Association of serum pepsinogens and gastrin-17 with Helicobacter pylori infection assessed by urea breath test

Jun-peng Zhou, Chang-hai Liu, Bo-wen Liu, You-juan Wang, Mohammed Benghezal, Barry James Marshall, Hong Tang, Hong Li

Research output: Contribution to journalArticlepeer-review

Abstract

BackgroundAssociation of gastric atrophy or cancer with levels of serum pepsinogens, gastrin-17 and anti-Helicobacter pylori IgG antibody have been extensively studied. However, the association of serum pepsinogen and gastrin-17 with H. pylori infection has not been studied in a large population. AimTo investigate the impact of H. pylori infection on serum levels of pepsinogens and gastrin-17. MethodsA total of 354, 972 subjects who underwent health check-ups were included. Serum levels of pepsinogens and gastrin-17 were measured using the enzyme-linked immunosorbent assay. H. pylori infection was detected using C-14-urea breath test (UBT). Multivariable logistic regression analysis was used to investigate the association of serum pepsinogen and gastrin-17 with H. pylori infection. ResultsH. pylori prevalence was 33.18% in this study. The mean levels of pepsinogens and gastrin-17 were higher, while the mean pepsinogen-I/II ratio were lower among H. pylori-positive than -negative subjects. In H. pylori-positive subjects, pepsinogen and gastrin-17 levels correlated positively, whereas the pepsinogen-I/II ratio correlated negatively with UBT values (e.g., the mean serum level of pepsinogen-I in subjects with UBT values in the range of 100-499dpm, 500-1499dpm, and >= 1500dpm was 94.77 +/- 38.99, 102.77 +/- 43.59, and 111.53 +/- 47.47 ng/mL, respectively). Compared with H. pylori-negative subjects, the adjusted odds ratio (aOR) of having pepsinogen-I 5.70 pmol/L was 4.56 (p5.70 pmol/L (a marker for peptic ulcer). ConclusionsH. pylori-positive subjects with higher UBT values are unlikely to have gastric atrophy, but may have greater risk of severe gastritis or peptic ulcers. Our study suggests that H. pylori-positive patients with high UBT values may benefit the most from H. pylori eradication.

Original languageEnglish
Article number980399
Number of pages11
JournalFrontiers in Cellular and Infection Microbiology
Volume12
DOIs
Publication statusPublished - 16 Aug 2022

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