, Manfredi ; Rader, Daniel J. ; Safford, Monika M. ; Sahebkar, Amirhossein ; Toth, Peter P. ; Banach, Maciej. / Associations between cardiovascular disease, cancer, and very low high-density lipoprotein cholesterol in the REasons for Geographical and Racial Differences in Stroke (REGARDS) study. In: Cardiovascular Research. 2019 ; Vol. 115, No. 1. pp. 204-212.
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title = "Associations between cardiovascular disease, cancer, and very low high-density lipoprotein cholesterol in the REasons for Geographical and Racial Differences in Stroke (REGARDS) study",
abstract = "Aims Relatively little is known about the health outcomes associated with very low plasma concentrations of high-density lipoprotein cholesterol (HDL-C) mainly because of the small numbers of individuals with such extreme values included in clinical trials. We, therefore, investigated the association between low and very low HDL-C concentration at baseline and incident all-cause-mortality, death from malignant disease (i.e. cancer), and with fatal or non-fatal incident coronary heart disease (CHD) in individuals from the Reasons for Geographical And Racial Differences in Stroke (REGARDS) study.Methods and results Analysis was based on 21751 participants from the REGARDS study who were free of CHD, other cardiovascular disease, and cancer at baseline and were categorized by baseline HDL-C intoConclusion Low HDL-C was associated with reduced risk of incident CHD in black participants suggesting a potential HDL paradox for incident CHD. Very low HDL-C in women was significantly associated with cancer mortality in a fully adjusted complete case model.",
keywords = "Cholesterol, Coronary heart disease, HDL, Malignant disease, Mortality, CORONARY-HEART-DISEASE, HDL-CHOLESTEROL, SECONDARY PREVENTION, MULTIPLE IMPUTATION, THERAPEUTIC TARGET, STATIN THERAPY, RESIDUAL RISK, WHITE MEN, PATIENT, PROTEIN",
author = "Peter Penson and Long, {D. Leann} and George Howard and Howard, {Virginia J.} and Jones, {Steven R.} and Martin, {Seth S.} and Mikhailidis, {Dimitri P.} and Paul Muntner and Manfredi Rizzo and Rader, {Daniel J.} and Safford, {Monika M.} and Amirhossein Sahebkar and Toth, {Peter P.} and Maciej Banach",
year = "2019",
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doi = "10.1093/cvr/cvy198",
language = "English",
volume = "115",
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Penson, P, Long, DL, Howard, G, Howard, VJ, Jones, SR, Martin, SS, Mikhailidis, DP, Muntner, P, Rizzo, M, Rader, DJ, Safford, MM, Sahebkar, A, Toth, PP & Banach, M 2019, 'Associations between cardiovascular disease, cancer, and very low high-density lipoprotein cholesterol in the REasons for Geographical and Racial Differences in Stroke (REGARDS) study' Cardiovascular Research, vol. 115, no. 1, pp. 204-212. https://doi.org/10.1093/cvr/cvy198

Associations between cardiovascular disease, cancer, and very low high-density lipoprotein cholesterol in the REasons for Geographical and Racial Differences in Stroke (REGARDS) study. / Penson, Peter; Long, D. Leann; Howard, George; Howard, Virginia J.; Jones, Steven R.; Martin, Seth S.; Mikhailidis, Dimitri P.; Muntner, Paul; Rizzo, Manfredi; Rader, Daniel J.; Safford, Monika M.; Sahebkar, Amirhossein; Toth, Peter P.; Banach, Maciej.

In: Cardiovascular Research, Vol. 115, No. 1, 01.01.2019, p. 204-212.

Research output: Contribution to journalArticle

TY - JOUR

T1 - Associations between cardiovascular disease, cancer, and very low high-density lipoprotein cholesterol in the REasons for Geographical and Racial Differences in Stroke (REGARDS) study

AU - Penson, Peter

AU - Long, D. Leann

AU - Howard, George

AU - Howard, Virginia J.

AU - Jones, Steven R.

AU - Martin, Seth S.

AU - Mikhailidis, Dimitri P.

AU - Muntner, Paul

AU - Rizzo, Manfredi

AU - Rader, Daniel J.

AU - Safford, Monika M.

AU - Sahebkar, Amirhossein

AU - Toth, Peter P.

AU - Banach, Maciej

PY - 2019/1/1

Y1 - 2019/1/1

N2 - Aims Relatively little is known about the health outcomes associated with very low plasma concentrations of high-density lipoprotein cholesterol (HDL-C) mainly because of the small numbers of individuals with such extreme values included in clinical trials. We, therefore, investigated the association between low and very low HDL-C concentration at baseline and incident all-cause-mortality, death from malignant disease (i.e. cancer), and with fatal or non-fatal incident coronary heart disease (CHD) in individuals from the Reasons for Geographical And Racial Differences in Stroke (REGARDS) study.Methods and results Analysis was based on 21751 participants from the REGARDS study who were free of CHD, other cardiovascular disease, and cancer at baseline and were categorized by baseline HDL-C intoConclusion Low HDL-C was associated with reduced risk of incident CHD in black participants suggesting a potential HDL paradox for incident CHD. Very low HDL-C in women was significantly associated with cancer mortality in a fully adjusted complete case model.

AB - Aims Relatively little is known about the health outcomes associated with very low plasma concentrations of high-density lipoprotein cholesterol (HDL-C) mainly because of the small numbers of individuals with such extreme values included in clinical trials. We, therefore, investigated the association between low and very low HDL-C concentration at baseline and incident all-cause-mortality, death from malignant disease (i.e. cancer), and with fatal or non-fatal incident coronary heart disease (CHD) in individuals from the Reasons for Geographical And Racial Differences in Stroke (REGARDS) study.Methods and results Analysis was based on 21751 participants from the REGARDS study who were free of CHD, other cardiovascular disease, and cancer at baseline and were categorized by baseline HDL-C intoConclusion Low HDL-C was associated with reduced risk of incident CHD in black participants suggesting a potential HDL paradox for incident CHD. Very low HDL-C in women was significantly associated with cancer mortality in a fully adjusted complete case model.

KW - Cholesterol

KW - Coronary heart disease

KW - HDL

KW - Malignant disease

KW - Mortality

KW - CORONARY-HEART-DISEASE

KW - HDL-CHOLESTEROL

KW - SECONDARY PREVENTION

KW - MULTIPLE IMPUTATION

KW - THERAPEUTIC TARGET

KW - STATIN THERAPY

KW - RESIDUAL RISK

KW - WHITE MEN

KW - PATIENT

KW - PROTEIN

U2 - 10.1093/cvr/cvy198

DO - 10.1093/cvr/cvy198

M3 - Article

VL - 115

SP - 204

EP - 212

JO - Cardiovascular Research

JF - Cardiovascular Research

SN - 0008-6363

IS - 1

ER -