Association of serum gamma-glutamyltransferase and C-reactive proteins with neuromyelitis optica and multiple sclerosis

Yaqing Shu, Rui Li, Wei Qiu, Yanyu Chang, Xiaobo Sun, Ling Fang, Chen Chen, Yu Yang, Zhengqi Lu, Xueqiang Hu, Allan G. Kermode

    Research output: Contribution to journalArticle

    2 Citations (Scopus)

    Abstract

    Background Many studies have demonstrated that serum gamma glutamyltransferase (GGT) within normal range might be an early marker of oxidative stress. However the role of GGT in neuromyelitis optica (NMO) and multiple sclerosis (MS) is unknown. Methods We assessed the correlations among GGT and C-reactive protein (CRP) levels, as well as clinical characteristics of NMO and MS. Serum GGT and CRP levels were measured in 106 NMO patients, 87 MS patients, 79 patients with non-inflammatory neurological diseases (Parkinson disease) and 80 healthy controls (HC). Clinical parameters, blood-brain barrier (BBB) index and Delpech index of MS and NMO were also investigated. Results We found that NMO patients had higher serum GGT and CRP levels within their normal ranges compared to MS, PD, healthy controls. NMO patients exhibited significantly higher EDSS scores than MS patients. The BBB index in NMO patients was significantly higher than that in MS patients. Significant correlations existed between serum GGT and CRP levels and EDSS scores, BBB index in NMO and MS patients. Conclusion Elevated GGT and CRP levels within their normal ranges in NMO and MS may be associated with inflammatory response, oxidative stress and BBB disturbance in the diseases. Further study into the underlying pathophysiology of this relationship is warranted.

    Original languageEnglish
    Pages (from-to)65-70
    Number of pages6
    JournalMultiple Sclerosis and Related Disorders
    Volume18
    DOIs
    Publication statusPublished - 1 Nov 2017

    Fingerprint

    Neuromyelitis Optica
    gamma-Glutamyltransferase
    C-Reactive Protein
    Multiple Sclerosis
    Serum
    Blood-Brain Barrier
    Reference Values
    Oxidative Stress
    Parkinson Disease

    Cite this

    Shu, Yaqing ; Li, Rui ; Qiu, Wei ; Chang, Yanyu ; Sun, Xiaobo ; Fang, Ling ; Chen, Chen ; Yang, Yu ; Lu, Zhengqi ; Hu, Xueqiang ; Kermode, Allan G. / Association of serum gamma-glutamyltransferase and C-reactive proteins with neuromyelitis optica and multiple sclerosis. In: Multiple Sclerosis and Related Disorders. 2017 ; Vol. 18. pp. 65-70.
    @article{3314d30c0e854096ac77857a77c0f487,
    title = "Association of serum gamma-glutamyltransferase and C-reactive proteins with neuromyelitis optica and multiple sclerosis",
    abstract = "Background Many studies have demonstrated that serum gamma glutamyltransferase (GGT) within normal range might be an early marker of oxidative stress. However the role of GGT in neuromyelitis optica (NMO) and multiple sclerosis (MS) is unknown. Methods We assessed the correlations among GGT and C-reactive protein (CRP) levels, as well as clinical characteristics of NMO and MS. Serum GGT and CRP levels were measured in 106 NMO patients, 87 MS patients, 79 patients with non-inflammatory neurological diseases (Parkinson disease) and 80 healthy controls (HC). Clinical parameters, blood-brain barrier (BBB) index and Delpech index of MS and NMO were also investigated. Results We found that NMO patients had higher serum GGT and CRP levels within their normal ranges compared to MS, PD, healthy controls. NMO patients exhibited significantly higher EDSS scores than MS patients. The BBB index in NMO patients was significantly higher than that in MS patients. Significant correlations existed between serum GGT and CRP levels and EDSS scores, BBB index in NMO and MS patients. Conclusion Elevated GGT and CRP levels within their normal ranges in NMO and MS may be associated with inflammatory response, oxidative stress and BBB disturbance in the diseases. Further study into the underlying pathophysiology of this relationship is warranted.",
    keywords = "Blood-brain barrier, C-reactive protein, neuromyelitis optica, Gamma-glutamyltransferase, Multiple sclerosis, Oxidative stress",
    author = "Yaqing Shu and Rui Li and Wei Qiu and Yanyu Chang and Xiaobo Sun and Ling Fang and Chen Chen and Yu Yang and Zhengqi Lu and Xueqiang Hu and Kermode, {Allan G.}",
    year = "2017",
    month = "11",
    day = "1",
    doi = "10.1016/j.msard.2017.09.021",
    language = "English",
    volume = "18",
    pages = "65--70",
    journal = "Multiple Sclerosis and Related Disorders",
    issn = "2211-0348",
    publisher = "Elsevier",

