Association of vegetable nitrate intake with carotid atherosclerosis and ischemic cerebrovascular disease in older women

Catherine P. Bondonno, Lauren C. Blekkenhorst, Richard L. Prince, Kerry L. Ivey, Joshua R. Lewis, Amanda Devine, Richard J. Woodman, Jon O. Lundberg, Kevin D. Croft, Peter L. Thompson, Jonathan M. Hodgson

Research output: Contribution to journalArticle

20 Citations (Scopus)

Abstract

Background and Purpose - A short-term increase in dietary nitrate (NO 3 -) improves markers of vascular health via formation of nitric oxide and other bioactive nitrogen oxides. Whether this translates into long-term vascular disease risk reduction has yet to be examined. We investigated the association of vegetable-derived nitrate intake with common carotid artery intima-media thickness (CCA-IMT), plaque severity, and ischemic cerebrovascular disease events in elderly women (n=1226). Methods - Vegetable nitrate intake, lifestyle factors, and cardiovascular disease risk factors were determined at baseline (1998). CCA-IMT and plaque severity were measured using B-mode carotid ultrasound (2001). Complete ischemic cerebrovascular disease hospitalizations or deaths (events) over 14.5 years (15 032 person-years of follow-up) were obtained from the West Australian Data Linkage System. Results - Higher vegetable nitrate intake was associated with a lower maximum CCA-IMT (B=-0.015, P=0.002) and lower mean CCA-IMT (B=-0.012, P=0.006). This relationship remained significant after adjustment for lifestyle and cardiovascular risk factors (P≤0.01). Vegetable nitrate intake was not a predictor of plaque severity. In total 186 (15%) women experienced an ischemic cerebrovascular disease event. For every 1 SD (29 mg/d) higher intake of vegetable nitrate, there was an associated 17% lower risk of 14.5-year ischemic cerebrovascular disease events in both unadjusted and fully adjusted models (P=0.02). Conclusions - Independent of other risk factors, higher vegetable nitrate was associated with a lower CCA-IMT and a lower risk of an ischemic cerebrovascular disease event. © 2017 American Heart Association, Inc.

Original languageEnglish
Pages (from-to)1724-1729
Number of pages6
JournalStroke
Volume48
Issue number7
DOIs
Publication statusPublished - 1 Jul 2017

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Cerebrovascular Disorders
Carotid Artery Diseases
Vegetables
Nitrates
Carotid Intima-Media Thickness
Common Carotid Artery
Life Style
Nitrogen Oxides
Information Storage and Retrieval
Risk Reduction Behavior
Vascular Diseases
Information Systems
Blood Vessels
Nitric Oxide
Hospitalization
Cardiovascular Diseases
Health

Cite this

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title = "Association of vegetable nitrate intake with carotid atherosclerosis and ischemic cerebrovascular disease in older women",
abstract = "Background and Purpose - A short-term increase in dietary nitrate (NO 3 -) improves markers of vascular health via formation of nitric oxide and other bioactive nitrogen oxides. Whether this translates into long-term vascular disease risk reduction has yet to be examined. We investigated the association of vegetable-derived nitrate intake with common carotid artery intima-media thickness (CCA-IMT), plaque severity, and ischemic cerebrovascular disease events in elderly women (n=1226). Methods - Vegetable nitrate intake, lifestyle factors, and cardiovascular disease risk factors were determined at baseline (1998). CCA-IMT and plaque severity were measured using B-mode carotid ultrasound (2001). Complete ischemic cerebrovascular disease hospitalizations or deaths (events) over 14.5 years (15 032 person-years of follow-up) were obtained from the West Australian Data Linkage System. Results - Higher vegetable nitrate intake was associated with a lower maximum CCA-IMT (B=-0.015, P=0.002) and lower mean CCA-IMT (B=-0.012, P=0.006). This relationship remained significant after adjustment for lifestyle and cardiovascular risk factors (P≤0.01). Vegetable nitrate intake was not a predictor of plaque severity. In total 186 (15{\%}) women experienced an ischemic cerebrovascular disease event. For every 1 SD (29 mg/d) higher intake of vegetable nitrate, there was an associated 17{\%} lower risk of 14.5-year ischemic cerebrovascular disease events in both unadjusted and fully adjusted models (P=0.02). Conclusions - Independent of other risk factors, higher vegetable nitrate was associated with a lower CCA-IMT and a lower risk of an ischemic cerebrovascular disease event. {\circledC} 2017 American Heart Association, Inc.",
keywords = "atherosclerosis, cardiovascular disease, cerebrovascular disease, nitrates, vegetables",
author = "Bondonno, {Catherine P.} and Blekkenhorst, {Lauren C.} and Prince, {Richard L.} and Ivey, {Kerry L.} and Lewis, {Joshua R.} and Amanda Devine and Woodman, {Richard J.} and Lundberg, {Jon O.} and Croft, {Kevin D.} and Thompson, {Peter L.} and Hodgson, {Jonathan M.}",
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Association of vegetable nitrate intake with carotid atherosclerosis and ischemic cerebrovascular disease in older women. / Bondonno, Catherine P.; Blekkenhorst, Lauren C.; Prince, Richard L.; Ivey, Kerry L.; Lewis, Joshua R.; Devine, Amanda; Woodman, Richard J.; Lundberg, Jon O.; Croft, Kevin D.; Thompson, Peter L.; Hodgson, Jonathan M.

