Association of nitric oxide with oral lichen planus

Abdul Wahab H Alamir, Gururaj Arakeri, Shankargouda Patil, Kamran Habib Awan, Omar Kujan, Abdulsalam Aljabab, Felipe Fonseca, Peter A. Brennan

Research output: Contribution to journalReview article

Abstract


Background

The small signalling molecule nitric oxide (NO) has been postulated to have a mediator role in the pathogenesis of several diseases including oral lichen planus (OLP). This systematic review aimed to quantify the existing literature and assess the association of NO and OLP.


Methods

The focused question being addressed was “Is there an association between nitric oxide and OLP?” PubMed, EMBASE, Scopus, and Web of Science, and grey literature from January 1990 to August 2018 were searched. Two independent reviewers performed the study selection using specified eligibility criteria.


Results

Seven studies that met the eligibility criteria were included. All of these were case‐control studies and 151 patients with OLP were evaluated (mostly females), with an age ranged from 20 to 75 years. The included studies showed a significant higher NO levels in OLP patients compared to the healthy controls, with two studies demonstrated a higher NO levels in erosive OLP compared to non‐erosive OLP .


Conclusion

These findings support that an association exists between higher NO concentration and OLP. However, larger high‐quality studies with refined methodological design are needed to confirm the role of NO in the aetiology and pathogenesis of OLP.
Original languageEnglish
Pages (from-to)345-350
Number of pages6
JournalJournal of Oral Pathology & Medicine
Volume48
Issue number5
DOIs
Publication statusPublished - 1 May 2019

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Oral Lichen Planus
Nitric Oxide
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Alamir, A. W. H., Arakeri, G., Patil, S., Awan, K. H., Kujan, O., Aljabab, A., ... Brennan, P. A. (2019). Association of nitric oxide with oral lichen planus. Journal of Oral Pathology & Medicine, 48(5), 345-350. https://doi.org/10.1111/jop.12837
Alamir, Abdul Wahab H ; Arakeri, Gururaj ; Patil, Shankargouda ; Awan, Kamran Habib ; Kujan, Omar ; Aljabab, Abdulsalam ; Fonseca, Felipe ; Brennan, Peter A. / Association of nitric oxide with oral lichen planus. In: Journal of Oral Pathology & Medicine. 2019 ; Vol. 48, No. 5. pp. 345-350.
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Alamir, AWH, Arakeri, G, Patil, S, Awan, KH, Kujan, O, Aljabab, A, Fonseca, F & Brennan, PA 2019, 'Association of nitric oxide with oral lichen planus' Journal of Oral Pathology & Medicine, vol. 48, no. 5, pp. 345-350. https://doi.org/10.1111/jop.12837

Association of nitric oxide with oral lichen planus. / Alamir, Abdul Wahab H ; Arakeri, Gururaj ; Patil, Shankargouda ; Awan, Kamran Habib ; Kujan, Omar; Aljabab, Abdulsalam ; Fonseca, Felipe ; Brennan, Peter A.

In: Journal of Oral Pathology & Medicine, Vol. 48, No. 5, 01.05.2019, p. 345-350.

Research output: Contribution to journalReview article

TY - JOUR

T1 - Association of nitric oxide with oral lichen planus

AU - Alamir, Abdul Wahab H

AU - Arakeri, Gururaj

AU - Patil, Shankargouda

AU - Awan, Kamran Habib

AU - Kujan, Omar

AU - Aljabab, Abdulsalam

AU - Fonseca, Felipe

AU - Brennan, Peter A.

PY - 2019/5/1

Y1 - 2019/5/1

N2 - BackgroundThe small signalling molecule nitric oxide (NO) has been postulated to have a mediator role in the pathogenesis of several diseases including oral lichen planus (OLP). This systematic review aimed to quantify the existing literature and assess the association of NO and OLP.MethodsThe focused question being addressed was “Is there an association between nitric oxide and OLP?” PubMed, EMBASE, Scopus, and Web of Science, and grey literature from January 1990 to August 2018 were searched. Two independent reviewers performed the study selection using specified eligibility criteria. ResultsSeven studies that met the eligibility criteria were included. All of these were case‐control studies and 151 patients with OLP were evaluated (mostly females), with an age ranged from 20 to 75 years. The included studies showed a significant higher NO levels in OLP patients compared to the healthy controls, with two studies demonstrated a higher NO levels in erosive OLP compared to non‐erosive OLP .ConclusionThese findings support that an association exists between higher NO concentration and OLP. However, larger high‐quality studies with refined methodological design are needed to confirm the role of NO in the aetiology and pathogenesis of OLP.

AB - BackgroundThe small signalling molecule nitric oxide (NO) has been postulated to have a mediator role in the pathogenesis of several diseases including oral lichen planus (OLP). This systematic review aimed to quantify the existing literature and assess the association of NO and OLP.MethodsThe focused question being addressed was “Is there an association between nitric oxide and OLP?” PubMed, EMBASE, Scopus, and Web of Science, and grey literature from January 1990 to August 2018 were searched. Two independent reviewers performed the study selection using specified eligibility criteria. ResultsSeven studies that met the eligibility criteria were included. All of these were case‐control studies and 151 patients with OLP were evaluated (mostly females), with an age ranged from 20 to 75 years. The included studies showed a significant higher NO levels in OLP patients compared to the healthy controls, with two studies demonstrated a higher NO levels in erosive OLP compared to non‐erosive OLP .ConclusionThese findings support that an association exists between higher NO concentration and OLP. However, larger high‐quality studies with refined methodological design are needed to confirm the role of NO in the aetiology and pathogenesis of OLP.

U2 - 10.1111/jop.12837

DO - 10.1111/jop.12837

M3 - Review article

VL - 48

SP - 345

EP - 350

JO - Journal of Oral Pathology & Medicine

JF - Journal of Oral Pathology & Medicine

SN - 0904-2512

IS - 5

ER -

Alamir AWH, Arakeri G, Patil S, Awan KH, Kujan O, Aljabab A et al. Association of nitric oxide with oral lichen planus. Journal of Oral Pathology & Medicine. 2019 May 1;48(5):345-350. https://doi.org/10.1111/jop.12837