    }

    Association of serum gamma-glutamyltransferase and C-reactive proteins with neuromyelitis optica and multiple sclerosis. / Shu, Yaqing; Li, Rui; Qiu, Wei; Chang, Yanyu; Sun, Xiaobo; Fang, Ling; Chen, Chen; Yang, Yu; Lu, Zhengqi; Hu, Xueqiang; Kermode, Allan G.

    In: Multiple Sclerosis and Related Disorders, Vol. 18, 01.11.2017, p. 65-70.

    Research output: Contribution to journalArticle

    TY - JOUR

    T1 - Association of serum gamma-glutamyltransferase and C-reactive proteins with neuromyelitis optica and multiple sclerosis

    AU - Shu, Yaqing

    AU - Li, Rui

    AU - Qiu, Wei

    AU - Chang, Yanyu

    AU - Sun, Xiaobo

    AU - Fang, Ling

    AU - Chen, Chen

    AU - Yang, Yu

    AU - Lu, Zhengqi

    AU - Hu, Xueqiang

    AU - Kermode, Allan G.

    PY - 2017/11/1

    Y1 - 2017/11/1

    N2 - Background Many studies have demonstrated that serum gamma glutamyltransferase (GGT) within normal range might be an early marker of oxidative stress. However the role of GGT in neuromyelitis optica (NMO) and multiple sclerosis (MS) is unknown. Methods We assessed the correlations among GGT and C-reactive protein (CRP) levels, as well as clinical characteristics of NMO and MS. Serum GGT and CRP levels were measured in 106 NMO patients, 87 MS patients, 79 patients with non-inflammatory neurological diseases (Parkinson disease) and 80 healthy controls (HC). Clinical parameters, blood-brain barrier (BBB) index and Delpech index of MS and NMO were also investigated. Results We found that NMO patients had higher serum GGT and CRP levels within their normal ranges compared to MS, PD, healthy controls. NMO patients exhibited significantly higher EDSS scores than MS patients. The BBB index in NMO patients was significantly higher than that in MS patients. Significant correlations existed between serum GGT and CRP levels and EDSS scores, BBB index in NMO and MS patients. Conclusion Elevated GGT and CRP levels within their normal ranges in NMO and MS may be associated with inflammatory response, oxidative stress and BBB disturbance in the diseases. Further study into the underlying pathophysiology of this relationship is warranted.

    AB - Background Many studies have demonstrated that serum gamma glutamyltransferase (GGT) within normal range might be an early marker of oxidative stress. However the role of GGT in neuromyelitis optica (NMO) and multiple sclerosis (MS) is unknown. Methods We assessed the correlations among GGT and C-reactive protein (CRP) levels, as well as clinical characteristics of NMO and MS. Serum GGT and CRP levels were measured in 106 NMO patients, 87 MS patients, 79 patients with non-inflammatory neurological diseases (Parkinson disease) and 80 healthy controls (HC). Clinical parameters, blood-brain barrier (BBB) index and Delpech index of MS and NMO were also investigated. Results We found that NMO patients had higher serum GGT and CRP levels within their normal ranges compared to MS, PD, healthy controls. NMO patients exhibited significantly higher EDSS scores than MS patients. The BBB index in NMO patients was significantly higher than that in MS patients. Significant correlations existed between serum GGT and CRP levels and EDSS scores, BBB index in NMO and MS patients. Conclusion Elevated GGT and CRP levels within their normal ranges in NMO and MS may be associated with inflammatory response, oxidative stress and BBB disturbance in the diseases. Further study into the underlying pathophysiology of this relationship is warranted.

    KW - Blood-brain barrier

    KW - C-reactive protein, neuromyelitis optica

    KW - Gamma-glutamyltransferase

    KW - Multiple sclerosis

    KW - Oxidative stress

    UR - http://www.scopus.com/inward/record.url?scp=85029885400&partnerID=8YFLogxK

    U2 - 10.1016/j.msard.2017.09.021

    DO - 10.1016/j.msard.2017.09.021

    M3 - Article

    VL - 18

    SP - 65

    EP - 70

    JO - Multiple Sclerosis and Related Disorders

    JF - Multiple Sclerosis and Related Disorders

    SN - 2211-0348

    ER -