Associations between cardiovascular disease, cancer, and very low high-density lipoprotein cholesterol in the REasons for Geographical and Racial Differences in Stroke (REGARDS) study

Peter Penson, D. Leann Long, George Howard, Virginia J. Howard, Steven R. Jones, Seth S. Martin, Dimitri P. Mikhailidis, Paul Muntner, Manfredi Rizzo, Daniel J. Rader, Monika M. Safford, Amirhossein Sahebkar, Peter P. Toth, Maciej Banach

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Abstract

Aims Relatively little is known about the health outcomes associated with very low plasma concentrations of high-density lipoprotein cholesterol (HDL-C) mainly because of the small numbers of individuals with such extreme values included in clinical trials. We, therefore, investigated the association between low and very low HDL-C concentration at baseline and incident all-cause-mortality, death from malignant disease (i.e. cancer), and with fatal or non-fatal incident coronary heart disease (CHD) in individuals from the Reasons for Geographical And Racial Differences in Stroke (REGARDS) study.

Methods and results Analysis was based on 21751 participants from the REGARDS study who were free of CHD, other cardiovascular disease, and cancer at baseline and were categorized by baseline HDL-C into

Conclusion Low HDL-C was associated with reduced risk of incident CHD in black participants suggesting a potential HDL paradox for incident CHD. Very low HDL-C in women was significantly associated with cancer mortality in a fully adjusted complete case model.

Original languageEnglish
Pages (from-to)204-212
Number of pages9
JournalCardiovascular Research
Volume115
Issue number1
DOIs
Publication statusPublished - 1 Jan 2019

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