In: Stroke, Vol. 48, No. 7, 01.07.2017, p. 1724-1729.

Research output: Contribution to journalArticle

TY - JOUR

T1 - Association of vegetable nitrate intake with carotid atherosclerosis and ischemic cerebrovascular disease in older women

AU - Bondonno, Catherine P.

AU - Blekkenhorst, Lauren C.

AU - Prince, Richard L.

AU - Ivey, Kerry L.

AU - Lewis, Joshua R.

AU - Devine, Amanda

AU - Woodman, Richard J.

AU - Lundberg, Jon O.

AU - Croft, Kevin D.

AU - Thompson, Peter L.

AU - Hodgson, Jonathan M.

PY - 2017/7/1

Y1 - 2017/7/1

N2 - Background and Purpose - A short-term increase in dietary nitrate (NO 3 -) improves markers of vascular health via formation of nitric oxide and other bioactive nitrogen oxides. Whether this translates into long-term vascular disease risk reduction has yet to be examined. We investigated the association of vegetable-derived nitrate intake with common carotid artery intima-media thickness (CCA-IMT), plaque severity, and ischemic cerebrovascular disease events in elderly women (n=1226). Methods - Vegetable nitrate intake, lifestyle factors, and cardiovascular disease risk factors were determined at baseline (1998). CCA-IMT and plaque severity were measured using B-mode carotid ultrasound (2001). Complete ischemic cerebrovascular disease hospitalizations or deaths (events) over 14.5 years (15 032 person-years of follow-up) were obtained from the West Australian Data Linkage System. Results - Higher vegetable nitrate intake was associated with a lower maximum CCA-IMT (B=-0.015, P=0.002) and lower mean CCA-IMT (B=-0.012, P=0.006). This relationship remained significant after adjustment for lifestyle and cardiovascular risk factors (P≤0.01). Vegetable nitrate intake was not a predictor of plaque severity. In total 186 (15%) women experienced an ischemic cerebrovascular disease event. For every 1 SD (29 mg/d) higher intake of vegetable nitrate, there was an associated 17% lower risk of 14.5-year ischemic cerebrovascular disease events in both unadjusted and fully adjusted models (P=0.02). Conclusions - Independent of other risk factors, higher vegetable nitrate was associated with a lower CCA-IMT and a lower risk of an ischemic cerebrovascular disease event. © 2017 American Heart Association, Inc.

AB - Background and Purpose - A short-term increase in dietary nitrate (NO 3 -) improves markers of vascular health via formation of nitric oxide and other bioactive nitrogen oxides. Whether this translates into long-term vascular disease risk reduction has yet to be examined. We investigated the association of vegetable-derived nitrate intake with common carotid artery intima-media thickness (CCA-IMT), plaque severity, and ischemic cerebrovascular disease events in elderly women (n=1226). Methods - Vegetable nitrate intake, lifestyle factors, and cardiovascular disease risk factors were determined at baseline (1998). CCA-IMT and plaque severity were measured using B-mode carotid ultrasound (2001). Complete ischemic cerebrovascular disease hospitalizations or deaths (events) over 14.5 years (15 032 person-years of follow-up) were obtained from the West Australian Data Linkage System. Results - Higher vegetable nitrate intake was associated with a lower maximum CCA-IMT (B=-0.015, P=0.002) and lower mean CCA-IMT (B=-0.012, P=0.006). This relationship remained significant after adjustment for lifestyle and cardiovascular risk factors (P≤0.01). Vegetable nitrate intake was not a predictor of plaque severity. In total 186 (15%) women experienced an ischemic cerebrovascular disease event. For every 1 SD (29 mg/d) higher intake of vegetable nitrate, there was an associated 17% lower risk of 14.5-year ischemic cerebrovascular disease events in both unadjusted and fully adjusted models (P=0.02). Conclusions - Independent of other risk factors, higher vegetable nitrate was associated with a lower CCA-IMT and a lower risk of an ischemic cerebrovascular disease event. © 2017 American Heart Association, Inc.

KW - atherosclerosis

KW - cardiovascular disease

KW - cerebrovascular disease

KW - nitrates

KW - vegetables

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