Association of obstructive sleep apnoea and long-term cardiovascular events in a prospective sleep clinic cohort

Bindiya Shenoy

doi:10.26182/st6q-ks08

Association of obstructive sleep apnoea and long-term cardiovascular events in a prospective sleep clinic cohort

Bindiya Shenoy

School of Human Sciences

Research output: Thesis › Doctoral Thesis

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Abstract

Obstructive sleep apnoea (OSA), a complex heterogenous sleep disorder, is an independent risk factor for major adverse cardiovascular events (MACE); however, the magnitude of this relationship is not fully understood. This thesis studied a large well-characterised sleep clinic cohort, the West Australian Sleep Health Study, and sought to examine the relationship between OSA, cardiovascular risk factors, and adherent long-term continuous positive airway pressure therapy to identify OSA phenotypes at increased risk of MACE. The findings of this thesis may help facilitate a precision medicine approach in OSA and provide important targets for clinical trials of OSA treatment.

Original language	English
Qualification	Doctor of Philosophy
Awarding Institution	The University of Western Australia
Supervisors/Advisors	Walsh, Jen, Supervisor McQuillan, Brendan, Supervisor Cadby, Gemma, Supervisor Singh, Bhajan, Supervisor McArdle, Nigel, Supervisor Eastwood, Peter, Supervisor, External person
Thesis sponsors	Australian Government Research Training Program
Award date	30 May 2024
DOIs	https://doi.org/10.26182/st6q-ks08
Publication status	Unpublished - 2023

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10.26182/st6q-ks08

THESIS - DOCTOR OF PHILOSOPHY - SHENOY Bindiya - 2023
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1 Article

Cohort profile: the Western Australian Sleep Health Study
Mukherjee, S., Hillman, D., Lee, J., Fedson, A., Simpson, L., Ward, K., Love, G., Edwards, C., Szegner, B. & Palmer, L., 2012, In: SLEEP AND BREATHING. 16, 1, p. 205-215
Research output: Contribution to journal › Article › peer-review
15 Citations (Scopus)

Cite this

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title = "Association of obstructive sleep apnoea and long-term cardiovascular events in a prospective sleep clinic cohort",

abstract = "Obstructive sleep apnoea (OSA), a complex heterogenous sleep disorder, is an independent risk factor for major adverse cardiovascular events (MACE); however, the magnitude of this relationship is not fully understood. This thesis studied a large well-characterised sleep clinic cohort, the West Australian Sleep Health Study, and sought to examine the relationship between OSA, cardiovascular risk factors, and adherent long-term continuous positive airway pressure therapy to identify OSA phenotypes at increased risk of MACE. The findings of this thesis may help facilitate a precision medicine approach in OSA and provide important targets for clinical trials of OSA treatment. ",

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school = "The University of Western Australia",

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AB - Obstructive sleep apnoea (OSA), a complex heterogenous sleep disorder, is an independent risk factor for major adverse cardiovascular events (MACE); however, the magnitude of this relationship is not fully understood. This thesis studied a large well-characterised sleep clinic cohort, the West Australian Sleep Health Study, and sought to examine the relationship between OSA, cardiovascular risk factors, and adherent long-term continuous positive airway pressure therapy to identify OSA phenotypes at increased risk of MACE. The findings of this thesis may help facilitate a precision medicine approach in OSA and provide important targets for clinical trials of OSA treatment.

KW - sleep

KW - sleep disorders

KW - obstructive sleep apnoea

KW - cardiovascular disease

U2 - 10.26182/st6q-ks08

DO - 10.26182/st6q-ks08

M3 - Doctoral Thesis

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Association of obstructive sleep apnoea and long-term cardiovascular events in a prospective sleep clinic cohort

Abstract

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Research output

Cohort profile: the Western Australian Sleep Health Study

Cite this