Association between slow and delayed graft function with graft outcomes in paediatric and adolescent deceased donor kidney transplant recipients

Wai H.H. Lim, Stephen P.P. McDonald, Sean E.E. Kennedy, Nicholas Larkins, Germaine Wong

    Research output: Contribution to journalArticle

    4 Citations (Scopus)

    Abstract

    BACKGROUND AND OBJECTIVE: Delayed graft function (DGF) is associated with an increased risk of graft loss in adult kidney transplant recipients but the association remains inconsistent in pediatric recipients. The aim of this study is to examine the association between DGF and graft loss in pediatric and adolescent deceased donor kidney transplant recipients aged ≤21 years using Australia and New Zealand Dialysis and Transplant (ANZDATA) registry. METHODS: The associations between DGF status, overall and death-censored graft loss (DCGL) were examined using adjusted Cox regression analyses. RESULTS: There were 367 recipients followed for a median of 9.7 years between 1990 and 2012, with 82 (22%) experiencing DGF requiring dialysis (DGF-D) in the first 72-hours after transplant. Compared to recipients who did not experienced DGF-D, the adjusted hazard ratios for overall graft loss and DCGL in recipients who have experienced DGF-D was 2.08 (95%CI 1.39, 3.11, p

    Original languageEnglish
    Pages (from-to)1906-1912
    JournalTransplantation
    Volume101
    Issue number8
    DOIs
    Publication statusPublished - Aug 2017

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    Delayed Graft Function
    Tissue Donors
    Pediatrics
    Transplants
    Kidney
    Dialysis
    Transplant Recipients
    New Zealand
    Registries
    Regression Analysis

    Cite this

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    title = "Association between slow and delayed graft function with graft outcomes in paediatric and adolescent deceased donor kidney transplant recipients",
    abstract = "BACKGROUND AND OBJECTIVE: Delayed graft function (DGF) is associated with an increased risk of graft loss in adult kidney transplant recipients but the association remains inconsistent in pediatric recipients. The aim of this study is to examine the association between DGF and graft loss in pediatric and adolescent deceased donor kidney transplant recipients aged ≤21 years using Australia and New Zealand Dialysis and Transplant (ANZDATA) registry. METHODS: The associations between DGF status, overall and death-censored graft loss (DCGL) were examined using adjusted Cox regression analyses. RESULTS: There were 367 recipients followed for a median of 9.7 years between 1990 and 2012, with 82 (22{\%}) experiencing DGF requiring dialysis (DGF-D) in the first 72-hours after transplant. Compared to recipients who did not experienced DGF-D, the adjusted hazard ratios for overall graft loss and DCGL in recipients who have experienced DGF-D was 2.08 (95{\%}CI 1.39, 3.11, p",
    author = "Lim, {Wai H.H.} and McDonald, {Stephen P.P.} and Kennedy, {Sean E.E.} and Nicholas Larkins and Germaine Wong",
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    language = "English",
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    Association between slow and delayed graft function with graft outcomes in paediatric and adolescent deceased donor kidney transplant recipients. / Lim, Wai H.H.; McDonald, Stephen P.P.; Kennedy, Sean E.E.; Larkins, Nicholas; Wong, Germaine.

    In: Transplantation, Vol. 101, No. 8, 08.2017, p. 1906-1912.

    Research output: Contribution to journalArticle

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    T1 - Association between slow and delayed graft function with graft outcomes in paediatric and adolescent deceased donor kidney transplant recipients

    AU - Lim, Wai H.H.

    AU - McDonald, Stephen P.P.

    AU - Kennedy, Sean E.E.

    AU - Larkins, Nicholas

    AU - Wong, Germaine

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    AB - BACKGROUND AND OBJECTIVE: Delayed graft function (DGF) is associated with an increased risk of graft loss in adult kidney transplant recipients but the association remains inconsistent in pediatric recipients. The aim of this study is to examine the association between DGF and graft loss in pediatric and adolescent deceased donor kidney transplant recipients aged ≤21 years using Australia and New Zealand Dialysis and Transplant (ANZDATA) registry. METHODS: The associations between DGF status, overall and death-censored graft loss (DCGL) were examined using adjusted Cox regression analyses. RESULTS: There were 367 recipients followed for a median of 9.7 years between 1990 and 2012, with 82 (22%) experiencing DGF requiring dialysis (DGF-D) in the first 72-hours after transplant. Compared to recipients who did not experienced DGF-D, the adjusted hazard ratios for overall graft loss and DCGL in recipients who have experienced DGF-D was 2.08 (95%CI 1.39, 3.11, p

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