Association of TNF-α-857C with Inflammatory Bowel Disease in the Australian Population

N.J. O'Callaghan, Kirsten Adams, D.A. Van Heel, J.A. Cavanaugh

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    33 Citations (Scopus)


    Background: It is now well established that susceptibility to inflammatory bowel disease is in partgenetic, with one localization on chromosome 6 (IBD3) having been replicated in a number ofpopulations. A candidate in that region, TNF-α contains polymorphisms in the promoter region thatappear to be associated with disease. Methods: More than 600 individuals from 170 multiplex IBDfamilies were genotyped for four polymorphisms in the TNF-α gene and analysed for association. Resultsand Conclusion: A strong association was observed between transmission of the -857 C allele anddisease. This effect was strongest in those families in which the NOD2 risk alleles are also segregating,supporting the existence of an interaction between IBD3 and IBD1 on chromosome 16.
    Original languageEnglish
    Pages (from-to)533-534
    JournalScandinavian Journal of Gastroenterology
    Issue number5
    Publication statusPublished - 2003


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